scholarly journals Faktor yang Berhubungan dengan Deformitas Kaki pada Penyandang Diabetes Melitus Tipe 2

2021 ◽  
Vol 4 (2) ◽  
pp. 654-662
Author(s):  
Desi Susanti ◽  
Dita Amita
Keyword(s):  
Diabetes Mellitus ◽  
Analytic Method ◽  
Foot Deformity ◽  
Cross Sectional ◽  
Factors Associated ◽  
Type 2 Dm ◽  
Cross Sectional Design ◽  
And Gender ◽  
Diabetes Melitus

This study aims to explain the factors associated with foot deformity in people with type 2 diabetes. This study used a descriptive-analytic method with a cross-sectional design. The results showed that the aspects related to the incidence of foot deformity were education (P=0.022; OR=4.57), body mass index (BMI) (P=0.035; OR=0.23), and knowledge (P=0.001). ; OR = 9.17), while the factors of age (P = 0.22) and gender (P = 0.712) were not associated with the incidence of foot deformity. In conclusion, the knowledge factor is a factor that can influence nine times more strongly the incidence of foot deformity in people with type 2 DM compared to other factors.   Keywords: Foot Deformity, Diabetes Mellitus

Hubungan Kadar Gula Darah Sewaktu (GDS) Dengan Kadar Kreatinin Serum Terhadap Penderita Diabetes Melitus Tipe 2 Di RSUD Dr. H. Bob Bazar, SKM Lampung Selatan

2021 ◽  
Vol 1 (4) ◽  
pp. 471-482
Author(s):  
Zulfian Zulfian ◽  
Muslim Daud Tarmizi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Creatinine ◽  
Blood Sugar ◽  
P Value ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Sugar Levels ◽  
Diabetes Melitus

