Analgesic and Diuretic Activity of Curcuma xanthorrhiza

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
MK Hassan Mahmood ◽  
Sitesh Chandra Bachar ◽  
Md Saiful Islam ◽  
Mohammad Shawkat Ali
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Oral Administration ◽  
Crude Extract ◽  
Methanol Extract ◽  
Test Sample ◽  
Diuretic Effect ◽  
Diuretic Activity ◽  
Curcuma Xanthorrhiza ◽  
Oral Doses

The methanol extract of the dried rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) showed significant analgesic and diuretic activities on Swiss albino mice. Oral administration of the crude extract at doses of 150 and 300 mg/kg body weight, exhibited 33.2 and 50.5% inhibition of acetic acid induced writhing in mice, respectively. Similar oral doses of the extract produced a maximum of 1.24 and 1.45 diuretic activity after 2 and 1 h of the study, respectively. The diuretic effect of the extract started after 1 h at doses of 150 and 300 mg/kg body weight of mice. It was observed that the diuretic activity increased with increasing the concentration of the test sample. Key words: Curcuma xanthorrhiza, Analgesic activity, Diuretic activity. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

2016 ◽  
Vol 19 (2) ◽  
pp. 215-218
Author(s):  
Md Rahatullah Razan ◽  
Muhammed Mahfuzur Rahman ◽  
Faiza Tahia ◽  
Md Khalid Hossain ◽  
Mohammad A Rashid
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Activity Assay ◽  
Swiss Albino Mice

The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oil- induced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectivelyBangladesh Pharmaceutical Journal 19(2): 215-218, 2016

Acute Oral Toxicity Study of Asiasari radix Extract in Mice

2007 ◽  
Vol 26 (3) ◽  
pp. 247-251 ◽  
Author(s):  
T. Ramesh ◽  
K. Lee ◽  
H. W. Lee ◽  
S. J. Kim
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Food Consumption ◽  
Methanol Extract ◽  
The Body ◽  
Toxicity Study ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Organ Weights ◽  
Icr Mice

Acute oral toxicity of methanol extract of Asiasari radix was evaluated in ICR mice of both sexes. In this study, mice were administrated orally with dosages of 1000, 3000, and 5000 mg/kg body weight of Asiasari radix extract. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days post treatment of Asiasari radix extract. No mortality, signs of toxicity, and abnormalities in gross findings were observed. In addition, no significant differences were noticed in the body and organ weights between the control and treated groups of both sexes. These results show that the methanol extract of Asiasari radix is toxicologically safe by oral administration.

scholarly journals Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils ofDioscorea bulbiferaL. varsativa(Dioscoreaceae) in Mice and Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
M. Mbiantcha ◽  
A. Kamanyi ◽  
R. B. Teponno ◽  
A. L. Tapondjou ◽  
P. Watcho ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Oral Administration ◽  
Inflammatory Mediators ◽  
Methanol Extract ◽  
Inflammatory Activity ◽  
Maximum Effect ◽  
Methanol Extracts ◽  
Paw Oedema ◽  
Dioscorea Bulbifera ◽  
Anti Inflammatory

The aqueous and methanol extracts from the dry bulbils ofDioscorea bulbiferaL. var sativa (Dioscoreaceae)—evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils ofDioscorea bulbiferavar sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins. Thus, the analgesic activity of the bulbils ofDioscorea bulbiferamay be at least partially linked to its anti-inflammatory activity.

scholarly journals Bioactivities of Chukrasia tabularis (A. Juss.)

2015 ◽  
Vol 18 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Sharmin Aktar ◽  
Marzia Bilkiss ◽  
Faiza Tahia ◽  
Md Al Amin Sikder ◽  
Ridwan B Rashid ◽  
...  
Keyword(s):  
Body Weight ◽  
Free Radical ◽  
Analgesic Activity ◽  
Crude Extract ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Soluble Fraction ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Chukrasia Tabularis

The methanol extracts of bark and leaves of Chukrasia tabularis and their organic and aqueous soluble materials were subjected to screenings for antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial, analgesic and antidiarrhoel activities. In the DPPH free radical scavenging assay, the methanolic extract of bark of C. tabularis and the aqueous soluble fraction of methanol extract of leaves of C. tabularis revealed the highest free radical scavenging activity with IC50 values of 2.95 ?g/ml and 5.31 ?g/ml, respectively. The pet ether soluble fraction of methanolic extract of leaves and bark of C. tabularis displayed the highest cytotoxic potential having LC50 values 0.0167 ?g/ml and 3.89 ?g/ml, as compared to standard vincristine sulphate (LC50 value of 0.45 ?g/ml). During thrombolytic assay, the aqueous soluble fraction of leaves and carbon tetrachloride soluble fraction of bark of C. tabularis showed 34.04% and 56.37% clot lysis, respectively. In the membrane stabilizing assay, the carbontetrachloride and aqueous soluble materials of methanol extract of leaf inhibited 21.03% and 49.68% hypotonic solution- and heat-induced haemolysis of RBC, respectively. The crude extract of leaves of C. tabularis exhibited mild antibacterial activity, while that of leaves and bark revealed significant central analgesic activity at 400 mg/kg body weight. The crude extracts demonstrated significant peripheral analgesic activity at 200- and 400- mg/kg body weight. On the other hand, the crude extract of leaves of C. tabularis revealed significant antidiarrhoel activity.Bangladesh Pharmaceutical Journal 18(2): 126-131, 2015

