scholarly journals Evaluation of antibacterial efficacy and healing with cyanoacrylate tissue adhesive after periodontal flap surgery

2019 ◽  
pp. 12-17
Author(s):  
Aditi Mahajani ◽  
Menaka K.B ◽  
Sayed Asem Ahmed Jagirdar ◽  
Manjula Vagrali ◽  
Renuka Metgud ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Antibacterial Properties ◽  
Tissue Adhesive ◽  
Antibacterial Efficacy ◽  
Flap Surgery ◽  
Tissue Adhesives ◽  
Bacterial Colony ◽  
Post Surgery ◽  
Periodontal Flap Surgery

Surgical pocket therapy entails raising a mucoperiosteal flap in order to carry out effective debridement so as to eliminate periodontal pockets and result in a healthy periodontium. Braided silk is the most commonly used suture material following periodontal flap surgery. Cyanoacrylate tissue adhesives are slowly gaining popularity as wound closure agents. OBJECTIVES: To evaluate the antibacterial and healing properties of cyanoacrylate tissue adhesives following periodontal flap surgery. METHODS: Patients undergoing full mouth periodontal flap surgery were randomly selected for placement of cyanoacrylates or silk sutures using split mouth study design. Wound healing was evaluated at 1 week using Early Wound Healing Index. Supragingival pooled plaque samples were collected for analysis of total bacterial count at 1week follow up using lawn cultures in blood agar. Pain and burning sensation with cyanoacrylates during and post surgery was recorded using a questionnaire. RESULTS: Silk sutures showed improved wound healing when compared with cyanoacrylates. However, use of cyanoacrylates resulted in reduced bacterial colony counts thereby exhibiting antibacterial properties. Enhanced patient compliance was noted with cyanoacrylate tissue adhesives. SIGNIFICANCE: Cyanoacrylates can be used as an alternative to silk sutures for periodontal wound closure. KEY WORDS: Cyanoacrylate tissue adhesive, silk sutures, antibacterial efficacy, wound healing

scholarly journals Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

2020 ◽  
Vol 4 (2) ◽  
pp. 32
Author(s):  
Amal Narayanan ◽  
Ying Xu ◽  
Ali Dhinojwala ◽  
Abraham Joy
Keyword(s):  
Wound Closure ◽  
Photochemical Reactions ◽  
Cohesive Strength ◽  
Tissue Adhesive ◽  
Natural Polymers ◽  
Tissue Adhesives ◽  
Wound Closure Techniques ◽  
Accelerate Wound Healing ◽  
Tissue Surfaces ◽  
Crosslinking Reactions

To stop blood loss and accelerate wound healing, conventional wound closure techniques such as sutures and staples are currently used in the clinic. These tissue-piercing wound closure techniques have several disadvantages such as the potential for causing inflammation, infections, and scar formation. Surgical sealants and tissue adhesives can address some of the disadvantages of current sutures and staples. An ideal tissue adhesive will demonstrate strong interfacial adhesion and cohesive strength to wet tissue surfaces. Most reported studies rely on the liquid-to-solid transition of organic molecules by taking advantage of polymerization and crosslinking reactions for improving the cohesive strength of the adhesives. Crosslinking reactions triggered using light are commonly used for increasing tissue adhesive strength since the reactions can be controlled spatially and temporally, providing the on-demand curing of the adhesives with minimum misplacements. In this review, we describe the recent advances in the field of naturally derived tissue adhesives and sealants in which the adhesive and cohesive strengths are modulated using photochemical reactions.

scholarly journals Cyanoacrylate Tissue Adhesive as a Membrane in Socket Preservation: In Vitro Cytotoxicity and Clinical Evaluation

2020 ◽  
Author(s):  
Gerardo Mendoza Azpur ◽  
Junior ortiz ◽  
Erick Valdivia ◽  
Gabriela de Souza Balbinot ◽  
Fabricio Mezzomo Collares ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Evaluation ◽  
Tissue Adhesive ◽  
Gingival Tissue ◽  
Collagen Membrane ◽  
Socket Preservation ◽  
Post Surgery ◽  
Early Wound

