scholarly journals Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

2021 ◽  
Vol 5 (2) ◽  
pp. 320-326
Author(s):  
Radema Pranata ◽  
Yuli Kurniawati ◽  
Fitriani ◽  
Legiran ◽  
Soenarto Kartowigno ◽  
...  
Keyword(s):  
Informed Consent ◽  
Kidney Disease ◽  
Serum Level ◽  
Interleukin 2 ◽  
Hemodialysis Patients ◽  
Strong Positive Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
The Mean ◽  
Cross Sectional Design

A B S T R A C TRenal pruritus (RP) is a condition or symptom that is often found in end-stagechronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP ismultifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Studyon the correlation between serum level of IL-2 and the severity of RP is still limited.This study will analyze the correlation between serum level of IL-2 in patientsundergoing HD and the severity of RP. Our method is cross sectional design atHemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale.Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years andwilling to sign informed consent. The results from 28 male (59.6%) and 19 female(40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RPseverity score is 18.98 ± 2.74. A strong positive correlation between serum level ofIL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase ofserum level IL-2 in line with severity of RP.

scholarly journals Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

2021 ◽  
Vol 5 (5) ◽  
pp. 434-440
Author(s):  
Radema Pranata ◽  
Yuli Kurniawati ◽  
Fitriani Fitriani ◽  
Legiran ◽  
Soenarto Kartowigno ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Serum Level ◽  
Interleukin 2 ◽  
Hemodialysis Patients ◽  
Strong Positive Correlation ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
The Mean ◽  
Cross Sectional Design ◽  
End Stage

Renal pruritus (RP) is a condition or symptom that is often found in end-stage chronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP is multifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Study on the correlation between serum level of IL-2 and the severity of RP is still limited. This study will analyze the correlation between serum level of IL-2 in patients undergoing HD and the severity of RP. Our method is cross sectional design at Hemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2 examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale. Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years and willing to sign informed consent. The results from 28 male (59.6%) and 19 female (40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RP severity score is 18.98 ± 2.74. A strong positive correlation between serum level of IL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase of serum level IL-2 in line with severity of RP.

scholarly journals Correlation between Serum Leptin Level with Type and Number of Lesion Skin Tag

2019 ◽  
Vol 7 (1) ◽  
pp. 53-55 ◽  
Author(s):  
Imam Budi Putra ◽  
Remenda Siregar ◽  
Nelva K. Jusuf ◽  
Oratna Ginting ◽  
Raja Nurhayati
Keyword(s):  
Serum Level ◽  
Cross Sectional ◽  
High Positive Correlation ◽  
Serum Leptin ◽  
Positive Correlation ◽  
Skin Tag ◽  
The Mean ◽  
Cross Sectional Design ◽  
Very High ◽  
Lesion Skin

BACKGROUND: Skin tag is a benign tumour of connective tissue in the skin, sessile or pedunculated, skin-like to brownish coloured and often arises in the flexure area. Etiopathogenesis of skin tag is still unclear, but one of the aetiology is associated with leptin hormone. AIM: To determine the correlation between leptin serum level with type and number of the lesion skin tag. METHODS: This study is an observational analytic study with a cross-sectional design involving 33 skin tag patients. Diagnosis of skin tag was based on history and clinical examination; we conducted blood sampling and measurement of serum leptin level to the patients. RESULTS: We found the mean serum leptin level of skin tag patients were highest on the type of lesion mixed (31.54 ± 12.85 ng/ml). The mean number of skin tag lesions was 13.6 ± 5.8 lesions. There is a very high positive correlation between serum leptin level with a number of skin tag (r = 0.86) with p < 0.05 and significant correlation between serum leptin level with the type of lesions (p = 0.037). CONCLUSION: Serum leptin level has a very high positive correlation to a number of skin tag and significant correlation between serum leptin level with the type of lesion.

scholarly journals Comparison of Gates’ Method and CKD-EPI Equation with Plasma Sample Method for Estimation of GFR

2019 ◽  
Vol 22 (1) ◽  
pp. 36-40
Author(s):  
Suraya Sarmin ◽  
Sadia Sultana ◽  
Madhuchhanda Hazra Mou ◽  
Naheed Khan ◽  
Pupree Mutsuddy ◽  
...  
Keyword(s):  
Gold Standard ◽  
Filtration Rate ◽  
Plasma Sample ◽  
Strong Positive Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Disease Epidemiology ◽  
Plasma Sample Method ◽  
The Mean ◽  
Sample Method