Oral and Dermal Pharmacokinetics of Triclopyr in Human Volunteers

1989 ◽  
Vol 8 (6) ◽  
pp. 431-437 ◽  
Author(s):  
N.G. Carmichael ◽  
R.J. Nolan ◽  
J.M. Perkins ◽  
R. Davies ◽  
S.J. Warrington
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Time Course ◽  
Compartment Model ◽  
Dermal Absorption ◽  
Blood Levels ◽  
Human Volunteers ◽  
Applied Dose ◽  
Dermal Pharmacokinetics ◽  
Oral Doses

Blood levels and urinary excretion of triclopyr, the active ingredient in Garlon® herbicides, were followed in six volunteers given single oral doses of 0.1 and 0.5 mg/kg body weight. Five of these volunteers later received dermal applications of Garlon 4 herbicide formulation equivlant to 3.7 mg triclopyr/kg body weight applied to the forearm. Following oral administration blood levels peaked at 2-3 h and declined to undetectable levels within 48 h; more than 80% of. the dose was found as unchanged triclopyr in the urine. A two-compartment pharmacokinetic model was used to describe the time-course of triclopyr clearance; half-lives for the rapid initial and slower terminal phases were 1.3 h and 5.1 h respectively, and were independent of dose. Due to the slow half-life for dermal absorption (t½ = 16.8 h) the rapid initial elimination phase was obscured and the pharmacokinetics could be simplified by a one-compartment model. An average of 1.37% of the applied dose was recovered in the urine; when corrected for recovery after oral administration this was equivalent to an absorption of 1.65%. Triclopyr is slowly absorbed through skin and is rapidly eliminated. It has very low potential to accumulate in man or to be absorbed through the skin in acutely toxic amounts.

scholarly journals Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Amjad Ali ◽  
Abdul Nasir ◽  
Syed Wadood Ali Shah ◽  
Atif Ali Khan Khalil ◽  
Mi-jeong Ahn ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Crude Extract ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Analgesic Effects ◽  
Test Models ◽  
Antinociceptive Effects ◽  
Tail Immersion

Abstract Background In order to find a new natural resource for pain-relief, the analgesic effects of Ilex dipyrena crude extract, fractions, and subfractions were evaluated in in-vivo mouse models with possible mechanism of action. Methods Analgesic effects of crude extract (100 and 200 mg/kg body weight), fractions and subfractions (75 mg/kg body weight) were screened using heat-induced (tail-immersion and hot plate test) and chemical-induced (formalin and acetic acid) nociception models in mice. The samples were also tested for the elucidation of a possible mechanism through opioidergic and GABAergic systems. Results The administration of crude extract, fractions and subfractions produced analgesic responses in acetic acid, formalin, tail immersion, and hot plate model for pain similar to those obtained with the standard. Naloxone antagonized the antinociceptive effects of the tested samples, whereas bicuculline showed partial inhibition. Considering the analgesic response, crude extract, fractions, and subfractions demonstrated promising inhibitory activity against all test models for pain, which was further supported by the possible involvement of opioidergic and GABAergic systems. Conclusion The results suggest that this plant may be useful in the development of new analgesic drugs. Further research with regard to the isolation of bioactive compounds is required to verify these findings.

scholarly journals EFFECT OF AQUEOUS CRUDE EXTRACT OF ALOE VACILLANS LEAVES ON INDUCED HEPATIC DAMAGE IN MALE RABBITS

2021 ◽  
Vol 2 (1) ◽  
pp. 01-06
Author(s):  
Mohammed Ali Qassem
Keyword(s):  
Body Weight ◽  
Carbon Tetrachloride ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Crude Extract ◽  
Total Protein ◽  
Treated Group ◽  
Hepatic Damage ◽  
Serum Parameters ◽  
Protein Levels

This study was designed to evaluate the effects of aqueous extract of Aloe vacillans leaves juice on carbon tetrachloride (CCl4)- induced hepatotoxicity in rabbits. Hepatotoxicity was induced in rabbits by intraperitoneal injection of (CCl4) at dose l ml/kg on day 7 and 8.The aqueous crude extract of Aloe vacillans leaves was administrated at dose 100 mg,300 mg and 500 mg/kg of body weight pass orally (p.o) daily for 8 days. The hepatotoxicity and its prevention were assessed by serum parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin (Bil) and total protein (T.P). In CCl4 treated rabbits, a significant, increasing the ALT, AST, bilirubin and decreasing the Total protein levels were shown (p<0.05), due to liver damage, when compared with the normal group.Treatment with the aqueous extract of Aloe vacillans could significantly decrease the (ALT), (ALT) and bilirubin, increased T.P in serum at p< 0.05 when compared with CCl4 –treated group The data concluded that oral administration of aqueous extract of the leaves of Aloe vacillans significantly decreases the intensity of hepatic damage induced by CCl4 in rabbits.