ABSTRACT: CORRELATION BETWEEN TIME BLOOD SUGAR LEVELS (GDS) WITH SERUM CREATININE LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS AT DR.H. BOB BAZAR, SKM  HOSPITAL LAMPUNG SELATAN Background of study: Diabetes mellitus is a disease condition characterized by increased blood glucose levels or hyperglycemia and a disturbance in the body's metabolism. Based on Rikesdas data, the number of sufferers shows a very significant increase in the prevalence of diabetes, from 6.9% in 2013 to 8.5% in 2018. With this data, Indonesia is the 6th rank DM sufferer in the world. In this diabetic patient, if it is not handled seriously it will trigger complications such as weakening of the kidney function which can be seen from the examination of serum creatinine levels and this is a sign of the onset of complications from diabetes.Purpose: To be able to find out the relationship between current blood sugar levels (GDS) and serum creatinine levels in type 2 diabetes mellitus sufferers at Dr.H Bob Bazar Hospital, SKM South Lampung in 2020. Research Method: This type of research is correlative analytic with cross-sectional using method purposive sampling and random sampling of 201 samples of type 2 DM patients who met the inclusion criteria. Data collection began in December 2020. The data used were secondary data in the form of medical records. Data were evaluated with the test Spearman. Research Results: In this study, Obtained research sample amounted to 201 sufferers of type 2 diabetes with The mean time blood sugar level (GDS) was 227.08 in the standard deviation assessment was 69.84 with the lowest GDS level was 120 and the highest was 392. and The mean serum creatinine level of type 2 DM patients from 201 respondents was 1.42 in the standard deviation assessment was 0.43 with the lowest serum creatinine level was 0.60 and the highest was 2.45. The results of the correlation Spearman showed that the value of p =0.000 and the value of r= + 0.416, because the value of p= 0.000 <0.05 so that it can be stated that Ha is accepted and Ho is declared rejected or there is a significant correlation, with r =0.416 it means that the strength of the correlation is moderate positive between sugar levels blood flow (GDS) with serum creatinine levels in patients with type 2 diabetes. Conclusion: This study concludes there is a significant correlation between blood sugar levels (GDS) and serum creatinine levels in type 2 DM patients with a p-value = 0.000. Keywords: Diabetes Mellitus, Current Blood Sugar (GDS), Serum CreatinineINTISARI: HUBUNGAN KADAR GULA DARAH SEWAKTU (GDS) DENGAN KADAR KREATININ SERUM TERHADAP PENDERITA DIABETES MELITUS TIPE 2 DI RSUD DR.H.BOB BAZAR, SKM LAMPUNG SELATAN Latar Belakang: Diabetes melitus ialah kondisi penyakit yang ditandai dengan meningkatnya kadar glukosa darah atau hiperglikemia serta adanya gangguan dalam metabolisme tubuh. Berdasarkan data Rikesdas jumlah penderita menunjukkan adanya peningkatan angka prevalensi diabetes yang amat signifikan, yakni dari 6,9% pada tahun 2013 menjadi 8,5% pada tahun 2018. Dengan data tersebut peringkat ke-6 penderita DM di dunia diduduki oleh Indonesia. Pada penderita diabetes ini, andaikan tidak ditangani secara serius maka akan mencetuskan komplikasi seperti melemahnya fungsi ginjal dapat dilihat dari pemeriksaan kadar kreatinin serum dan menjadi tanda timbulnya penyakit komplikasi dari diabetes.Tujuan: Untuk dapat mengetahui Hubungan Kadar Gula Darah Sewaktu (GDS) dengan Kadar Kreatinin Serum terhadap penderita diabetes melitus tipe 2 di RSUD Dr.H Bob Bazar, SKM Lampung Selatan tahun 2020. Metode Penelitian: Jenis Penelitian ini adalah analitik korelatif dengan metode cross sectional menggunakan purposive sampling dan random sampling sebanyak 201 sampel pasien DM tipe 2 yang memenuhi kriteria inkulsi. Pengambilan data dimulai pada bulan Desember 2020. Data yang digunakan yaitu data sekunder berupa rekam medik. Data dievaluasi dengan uji Spearman. Hasil Penelitian: Didapatkan sampel penelitian berjumlah 201 penderita DM tipe 2 dengan rata-rata kadar gula darah sewaktu (GDS) didapatkan sebesar 227.08 dalam penilaian standar deviasinya ialah 69.84 dengan kadar gula darah sewaktu (GDS) terendahnya ialah 120 dan yang tertingginya ialah 392. dan rata-rata kadar kreatinin serum penderita DM tipe 2 dari 201 responden didapatkan sebesar 1.42  dalam penilaian standar deviasinya ialah 0.43 dengan kadar kreatinin serum terendahnya ialah 0.60 dan yang tertingginya ialah 2.45. Hasil korelasi Spearman  didapatkan nilai p=0.000 dan nilai r=+0.416, karena nilai p=0.000 <0.05 sehingga dapat dinyatakan Ha diterima dan Ho dinyatakan ditolak atau terdapat korelasi yang bermakna, dengan r=0.416 dapat diartikan kekuatan korelasi sedang positif antara kadar gula darah sewaktu (GDS) dengan kadar kreatinin serum terhadap pasien DM tipe 2.Kesimpulan: Terdapat  korelasi yang bermakna antara kadar gula darah sewaktu (GDS) dengan kadar kreatinin serum terhadap pasien DM tipe 2 dengan p-value= 0.000. Kata Kunci: Diabetes Melitus, Gula Darah Sewaktu (GDS), Kreatinin Serum

scholarly journals Diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Randa I. Farah ◽  
Mohammed Q. Al-Sabbagh ◽  
Munther S. Momani ◽  
Asma Albtoosh ◽  
Majd Arabiat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Laboratory Data ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney ◽  
Type 2 Dm

Abstract Aim Diabetic kidney disease (DKD) is a major long-term complication of diabetes mellitus (DM). Given the paucity of data on DKD in Jordan, we aimed to evaluate the prevalence, characteristics and correlates of DKD in Jordanian patients with type 2 DM. Methods This cross-sectional study included 1398 adult patients with type 2 DM who sought medical advice in the endocrinology clinic between March and September 2019. Demographic, clinical and laboratory data were reviewed. DKD was defined as reduced eGFR, and/or albuminuria. Three regression models were constructed to identify factors associated with CKD stages, albuminuria and DKD. Results Overall, 701 (50.14%) patients had DKD, with a median age of 59.71 ± 11.36  years. Older age, high triglycerides, and low high-density lipoprotein were associated with DKD (multivariable odds ratio [OR]: 1.02, 95% confidence interval [CI]: 1.01–1.03, p < 0.01; OR: 1.1, 95% CI: 1.01–1.2; and OR: 0.98, 95% CI: 0.97–0.99, p < 0.01 respectively). Metformin and renin-angiotensin system blockers were negatively associated with albuminuria and chronic kidney disease stages (p < 0.01). Conclusion Our study demonstrated that approximately one half of patients with type 2 DM had DKD. Further studies are necessary to understand this high prevalence and the underlying factors. Future research are needed to assess implementing targeted community-based intervention.