Abstract Background: Cyanoacrylate-based adhesives provide immediate hemostasis when applied; this is attributed to their ability to form a mechanical barrier in the surgical site, favoring the coagulation process and allowing control of bleeding. The purpose of the present study was to demonstrate the in vitro effect of cyanoacrylate-based tissue adhesive and the clinical evaluation of wound healing of freshly extracted sockets with adhesives applied on an exposed collagen membrane, for preservation of the alveolar ridge. Methods: Cytotoxicity was evaluated with sulphoradamine B assay with primary fibroblasts from gingival tissue. The in vivo analysis was carried out in 10 patients needing extraction of single-rooted teeth, who met the inclusion and exclusion criteria and signed the term of free and informed consent. Alveolar preservation was carried out with a mineralized cortical allograft bone substitute and a resorbable collagen membrane that was intentionally left exposed. On the exposed membrane, the Periacryl® 90 HV was applied as a barrier. The biocompatibility of the adhesive was assessed by the Early-Wound Healing Index (EHI) and Early Wound Healing Score (EHS), of perialveolar tissues at time intervals of 12, 30- and 60-days post-surgery. Results: Reduced cell viability was observed for Periacryl® 90 HV when compared with cells without adhesive treatments. No postoperative complications were observed after the application of Periacryl® 90 HV on perialveolar tissues. Conclusion: The use of the Periacryl® 90 HV cyanoacrylate-based tissue adhesive resulted in reduced fibroblast viability in vitro, and adequate results of wound closure in the clinical evaluation of EHI and EHS scores.

scholarly journals Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

2021 ◽  
Vol 9 ◽  
Author(s):  
Yuhang Xing ◽  
Xueqin Qing ◽  
Hao Xia ◽  
Shiqi Hao ◽  
Haofang Zhu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Sodium Alginate ◽  
Biomedical Applications ◽  
Wound Closure ◽  
Tissue Adhesive ◽  
Uniform Structure ◽  
Tissue Adhesives ◽  
Promising Candidate ◽  
Injectable Hydrogel ◽  
Excellent Adhesion

To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.

scholarly journals Humic Acid Enhances Wound Healing in the Rat Palate

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Metin Çalışır ◽  
Aysun Akpınar ◽  
Ahmet Cemil Talmaç ◽  
Aysan Lektemur Alpan ◽  
Ömer Fahrettin Göze
Keyword(s):  
Wound Healing ◽  
Humic Acid ◽  
Acid Treatment ◽  
Wound Closure ◽  
Enhanced Recovery ◽  
Antibacterial Properties ◽  
Current Treatment ◽  
Chlorhexidine Gluconate ◽  
Saline Control ◽  
Rat Study

Introduction. Humic acid was previously shown to enhance cutaneous wound healing and show antibacterial properties; however, it has not been used for wound healing in the oral cavity. Thus, the goal of this study was the evaluation of the effect of the humic acid on the healing of excisional wounds in an experimental rat study. Materials and Methods. A circular wound on mid-palatal surfaces was made on a total of 77 Wistar rats by using a 3-mm biopsy punch under anesthesia. The animals were divided into 4 groups as baseline, saline control (0.09%), chlorhexidine gluconate (0.05%), and humic acid (80 mg/kg) and were treated with these materials for 7 days. Results. The rats were observed for 3 weeks in order to track the wound closure rates. Both humic acid treatment and chlorhexidine gluconate treatment resulted in statistically significant enhanced rate of wound closure compared to the saline control on both the 1st and 2nd weeks of treatment. Humic acid treatment for the wounds in the palate resulted in enhanced recovery compared to not only saline control but also chlorhexidine gluconate treatment. Conclusion. In this study, humic acid was shown to enhance healing of oral wounds for the first time in the literature. These findings indicate that humic acid can be used as an alternative to current treatment methods for oral wounds.

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