scholarly journals Role of Nanomedicine in Management and Prevention of COVID-19

2020 ◽  
Vol 2 ◽  
Author(s):  
Jitendra N. Wankar ◽  
Vivek K. Chaturvedi ◽  
Chandrashekhar Bohara ◽  
Mohan P. Singh ◽  
Raghvendra A. Bohara
Keyword(s):  
Side Effects ◽  
Severe Acute Respiratory Syndrome ◽  
Disease Outbreak ◽  
Target Site ◽  
Inorganic Materials ◽  
Pivotal Role ◽  
The World ◽  
Insight Into

COVID-19, or the Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic. At the time of writing this (July 28, 2020), more than 17 million people have become affected and 0.7 million people have died across the world. Remdesivir has shown glimpses of insight into how to fight the virus, but as of yet remain far from victory. Nanotechnology has proven its role in medicine to deliver the drug at the target site with minimal side effects, particularly in the anticancer domain. Most specifically, a range of nanotechnology-based products, such as nanosilver, are currently on the market because they have demonstrated the potential to combat viruses. This article provides an overview of the role of nanomedicine, including polymeric and inorganic materials, and its future capabilities in the management of the disease outbreak. Taking all this into account, an attempt has been made to educate readers in the simplest way of the role of nanomedicine, which can play a pivotal role in the management of diseases.

On Metaphysics and the Political: A Polemics of Reading Baudelaire in the 1930s

2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto
Keyword(s):  
Twentieth Century ◽  
Political Crisis ◽  
The Political ◽  
Modern Poetry ◽  
Progressive Politics ◽  
The World ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

Don Quixote, Part I (1605)

2021 ◽  
pp. 86-117
Author(s):  
Edwin Williamson
Keyword(s):  
Don Quixote ◽  
Cultural Significance ◽  
Second Best ◽  
La Mancha ◽  
The World ◽  
Insight Into

When it first appeared in 1605, Cervantes’s great novel Don Quixote de la Mancha became an international sensation. This chapter follows the chronology of the plot in a critical manner providing the reader with important insight into why Don Quixote has become the second best-selling book of all time. Including the famous scenes of the windmill, the liquidation of Don Quixote’s library, the funeral of Grisóstomo and redemption of Marcela, Ginés de Pasamonte and the galley slaves, El curioso impertinente, the famous tale of Cardenio the star-crossed lover, and a commentary on the role of drama and novels of chivalry in society, Don Quixote, Part One sets the hero and his trusty country squire against the world at large. This chapter explores its deep cultural significance and answers the question of whether or not it is merely a ‘funny book’.

scholarly journals Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies

2020 ◽  
Vol 11 ◽  
Author(s):  
Lihui Chen ◽  
Jie Li ◽  
Wu Zhu ◽  
Yehong Kuang ◽  
Tao Liu ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Therapeutic Strategies ◽  
Intestinal Microbiome ◽  
Core Microbiome ◽  
The Core ◽  
The World ◽  
Novel Therapeutic Strategies ◽  
Insight Into ◽  
Gaining Insight

Psoriasis affects the health of myriad populations around the world. The pathogenesis is multifactorial, and the exact driving factor remains unclear. This condition arises from the interaction between hyperproliferative keratinocytes and infiltrating immune cells, with poor prognosis and high recurrence. Better clinical treatments remain to be explored. There is much evidence that alterations in the skin and intestinal microbiome play an important role in the pathogenesis of psoriasis, and restoration of the microbiome is a promising preventive and therapeutic strategy for psoriasis. Herein, we have reviewed recent studies on the psoriasis-related microbiome in an attempt to confidently identify the “core” microbiome of psoriasis patients, understand the role of microbiome in the pathogenesis of psoriasis, and explore new therapeutic strategies for psoriasis through microbial intervention.

scholarly journals SPIKE PROTEIN AND ITS PROTEASES ROLE IN SARS-COV-2 PATHOGENICITY AND TREATMENT; A REVIEW

2021 ◽  
Vol 64 (1) ◽  
Author(s):  
Fateme Tavakoli Far ◽  
◽  
Ehsan Amiri-Ardekani ◽  
Keyword(s):  
Blood Pressure ◽  
Severe Acute Respiratory Syndrome ◽  
Small Molecules ◽  
Cathepsin B ◽  
Host Cells ◽  
Spike Protein ◽  
Pressure Regulation ◽  
Common Receptor ◽  
The World

Since December 2019, a novel beta coronavirus has spread around the world. This virus can cause severe acute respiratory syndrome (SARS). In this study, we reviewed proteases of SARS-CoV-2 based on related articles published in journals indexed by Scopus, PubMed, and Google Scholar from December 2019 to April 2020. Based on this study, we can claim that this coronavirus has about 76% genotype similarity to SARS coronavirus (SARS-CoV). Also, similarities between these two viruses have been found in the mechanism of entry into host cells and pathogenicity. ACE 2, the angiotensin convertase enzyme 2, plays a role in the Renin-Angiotensin-Aldosterone system (RAAS) and blood pressure regulation. Some mechanisms have been reported for the role of ACE 2 in the pathogenicity of SARS-CoV-2. For example, the interaction between the ACE 2 receptor and spike protein mediated by TMPRSS2, Cathepsin B/L, and other enzymes is responsible for the entry of the virus into human cells and pathogenicity. Some host cell endosomal enzymes are necessary to cleavage coronavirus spike protein and cause binding to their common receptor. So, we conclude that molecules like antibodies or small molecules like ACE 2 antagonists and soluble ACE 2 can be used as a good therapeutic candidate to prevent SARS-CoV-2.