scholarly journals Factors Associated with Poor Glycemic and Lipid Levels in Ambulatory Diabetes Mellitus Type 2 Patients in Asmara, Eritrea: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Oliver Okoth Achila ◽  
Millen Ghebretinsae ◽  
Abraham Kidane ◽  
Michael Simon ◽  
Shewit Makonen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Waist Circumference ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Specific Lipid

Objective. There is a dearth of relevant research on the rapidly evolving epidemic of diabetes mellitus (particularly Type 2 diabetes mellitus) in sub-Saharan Africa. To address some of these issues in the Eritrean context, we conducted a cross-sectional study on glycemic and lipid profiles and associated risk factors. Methods. A total of 309 patients with diabetes mellitus on regular follow-up at the Diabetic and Hypertensive Department at Halibet Regional Referral Hospital, Asmara, were enrolled for the study. Data on specific clinical chemistry and anthropomorphic parameters was collected. Chi-squared (χ2) test or Fischer’s exact test was used to evaluate the relationship between specific variables. Multivariate logistic regression (backward: conditional) was undertaken to identify the factors associated with increased odds of suboptimal values in glucose and specific lipid panel subfractions. Results. High proportions of patients (76.7%) had suboptimal levels of HbA1c with a mean±SD of 8.6%±1.36, respectively. In multivariate regression analysis, the likelihood of HbA1c≥7% was higher in patients with abnormal WHR (AOR=3.01, 95% CI, 3.01 (1.15–7.92=0.024)) and in patients without hypertension (AOR=1.97, 95% CI (1.06–3.56), p=0.021). A unit reduction in eGFR was also associated with HbA1c≥7% (AOR=0.99, 95% CI (0.98–1=0.031)). In a separate analysis, the data shows that 80.9% of the patients had dyslipidemia. In particular, 62.1% of the patients had TC≥200 mg/dL (risk factors: sex, hypertension, and HbA1c concentration), 81.6% had LDL‐C≥100 mg/dL (risk factors: sex and hypertension), 56.3% had TG≥150 (risk factors: sex, HbA1c, and waist circumference), 62.8% had abnormal HDL-C (risk factors: waist circumference), 78.3% had non‐HDL<130 mg/dL (risk factors: duration of disease, reduced estimated glomerular filtration rate, and HbA1c), and 45.3% had abnormal TG/HDL (risk factors: sex, age of patient, FPG, and waist circumference). Conclusions. The quality of care, as measured by glycemic and specific lipid targets, in this setting is suboptimal. Therefore, there is an urgent need for simultaneous improvements in both indicators. This will require evidence-based optimization of pharmacological and lifestyle interventions. Therefore, additional studies, preferably longitudinal studies with long follow-up, are required on multiple aspects of DM.

scholarly journals HUBUNGAN KUALITAS TIDUR DENGAN KADAR GLUKOSA DARAH PUASA PADA PASIEN DIABETES MELLITUS TIPE II DI PUSKESMAS KASSI-KASSI KOTA MAKASSAR

2020 ◽  
Vol 15 (1) ◽  
pp. 46-50
Author(s):  
Muhammad Basri ◽  
Baharuddin K ◽  
Sitti Rahmatia
Keyword(s):  
Diabetes Mellitus ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Dm Type 2 ◽  
Diabetes Melitus