Objectives: Glomerular Filtration Rate (GFR) is an important parameter of kidney function. Many methods are used to measure GFR namely: inulin clearance, double plasma sample method (DPSM), Gates’ method, and equation based method. DPSM has become the gold standard in clinical research. Gates’ method is routinely practiced at National Institute of Nuclear Medicine and Allied Sciences. Chronic kidney disease epidemiology collaboration (CKD-EPI ) equation is encouraged as it is simple and reliable. The aim of the study was assesment of agreement between Gates’ method and CKD-EPI equation with plasma sample method for estimation of GFR. Patients and methods: This cross sectional observational study was carried out at NINMAS, during July 2017 to June 2018. A total of 70 subjects referred for 99mTC-DTPA renography along with GFR estimation, were included in this study. Result: The mean GFR value evaluated by DPSM, Gates’ and CKD-EPI  equation were, 81.86 ± 22.42, 86.13 ± 26.70 and 78.48 ± 23.87 mL/min/1.73 m2 respectively. A strong positive correlation (r = 0.922) was found between DPSM and Gates’ method and also between DPSM and CKD-EPI equation (r= 0.930). The Gates’ and CKD-EPI equation also showed strong positive correlation (r = 0.872). The mean difference between DPSM and Gates’, between DPSM and CKD-EPI equation,  between Gates’ and CKD-EPI equation were 4.26 ± 10.45, 3.38 ± 8.78  and  7.64 ± 13.09 mL/min/1.73 m2 respectively. Conclusion: Strong positive correlation and excellent agreement were observed between DPSM and Gates’ and also between DPSM and CKD-EPI equation. Strong correlation was also found in between Gates’ and CKD-EPI equation. So, DPSM, Gates’ method and CKD-EPI equation can reflect GFR almost equally and used interchangeably. Bangladesh J. Nuclear Med. 22(1): 36-40, Jan 2019  

scholarly journals Status of Chronic Kidney Disease Patients Registered in National Kidney Center, Banasthali, Kathmandu

2015 ◽  
Vol 1 (4) ◽  
pp. 19-23 ◽  
Author(s):  
D Mishra ◽  
P Koirala
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Preventive Measures ◽  
Public Health Problem ◽  
Medication Cost ◽  
Cross Sectional ◽  
Average Patient ◽  
The Mean ◽  
Cross Sectional Design ◽  
The Needy

Chronic kidney disease is a worldwide public health problem. In Nepal, Chronic kidney disease patients are increasing and the management of this disease is very expensive compared to other chronic diseases? We assessed the socioeconomic status of chronic kidney disease patients registered in National Kidney Centre, Banasthali, Kathmandu. The study used descriptive cross sectional design. Ninety six samples were collected between 15- 31 October, 2012.The mean age of the patients was 47 years, with almost half of the patients (46%) from 41-60 years age group. Among the patients, 65 % were male, 85% were married, 80% were literate, 57% were past smoker and 75% were drinker and 59% were from Kathmandu valley. Likewise, most of them were Newar, work as housewife as the main occupation. One third (37%) had to sell their property for the treatment. On an average patient spent Rs.240000 per year in dialysis. Similarly, medication cost was Rs.180000 and transplantation cost was Rs.500000 to 1000000. Preventive measures of the disease and subsidy in the treatment will be beneficial for the needy people. DOI: http://dx.doi.org/10.3126/jmmihs.v1i4.11997Journal of Manmohan Memorial Institute of Health Sciences Vol. 1, Issue 4, 2015Page : 19-23 

scholarly journals Serum Hepcidin as an Inflammatory Marker in Chronic Kidney Disease

2020 ◽  
pp. 40-45
Author(s):  
Jyothi Elizabeth Roy ◽  
B. Shanthi ◽  
V. S. Kalai Selvi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iron Homeostasis ◽  
Inflammatory Marker ◽  
The Body ◽  
Strong Positive Correlation ◽  
Cross Sectional ◽  
Mean Values ◽  
Serum Hepcidin ◽  
The Mean

Background: Hepcidin is known to be the central regulator of iron homeostasis in the body. It is up-regulated by inflammation and downregulated by anemia. CKD is a state of chronic inflammation seen in kidney. Previous work has shown that serum hepcidin levels were increased in patients with CKD. This was surprising as these patients had a chronic inflammatory state and co-existent anemia. Aim and Objectives: The aim of the study is to estimate the levels of hepcidin in CKD patients and to check the correlation of hepcidin to inflammation in chronic kidney disease. Methods: This cross-sectional study was conducted at the Department of Biochemistry, Central Laboratory, Sree Balaji Medical College and Hospital, Chromepet, Chennai during January 2017 - June 2018 among 50 patients of chronic kidney disease in the age group of 18-60 years. The blood samples were collected using vacutainer system. Samples for serum hepcidin, ferritin and hsCRP were collected in red topped plain vacuum tube. The samples were centrifuged at 3000 rpm for 15 minutes. The samples were then processed, and values were obtained. The data were analysed using SPSS package. Results: The mean values of s. Hepcidin, s. ferritin and hsCRP levels were found to be increased in the study population. The mean value of s. hepcidin was found to have strong positive correlation with the mean values of s. ferritin and hsCRP with r-value > 0.7. Conclusion: Hepcidin levels are elevated in CKD and hepcidin is a predictor of inflammation since it correlated well with the inflammatory markers hsCRP and ferritin levels.