scholarly journals INVESTIGATION ON IN VIVO ANALGESIC ACTIVITY OF METHANOL EXTRACT OF MARINE BROWN ALGA SPATOGLOSSUM ASPERUM J. AGARTH

2018 ◽  
Vol 11 (11) ◽  
pp. 313
Author(s):  
Pandithurai M ◽  
Murugesan S ◽  
Sivamurugan V
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Brown Alga ◽  
Methanol Extract ◽  
Albino Rats ◽  
Significant Activity ◽  
Study Evaluation ◽  
Wistar Albino Rats

Objective: In the present study, evaluation of the methanol extract of Spatoglossum asperum, brown marine algae on the analgesic activity using animal model was focussed.Methods: Acetic acid-induced writhing test on Wistar albino rats at a dosage of 10 mg/kg body weight of algal extract have been carried out. It showed significant analgesic activity by reducing the number of acetic acid-induced writhing.Results: The animals at a dosage of 10 mg/kg body weight exhibited, 70.52% of the animals were protected using S. asperum extract, on the other hand, the standard, diclofenac protected 84.21% of the animals. The results are statistically significant at p<0.001, and the investigation revealed dose-dependent significant activity in comparison with standard and control.Conclusion: Hence, it can be concluded that the methanol extracts of the brown alga S. asperum have potent analgesic activity at moderate doses.

scholarly journals In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

2016 ◽  
Vol 19 (2) ◽  
pp. 185-189
Author(s):  
Sabikunnahar Papia ◽  
Muhammed Mahfuzur Rahman ◽  
Md Mustafezur Rahman ◽  
Mohaiminul Adib ◽  
Mohammad Firoz Khan
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Methanol Extract ◽  
Hypotonic Solution ◽  
Mice Model ◽  
Immersion Method ◽  
Tail Immersion ◽  
Crude Methanol Extract

Boehmeria glomerulifera Miq. is an indigenous plant of Bangladesh. Traditional healers use this plant to treat various diseases. The crude methanol extract of whole plant of B. glomerulifera and its Kupchan fractions were screened for in vitro membrane stabilizing and only the crude extract at doses of 200- and 400- mg/kg body weight were screened for analgesic activity in mice model in order to establish the medicinal values of this plant. The membrane stabilizing activity of the extractives was evaluated by the ability of test materials to inhibit hypotonic solution- and heat-induced haemolysis of human erythrocytes. Moreover, the analgesic activity of methanol extract was evaluated by acetic acid induced writhing method and tail immersion method in mice. In hypotonic solution- and heat-induced conditions, the crude methanol extract showed inhibition of haemolysis by 64.80±0.34% and 21.63±0.76%, respectively as compared to 77.74±0.67% and 40.41±0.69% demonstrated by the standard, acetyl salicylic acid. On the other hand, the analgesic activity was determined for its peripheral and central pharmacological responses using acetic acid-induced writhing test and tail immersion method at doses of 200- and 400- mg/kg body weight. The extract reduced the acetic acid-induced writhings significantly (p < 0.05) in a dose dependent manner with the highest activity observed at 400 mg/kg (46.0%) body weight when compared to that of Diclofenac sodium (64.0%), as the standard drug. A significant increase (p < 0.01) of latency period was also found in tail immersion method. Therefore, the present study established that the methanol extract of B. glomerulifera possesses moderate membrane stabilizing and significant analgesic activities.Bangladesh Pharmaceutical Journal 19(2): 185-189, 2016

Analgesic Activity of the Rhizomes of Curcuma zedoaria

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
Mohammad Shawkat Ali ◽  
ASM Masum ◽  
Sitesh C Bachar ◽  
Md. Saiful Islam
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Oral Administration ◽  
Analgesic Activity ◽  
Full Text ◽  
Significant Activity ◽  
Curcuma Zedoaria ◽  
Methanol Extracts ◽  
Successive Extraction ◽  
Activity Screening

Successive extraction of the dried rhizomes of Curcuma zedoaria Rosc. provided hexane, chloroform and methanol extracts. In analgesic activity screening, the chloroform and methanol extracts showed significant activity on Swiss albino mice. Oral administration of the crude extracts at a dose of 400 mg/kg body weight, exhibited 29.5 and 38.0 % inhibition of acetic acid induced writhing in mice, respectively while the hexane extract showed weak analgesic activity in the experiment. Key words: Curcuma zedoaria, Zingiberaceae, Analgesic activity. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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