Diabetes Melitus (DM) merupakan salah satu kelompok penyakit metabolik dan kronis dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau keduaduanya yang membutuhkan perawatan medis dan pendidikan pengelolaan mandiri untuk mencegah komplikasi akut jangka panjang (Nian, 2017). Tujuan penelitian ini adalah Mendeskripsikan hubungan kualitas tidur dengan kadar glukosa darah Puasa pada pasien DM tipe II di PKM Kassi-Kassikota Makassar. Manfaat : Meningkatkan pengetahuan pada Penderita DM Tipe II yang mengalami gangguan Kwalitas dan Pola Tidur shari-hari Meningkatkan pengetahuan pada Penderita DM Tipe II yang mengalami gangguan Kwalitas dan Pola Tidur shari-hari Metode : Pada penelitian ini menggunakan desain cross sectional, jenis penelitian ini menggunakan metode analitik yaitu metode penelitian yang dilakukan dengan tujuan untuk mengetahui hubungan antara Kualitas tidur dengan kadar glukosa darah puasa pada pasien DM Tipe II. Sampel menggunakan purposive sampling dengan menggunakan rumus Slovin dengan jumlah sampel  55  orang  yaitu  seluruh pasien DM tipe 2 yang menjalani rawat jalan di PKM Kassi-Kassi Kota Makassar. Hasil Uji Statistik Chi Square diperoleh p value 0,000 < 0,05.sehingga peneliti berasumsi bahwa  ada hubungan antara kualitas tidur dengan kadar glukosa darah pada pasien DM Type 2 di Puskesmas Kassi-Kassi Makassar.  Kesimpulan yaitu terdapat hubungan kualitas tidur dengan kadar glukosa darah pada pasien diabetes melitus tipe 2 di Puskesmas Kassi-Kassi Makassar. Saran dapat dijadikan sebagai salah satu acuhan bagi pasien diabetes melitus tipe 2 untuk meningkatkan kualitas tidur dan menjaga kadar glukosa darah puasa

scholarly journals Thyroid hormones profile of patients with type 2 diabetes mellitus in Kano, Nigeria

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Mustapha Zainab Abubakar ◽  
Kabiru Abdulsalam ◽  
Isah A. Yahaya
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Endocrine Disorders ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Type 2 Diabetics ◽  
Patients With Diabetes ◽  
Considerable Impact

Diabetes mellitus (DM) and thyroid disease are the two most common endocrine disorders in the general population. Several Studies have shown that thyroid dysfunction is common in patients with DM, and thyroid dysfunction have been found to have a considerable impact on the glycaemic control and often increases the risk of development of long-term complications in patients with diabetes mellitus. This study determined the prevalence of thyroid dysfunction in patients with type 2 DM in Kano, North-Western Nigeria. The study was a descriptive cross-sectional study conducted on 250 participants made up of 130 patients with type 2 DM and 120 apparently healthy non-diabetic controls. Questionnaires were used to collect information on bio data, medical history, duration of diagnosis of diabetes and type of treatment. Also, blood samples of the participants were collected and analyzed for fasting plasma glucose, fT3, fT4, and TSH. The results were interpreted using American Thyroid Associations’ criteria and the data was analyzed using the statistical software package, STATA version 20. Two hundred and thirty-four (93.6%) of the participants were euthyroid while sixteen (6.4%) were found to have various forms of thyroid dysfunction. The prevalence of thyroid dysfunction was 10% and 2.5% among type 2 diabetics and controls respectively. Among the type 2 DM patients with thyroid dysfunction, 38.5% had hypothyroidism. Thyroid dysfunction was found to be commoner among type 2 DM patients than non-diabetic individuals with hypothyroidism being the commonest disorder.

scholarly journals A Descriptive Study Of Diet In Family Of Patients With Diabetes Mellitus Type 2

2018 ◽  
Vol 1 (1) ◽  
pp. 69
Author(s):  
Citra Windani Mambang Sari ◽  
Fitri Nurul Khotimah ◽  
Sri Pratiwi Hartati
Keyword(s):  
Diabetes Mellitus ◽  
Sampling Technique ◽  
Consumption Pattern ◽  
Fat Intake ◽  
Food Record ◽  
Purposive Sampling ◽  
Type 2 Dm ◽  
The Family ◽  
Diabetes Melitus

