scholarly journals Radiolabeled curcumin as β amyloid imaging and tumor targeting imaging agents

2021 ◽  
Vol 8 (3) ◽  
pp. 5-11
Author(s):  
Nurmaya Effendi
Keyword(s):  
Tumor Targeting ◽  
Tumor Imaging ◽  
Curcuma Longa ◽  
Pharmacological Action ◽  
Amyloid Imaging ◽  
Imaging Agents ◽  
Molecular Imaging Agents ◽  
Β Amyloid ◽  
Iodine 125 ◽  
Gallium 68

Curcumin, a polyphenolic compound, derived from the rhizomes of Curcuma longa L. Curcumin shows potential pharmacological action against numerous disorders, including cancer, neurodegenerative, and infection diseases. Curcumin-based molecular imaging agents could be useful for early detection of Alzheimer Disease and tumor and monitor the progress of therapy. Radiolabeled curcumin and its derivatives become promising compounds as imaging agents. In this review, radiolabeled curcumin bearing radionuclides including fluorine-18, Technetium-99m, Iodine-125, and Gallium-68 are reviewed as an effort to develop curcumin-based probes not only for β amyloid imaging but also for tumor imaging.

Synthesis and biological evaluation of curcumin analogs as β-amyloid imaging agents

2017 ◽  
Vol 9 (14) ◽  
pp. 1587-1596 ◽  
Author(s):  
Changsheng Gan ◽  
Jingyi Hu ◽  
Dou-Dou Nan ◽  
Shanshan Wang ◽  
Hong Li
Keyword(s):  
Biological Evaluation ◽  
Amyloid Imaging ◽  
Imaging Agents ◽  
Curcumin Analogs ◽  
Β Amyloid ◽  
Synthesis And Biological Evaluation

scholarly journals Biological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents

2019 ◽  
Vol 1189 ◽  
pp. 012038
Author(s):  
V K Tishchenko ◽  
V M Petriev ◽  
A A Mikhailovskaya ◽  
K A Kuzenkova ◽  
A D Kaprin ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Biological Evaluation ◽  
Imaging Agents ◽  
Gallium 68

Synthesis and characterization of styrylchromone derivatives as β-amyloid imaging agents

2007 ◽  
Vol 15 (1) ◽  
pp. 444-450 ◽  
Author(s):  
Masahiro Ono ◽  
Yoshifumi Maya ◽  
Mamoru Haratake ◽  
Morio Nakayama
Keyword(s):  
Amyloid Imaging ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Β Amyloid

scholarly journals A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

2020 ◽  
Vol 13 (8) ◽  
pp. 199
Author(s):  
Joseph Lau ◽  
Julie Rousseau ◽  
Daniel Kwon ◽  
François Bénard ◽  
Kuo-Shyan Lin
Keyword(s):  
Molecular Imaging ◽  
Smooth Muscle Contraction ◽  
Therapeutic Interventions ◽  
Imaging Agents ◽  
Kinin System ◽  
Normal Tissues ◽  
Molecular Imaging Agents ◽  
Inflammatory State ◽  
B2 Receptors ◽  
Tissue Trauma

Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention, smooth muscle contraction, and algesia, while B1R is absent in normal tissues and is induced by tissue trauma or inflammation. B2R is activated by kinins, while B1R is activated by kinins that lack the C-terminal arginine residue. Perturbations of the kinin system have been implicated in inflammation, chronic pain, vasculopathy, neuropathy, obesity, diabetes, and cancer. In general, excess activation and signaling of the kinin system lead to a pro-inflammatory state. Depending on the disease context, agonism or antagonism of the bradykinin receptors have been considered as therapeutic options. In this review, we summarize molecular imaging agents targeting these G protein-coupled receptors, including optical and radioactive probes that have been used to interrogate B1R/B2R expression at the cellular and anatomical levels, respectively. Several of these preclinical agents, described herein, have the potential to guide therapeutic interventions for these receptors.

ChemInform Abstract: POTENTIAL ORGAN OR TUMOR-IMAGING AGENTS. 16. FLUORINATED ANDROSTANES AND THE PROSTATE

1978 ◽  
Vol 9 (34) ◽  
Author(s):  
A. CASTONGUAY ◽  
R. E. COUNSELL ◽  
R. W. S. SKINNER ◽  
R. V. POZDERAC
Keyword(s):  
Tumor Imaging ◽  
Imaging Agents

Novel imaging agents for β-amyloid plaque based on the N-benzoylindole core

2011 ◽  
Vol 21 (18) ◽  
pp. 5594-5597 ◽  
Author(s):  
Yang Yang ◽  
Xin-Hong Duan ◽  
Jun-Yuan Deng ◽  
Bing Jin ◽  
Hong-Mei Jia ◽  
...  
Keyword(s):  
Amyloid Plaque ◽  
Imaging Agents ◽  
Β Amyloid

scholarly journals Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH+ Cancer Cells in MRI

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Milad Yousefvand ◽  
Zahra Mohammadi ◽  
Farzaneh Ghorbani ◽  
Rasoul Irajirad ◽  
Hormoz Abedi ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Tumor Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Gnrh Receptors ◽  
Imaging Probes ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Contrast Agent

In recent years, the conjugation of superparamagnetic iron oxide nanoparticles (SPIONs), as tumor-imaging probes for magnetic resonance imaging (MRI), with tumor targeting peptides possesses promising advantages for specific delivery of MRI agents. The objective of the current study was to design a targeted contrast agent for MRI based on Fe3O4 nanoparticles conjugated triptorelin (SPION@triptorelin), which has a great affinity to the GnRH receptors. The SPIONs-coated carboxymethyl dextran (SPION@CMD) conjugated triptorelin (SPION@CMD@triptorelin) were synthesized using coprecipitation method and characterized by DLS, TEM, XRD, FTIR, Zeta, and VSM techniques. The relaxivities of synthetized formulations were then calculated using a 1.5 Tesla clinical magnetic field. MRI, quantitative cellular uptake, and cytotoxicity level of them were estimated. The characterization results confirmed that the formation of SPION@CMD@triptorelin has been conjugated with a suitable size. Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. The relaxivity calculations for SPION@CMD@triptorelin showed a suitable r2 and r2/r1 with values of 31.75 mM−1·s−1 and 10.26, respectively. Our findings confirm that triptorelin-targeted SPIONs could provide a T2-weighted probe contrast agent that has the great potential for the diagnosis of GnRH-positive cancer in MRI.

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