Social Media Use Among Olympians and Sport Journalists in Hungary

2020 ◽  
Vol 13 (2) ◽  
pp. 181-199
Author(s):  
Agnes Kovacs ◽  
Tamas Doczi ◽  
Dunja Antunovic
Keyword(s):  
Social Media ◽  
Media Use ◽  
Social Media Use ◽  
The World ◽  
Social Media Platforms ◽  
The Media ◽  
Hungarian Case ◽  
The Relationship ◽  
Insight Into

The Olympic Games are among the most followed events in the world, so athletes who participate there are exceptionally interesting for the media. This research investigated Olympians’ social media use, sport journalists’ attitudes about Olympians’ social media use, and the role of social media in the relationship between Olympians and sport journalists in Hungary. The findings suggest that most Hungarian Olympians do not think that being on social media is an exceptionally key issue in their life, and a significant portion of them do not have public social media pages. However, sport journalists would like to see more information about athletes on social media platforms. The Hungarian case offers not only a general understanding of the athlete–journalist relationship, and the role of social media in it, but also insight into the specific features of the phenomenon in a state-supported, hybrid sport economy.

scholarly journals Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

Viruses ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 244 ◽  
Author(s):  
Jiabao Xu ◽  
Shizhe Zhao ◽  
Tieshan Teng ◽  
Abualgasim Elgaili Abdalla ◽  
Wan Zhu ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract Infections ◽  
Disease Outbreak ◽  
Respiratory Epithelium ◽  
Global Health Security ◽  
Health Security ◽  
The World ◽  
Similarities And Differences ◽  
Human Coronaviruses ◽  
Tract Infections

After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as “coronavirus disease 2019” (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.

Role of Forensic Nurses in the mortuary and postmortem examination

2020 ◽  
Vol 6 (01) ◽  
Author(s):  
RK. Gorea
Keyword(s):  
Developing Countries ◽  
Developed Countries ◽  
Postmortem Examination ◽  
Pivotal Role ◽  
Forensic Nursing ◽  
Nursing Science ◽  
The World ◽  
Fast Pace ◽  
The Developed Countries

Forensic nursing science is a developing at a fast pace in the developed countries of the world and the forensic nurses have gained valuable roles in the different departments. Mortuary services are often in a state of neglect in the developing countries especially the postmortem examination. Mainly this is due to lack of assistance to forensic physicians by educated and trained professionals. Forensic nurses can do a variety of roles to improve the functioning of the mortuaries. Role of forensic nurses in the postmortem examination and upkeep of the mortuaries is essential and it is emphasized that forensic nurses can play a very pivotal role in the functioning of the mortuaries.

scholarly journals An improved structural model of the human iron exporter ferroportin. Insight into the role of pathogenic mutations in hereditary hemochromatosis type 4

2017 ◽  
Vol 13 (4) ◽  
Author(s):  
Valentina Tortosa ◽  
Maria Carmela Bonaccorsi di Patti ◽  
Valentina Brandi ◽  
Giovanni Musci ◽  
Fabio Polticelli
Keyword(s):  
Membrane Protein ◽  
Crystal Structures ◽  
Iron Homeostasis ◽  
Structural Model ◽  
Hereditary Hemochromatosis ◽  
Structural Models ◽  
Pivotal Role ◽  
Cellular Iron ◽  
Insight Into

AbstractFerroportin (Fpn) is a membrane protein representing the major cellular iron exporter, essential for metal translocation from cells into plasma. Despite its pivotal role in human iron homeostasis, many questions on Fpn structure and biology remain unanswered. In this work, we present two novel and more reliable structural models of human Fpn (hFpn; inward-facing and outward-facing conformations) obtained using as templates the recently solved crystal structures of a bacterial homologue of hFpn,

From Royal Prayer Books to Common Prayers: Religious Practices in Late Medieval and Early Modern Poland

2006 ◽  
Vol 42 ◽  
pp. 180-188
Author(s):  
Urszula Borkowska Osu
Keyword(s):  
Early Modern ◽  
Christian Education ◽  
Religious Practice ◽  
Religious Practices ◽  
Royal Family ◽  
Liturgical Year ◽  
The World ◽  
Prayer Books ◽  
Insight Into

The Union between Poland and Lithuania, whose foundations were laid in 1386 with the baptism of Jagiello, the pagan grand duke of Lithuania, and his marriage to Queen Jadwiga (Hedwig), daughter of the last king of Poland, marked the beginning of a systematic Christianization to which the pagan Lithuanians offered remarkably little resistance. Recent research on religious practice under the ruling Jagiellonian dynasty in Poland and Lithuania (1386–1572) shows that royal piety was often designed to elicit participation at a popular level, cementing both the diffusion of Christian involvement across the newly unified kingdom, and in turn the role of the royal family at its centre. Surviving royal accounts and prayer books can offer a privileged insight into the personal religion of the monarchs and their relatives. These accounts, although only partially extant, constitute an objective source by which religious practices may be understood. Created for bureaucratic reasons, to keep order in the Treasurer’s Chancery, rather than to present the king as pious, they detail expenses for masses and other opera pia of the king and his family, recording the rhythm of royal religious practices – for the day, the week and the whole liturgical year. The accounts also provide evidence of sacramental practices and royal almsgiving. Pious literature composed at the behest of the Jagiellons, combined with extant pedagogical treatises and didactic sermons delivered in the presence of the monarch, is particularly valuable in admitting us into the world of royal Christian education.

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