Diet is one of the main factors related to various diseases including Diabetes Mellitus (DM). High carbohydrate, fat, protein, and low fiber diets can increase the risk of type 2 DM occurrence, especially in the patient’s family as a risk group. Previous research on students with DM families in Central Java still had a high-calorie food consumption pattern. The diversity of population, culture, and age may affect the results. Therefore, this study aimed to describe the diet in the family of patients with type 2 DM in the working area of Puskemas (Community Health Center) Garuda Bandung.This research used a quantitative descriptive method by purposive sampling technique. The respondents in this study involved 46 people who were the children of type 2 DM patients in the working area of Puskesmas Garuda. Dietary data obtained from the food record sheet for 3 days and was calculated using Nutrisurvey software in kilocalories (kcal) as the unit of measurement then the results were categorized based on Consensus Perkeni 2015. Data analysis was using frequency distribution.The results showed that 39 (84.8%) respondents in the diet category less than body requirements, 37 (80.4%) respondents in the category of sufficient carbohydrate intake, 39 (84.6%) respondents in the category of excess fat intake, 45 (97.8%) respondents in the category of adequate protein intake, and 41 (89.1%) respondents in the category of less fiber.The conclusions from this study that almost all families of patients with type 2 DM in the work area of Puskesmas Garuda were in the diet category less than body requirement but with the excess fat intake and less fiber. Based on these results, the nurses in Puskesmas are expected to optimize the outreach programs by addressing families of DM patients to make the diet as an attempt to prevent the risk in the family of patients with type 2 DM.Key words: Diet, DM patients’ families, food record. Gambaran Diet pada Keluarga Pasien Diabetes Melitus Tipe 2AbstrakDiet adalah salah satu faktor utama yang berhubungan dengan berbagai penyakit termasuk Diabetes Melitus (DM). Diet tinggi karbohidrat, lemak, protein, serta rendah serat dapat meningkatkan risiko kejadian DM tipe 2 terutama pada keluarga pasien sebagai kelompok berisiko. Penelitian sebelumnya pada mahasiswa dengan keluarga DM di Jawa Tengah masih memiliki pola konsumsi makanan yang tinggi kalori. Perbedaan populasi, budaya, serta usia mungkin akan mempengaruhi hasil. Oleh karena itu, tujuan penelitian ini untuk menggambarkan diet pada keluarga pasien DM tipe 2 di wilayah kerja Puskemas Garuda Kota Bandung.Penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik purposive sampling. Responden dalam penelitian ini berjumlah 46 orang yang merupakan anak kandung pasien DM tipe 2 di Wilayah Kerja Puskesmas Garuda. Data diet diperoleh melalui lembar food record selama 3 hari dihitung mengunakan software Nutrisurvey dengan hasil ukur dalam kilokalori (kcal) yang kemudian hasilnya dikategorikan berdasarkan Konsensus Perkeni 2015. Analisis data menggunakan distribusi frekuensi.Hasil penelitian menujukkan bahwa sebanyak 39 (84,8%) responden dalam kategori diet kurang dari kebutuhan, sebanyak 37 (80,4%) responden dalam kategori asupan karbohidrat cukup, sebanyak 39 (84,6%) responden dalam kategori asupan lemak berlebih, sebanyak 45 (97,8%) responden dalam kategori asupan protein cukup, dan 41 (89,1%) responden dalam kategori serat kurang.Simpulan dari penelitian ini bahwa hampir seluruh keluarga pasien DM tipe 2 di wilayah kerja Puskesmas Garuda berada pada kategori diet kurang dari kebutuhan tetapi dengan asupan lemak berlebih dan serat yang kurang. Berdasarkan hasil tersebut, maka perawat puskesmas diharapkan dapat mengoptimalkan program luar gedung dengan menyasar keluarga penderita DM untuk menjadikan diet sebagai upaya untuk mencegah risiko DM pada keluarga pasien DM tipe 2.Kata kunci : Diet, food record, keluarga pasien DM.

scholarly journals Relationship of Type 2 Diabetes Mellitus Duration with The Occurrence of Erectile Dysfunction at Puskesmas Denpasar Barat I

2021 ◽  
Vol 2 (1) ◽  
pp. 23-28
Author(s):  
Alexander Petra Sihite ◽  
I Gusti Ngurah Pramesemara ◽  
I Wayan Surudarma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Number Of Patients ◽  
Relationship Of ◽  
The Relationship

Background: Type 2 diabetes mellitus is a metabolic disease that characterized by high blood sugar levels. This condition is often not noticed immediately and usually patient starting to realize it when complications have been occurred. A long-term complication of type 2 DM that occurred in men is erectile dysfunction (ED). ED is a condition when a person is unable to achieve or maintain an erection for sexual intercourse. One factor that influence the occurrence of ED and its severity in type 2 DM patients is the duration of the disease. Objective: The aim of this study was to determine the relationship of type 2 DM duration and the occurrence of ED. Methods: This study is an observational analytic cross-sectional study conducted at the Puskesmas (Public Health Center) Denpasar Barat I. The research data was obtained through medical record data and fill the International Index of Erectile Function (IIEF-5) questionnaire on 36 type 2 DM patients aged around 40-60 years. The statistical analysis used was Fisher's exact test. Results: The results showed that of the 36 samples, 19 (52.8%) samples had type 2 DM <24 months and 17 (47.2%) samples had type 2 DM >24 months. It was found that 5 (13.9%) samples did not experience ED while the rest experienced ED with different severity. There was a significant relationship between the type 2 DM duration and the occurrence of erectile dysfunction at Puskesmas Denpasar Barat I (p = 0.022). Conclusion: Study has found that type 2 DM patients with the longer duration (>24 months)  have a higher occurrence of ED and tended to be more severe compared to those with shorter duration (<24 months). Further studies should be performed with higher number of patients and more controlled risk factor so it will be more accurate in determining the relationship between the duration of type 2 DM and ED.