scholarly journals Vancomycin dosing in low-flux hemodialysis; is adjustment of drug dosage necessary?

2018 ◽  
Vol 8 (2) ◽  
pp. 112-115
Author(s):  
Niloofar Khodabandehloo ◽  
Arash Fourodi ◽  
Aria Jenabi
Keyword(s):  
Serum Level ◽  
Drug Dosage ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Dialysis Session ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gram Positive Bacteria ◽  
Before And After ◽  
The Mean

Introduction: Vancomycin is a wide useable antibiotic against gram-positive bacteria species in different clinical setting particularly in hemodialysis patients. Objectives: The present study aimed to assess the serum level of vancomycin before and after hemodialysis. Patients and Methods: This cross-sectional study was performed on patients who were hospitalized and medicated by vancomycin with the loading dose of 1000 mg followed by the maintenance dose of 500 mg after each dialysis session every other day. All patients were dialyzed with a low-flux dialyzer membrane. Half an hour before and immediately after dialysis, 2 mL blood sample was taken and stored at -20°C until assaying the level of vancomycin. Results: The average reduction in the serum level of vancomycin was totally 17.65 ± 1.69%. The mean reduction in the serum level of vancomycin was significantly higher in the patients aged higher than 60 years, as compared to other ones. But the level of drug was independent to gender or body mass index. Conclusion: Using low-flux dialyzer membranes, the average reduction in the serum level of vancomycin is expected to be in the range of 12.43% to 21.56% that age was directly associated with the average reduction of the level of vancomycin. Therefore, adjusting and monitoring the serum level of drug in old ages even in the cases of using low-flux dialyzer membranes is recommended.

scholarly journals MO918INFECTIOUS COMPLICATIONS IN HEMODIALYSIS: INTERSET OF NEUTROPHIL TO LYMPHOCYTE AND PLATELETS TO LYMPHOCYTE RATIOS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Rania Lahouimel ◽  
Toumi Salma ◽  
Hanen Abid ◽  
Emna Kharrat ◽  
Amira Saai ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Infectious Complications ◽  
Chronic Hemodialysis ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Literature Reviews ◽  
History Of ◽  
The Mean ◽  
One Year

Abstract Background and Aims Infectious complications represent the leading cause of death among the dialysis population, prompting early diagnosis and increased vigilance. Neutrophil-to-lymphocyte and platelets-to-lymphocyte ratios are newly emerging as more accessible and simple markers for the detection of the onset of infections. The objective of our study is to prove the value of these markers in the diagnosis of infections in hemodialysis patients. Method This is a cross-sectional study spread over one year including 85 chronic hemodialysis patients with duration of at least 6 months. patients with hemopathies, tumors, or with a history of hospitalization during the 3 months before the study were excluded. CRP was used as a biomarker of infections and N / L; P / L ratios were calculated to study the correlation between the two biomarkers. Based on the literature reviews, the threshold of the N / L ratio and the P / L ratio admitted for our stydy were respectively : &gt; = 2.5 and &gt; = 150. Results The mean age of our patients was 49 ± 19 years with a predominance of women (55%) .The average duration in hemodialysis was 67.2 months. An infectious complication was noted in 22% of our patients whose distribution was as follow: 4% as a pulmonary infection with 3 coronavirus cases, 6% a sepsis, one case of abscess of the nephrectomy compartment.The median value of the CRP was 37±10mg/l We found a positive correlation between the 2 ratios associated (RNL and RPL) and infection with (p = 0.03) . We noted throw this study that patients with both high ratios RPL&gt; 150 and RNL&gt; 2.5 have significantly elevated values of CRP. Conclusion N/L and P/L ratios are easy-to-calculate markers that are of great benefit to the hemodialysis population. We have shown through this study the existence of a positive correlation between the N/L and P/L ratios and the occurrence of infections in hemodialysis patients. We therefore encourage the use of this ratios to be included as markers to detect infections occurence.