The values of cardio-ankle vascular and ankle-brachial indices in patients with carbohydrate metabolic disorders: The ESSE-RF study in the Kemerovo Region

2016 ◽  
Vol 88 (12) ◽  
pp. 11-20 ◽  
Author(s):  
A N Sumin ◽  
N A Bezdenezhnykh ◽  
N V Fedorova ◽  
A V Shcheglova ◽  
E V Indukaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Metabolic Disorders ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
The Russian Federation ◽  
Peripheral Arterial

Aim. To investigate factors associated with pathological cardio-ankle vascular and ankle-brachial indices (CAVI and ABI) in patients with carbohydrate metabolic disorders (CMD). Subjects and methods. A cross-sectional study was conducted in the framework of the multicenter epidemiological study “Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Russian Federation” (ESSE-RF) in March to October 2013. The standard ESSE-RF protocol was extended by an additional study of peripheral arterial stiffness, by estimating CAVI and ABI automatically. A sample of 1619 people was formed in several stages, in which 311 patients with type 2 diabetes mellitus and prediabetes were identified and divided into 3 groups: 1) 41 patients with pathological CAVI values (≥9.0); 2) 241 with normal CAVI (

Deregulated profiles of urinary microRNAs may explain podocyte injury and proximal tubule dysfunction in normoalbuminuric patients with type 2 diabetes mellitus

2017 ◽  
Vol 66 (4) ◽  
pp. 747-754 ◽  
Author(s):  
Oana Milas ◽  
Florica Gadalean ◽  
Adrian Vlad ◽  
Victor Dumitrascu ◽  
Cristina Gluhovschi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Regression Analysis ◽  
Proximal Tubule ◽  
Cross Sectional ◽  
Podocyte Injury ◽  
Podocyte Damage ◽  
Type 2 Dm

MicroRNAs (miRNAs) are short non-coding RNA species that are important post-transcriptional regulators of gene expression. The aim of the study was to establish a potential explanation of podocyte damage and proximal tubule (PT) dysfunction induced by deregulated miRNAs expression in the course of type 2 diabetes mellitus (DM). A total of 68 patients with type 2 DM and 11 healthy subjects were enrolled in a cross-sectional study and assessed concerning urinary albumin:creatinine ratio (UACR), urinary N-acetyl-β-D-glucosamininidase (NAG), urinary kidney injury molecule-1, urinary nephrin, podocalyxin, synaptopodin, estimated glomerular filtration rate (eGFR), urinary miRNA21, miRNA124, and miRNA192. In univariable regression analysis, miRNA21, miRNA124, and miRNA192 correlated with urinary nephrin, synaptopodin, podocalyxin, NAG, KIM-1, UACR, and eGFR. Multivariable regression analysis yielded models in which miRNA192 correlated with synaptopodin, uNAG, and eGFR (R2=0.902; P<0.0001), miRNA124 correlated with synaptopodin, uNAG, UACR, and eGFR (R2=0.881; P<0.0001), whereas miRNA21 correlated with podocalyxin, uNAG, UACR, and eGFR (R2=0.882; P<0.0001). Urinary miRNA192 expression was downregulated, while urinary miRNA21 and miRNA124 expressions were upregulated. In patients with type 2 DM, there is an association between podocyte injury and PT dysfunction, and miRNA excretion, even in the normoalbuminuria stage. This observation documents a potential role of the urinary profiles of miRNA21, miRNA124, and miRNA192 in early DN. Despite their variability across the segments of the nephron, urinary miRNAs may be considered as a reliable tool for the identification of novel biomarkers in order to characterize the genetic pattern of podocyte damage and PT dysfunction in early DN of type 2 DM.

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