scholarly journals Cystatin C Serum Level and the Severity of Preeclampsia

2017 ◽  
pp. 133
Author(s):  
Abraham Winarto ◽  
Eddy Suparman ◽  
John Wantania
Keyword(s):  
Serum Level ◽  
Serum Concentration ◽  
Pregnant Women ◽  
Cystatin C ◽  
Statistical Test ◽  
Severe Preeclampsia ◽  
Cross Sectional ◽  
Mild Preeclampsia ◽  
The Mean ◽  
Cross Sectional Design

Objective: Determining the cystatin C serum level among normotensive, mild preeclamptic, severe preeclamptic pregnant women and their relationship with the severity of preeclampsia. Method: The study was held using cross sectional design in Prof. Dr. RD Kandou Hospital in Manado and its network hospitals. We did on 51 samples at term pregnant women, consisting of 17 samples for each group in normotensive, mild preeclampsia, and severe preeclampsia. The data were analyzed using SPSS version 22.0 software through ANOVA and Kruskal Wallis statistical test. Result: The mean cystatin C serum concentration in normotensive pregnant women, mild preeclampsia, and severe preeclampsia were 0.82 mg/l, 1.03 mg/l, and 1.32 mg/l; respectively. The ANOVA statistical test showed the significant association between cystatin C level and severity of preeclampsia (p

Relationship of Sense of Coherence to Other Psychosocial Indices

2004 ◽  
Vol 20 (4) ◽  
pp. 227-236 ◽  
Author(s):  
Sara Holmberg ◽  
Anders Thelin ◽  
Eva-Lena Stiernström
Keyword(s):  
Social Support ◽  
Psychosocial Factors ◽  
Sense Of Coherence ◽  
Living Conditions ◽  
Strong Negative Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Work Related ◽  
Job Demand ◽  
The Mean

Summary: The concept of “sense of coherence” (SOC) has been widely recognized since it was first introduced by Antonovsky. The originality and usefulness of the SOC scale and its relation to other psychosocial measures has been the subject of lively debate. The aim of this paper was to test for associations between SOC and work-related psychosocial factors (mainly the Job Demand-Control model), general living conditions, education, and social network factors. Cross-sectional data from a population-based sample of 1782 rural males from nine counties in Sweden were analyzed with a multiple regression technique. The subjects were occupationally active at inclusion and the mean age was 50 years (range 40-60). SOC was assessed with the original 29-item questionnaire. Psychosocial variables and lifestyle factors were assessed using questionnaires and structured interviews. The mean SOC among the subjects was 152.3 (standard deviation, 19.4). A strong negative correlation was found between SOC and job demand, whereas a positive correlation with job control was demonstrated. A positive correlation with general living conditions and with social support was also found. However, there was no correlation to education and occupation. Thus, SOC was shown to be strongly correlated to work-related psychosocial factors and social support, but independent of sociodemographic factors.

Associations of cardiovascular disease and blood pressure with cognition in hemodialysis patients: The Osaka Dialysis Complication Study

2021 ◽  
Author(s):  
Tetsuo Shoji ◽  
Hisako Fujii ◽  
Katsuhito Mori ◽  
Shinya Nakatani ◽  
Yuki Nagata ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diastolic Pressure ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Cross Sectional ◽  
Diabetic Kidney ◽  
Prior Stroke

Abstract Background Previous studies reported mixed results regarding the contributions of cardiovascular disease (CVD) and blood pressure to cognitive impairment in chronic kidney disease. Methods This was a cross-sectional study in 1213 patients on maintenance hemodialysis from 17 dialysis units in Japan. The main exposures were prior CVD and blood pressure components including systolic (SBP) and diastolic pressure (DBP). The outcome was low cognitive function evaluated with the Modified Mini-Mental State examination (3MS) with a cut-off level of 3MS &lt; 80. Results The median age was 67 years, median duration of dialysis was 71 months, 37% were women, 39% had diabetic kidney disease, and 36% had any pre-existing CVD. Median (interquartile range) of 3MS score was 91 (82 to 97), and 240 patients (20%) had 3MS &lt; 80. Logistic regression analysis showed that 3MS &lt; 80 was associated with the presence of any prior CVD, particularly prior stroke. 3MS &lt; 80 was associated with lower DBP but not with SBP. When patients were stratified by the presence of prior stroke, lower DBP, higher age, and lower education level were factors associated with 3MS &lt; 80 in both subgroups. In the subgroup of patients without prior stroke, diabetic kidney disease was an additional factor associated with 3MS &lt; 80. CVDs other than stroke were not associated with 3MS in either subgroup. Conclusions Prior stroke and lower DBP were associated with 3MS &lt; 80 in hemodialysis patients. These findings support the hypothesis that these vascular factors contribute to low cognitive performance in patients undergoing hemodialysis.

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