Don Quixote, Part I (1605)

Author(s):  
Edwin Williamson

When it first appeared in 1605, Cervantes’s great novel Don Quixote de la Mancha became an international sensation. This chapter follows the chronology of the plot in a critical manner providing the reader with important insight into why Don Quixote has become the second best-selling book of all time. Including the famous scenes of the windmill, the liquidation of Don Quixote’s library, the funeral of Grisóstomo and redemption of Marcela, Ginés de Pasamonte and the galley slaves, El curioso impertinente, the famous tale of Cardenio the star-crossed lover, and a commentary on the role of drama and novels of chivalry in society, Don Quixote, Part One sets the hero and his trusty country squire against the world at large. This chapter explores its deep cultural significance and answers the question of whether or not it is merely a ‘funny book’.

2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.


2020 ◽  
Vol 11 ◽  
Author(s):  
Lihui Chen ◽  
Jie Li ◽  
Wu Zhu ◽  
Yehong Kuang ◽  
Tao Liu ◽  
...  

Psoriasis affects the health of myriad populations around the world. The pathogenesis is multifactorial, and the exact driving factor remains unclear. This condition arises from the interaction between hyperproliferative keratinocytes and infiltrating immune cells, with poor prognosis and high recurrence. Better clinical treatments remain to be explored. There is much evidence that alterations in the skin and intestinal microbiome play an important role in the pathogenesis of psoriasis, and restoration of the microbiome is a promising preventive and therapeutic strategy for psoriasis. Herein, we have reviewed recent studies on the psoriasis-related microbiome in an attempt to confidently identify the “core” microbiome of psoriasis patients, understand the role of microbiome in the pathogenesis of psoriasis, and explore new therapeutic strategies for psoriasis through microbial intervention.


2020 ◽  
Vol 13 (2) ◽  
pp. 181-199
Author(s):  
Agnes Kovacs ◽  
Tamas Doczi ◽  
Dunja Antunovic

The Olympic Games are among the most followed events in the world, so athletes who participate there are exceptionally interesting for the media. This research investigated Olympians’ social media use, sport journalists’ attitudes about Olympians’ social media use, and the role of social media in the relationship between Olympians and sport journalists in Hungary. The findings suggest that most Hungarian Olympians do not think that being on social media is an exceptionally key issue in their life, and a significant portion of them do not have public social media pages. However, sport journalists would like to see more information about athletes on social media platforms. The Hungarian case offers not only a general understanding of the athlete–journalist relationship, and the role of social media in it, but also insight into the specific features of the phenomenon in a state-supported, hybrid sport economy.


2006 ◽  
Vol 42 ◽  
pp. 180-188
Author(s):  
Urszula Borkowska Osu

The Union between Poland and Lithuania, whose foundations were laid in 1386 with the baptism of Jagiello, the pagan grand duke of Lithuania, and his marriage to Queen Jadwiga (Hedwig), daughter of the last king of Poland, marked the beginning of a systematic Christianization to which the pagan Lithuanians offered remarkably little resistance. Recent research on religious practice under the ruling Jagiellonian dynasty in Poland and Lithuania (1386–1572) shows that royal piety was often designed to elicit participation at a popular level, cementing both the diffusion of Christian involvement across the newly unified kingdom, and in turn the role of the royal family at its centre. Surviving royal accounts and prayer books can offer a privileged insight into the personal religion of the monarchs and their relatives. These accounts, although only partially extant, constitute an objective source by which religious practices may be understood. Created for bureaucratic reasons, to keep order in the Treasurer’s Chancery, rather than to present the king as pious, they detail expenses for masses and other opera pia of the king and his family, recording the rhythm of royal religious practices – for the day, the week and the whole liturgical year. The accounts also provide evidence of sacramental practices and royal almsgiving. Pious literature composed at the behest of the Jagiellons, combined with extant pedagogical treatises and didactic sermons delivered in the presence of the monarch, is particularly valuable in admitting us into the world of royal Christian education.


Author(s):  
SWAGATIKA PRIYADARSINI ◽  
ROHIT SINGH ◽  
ARUN SOMAGOND ◽  
PUJA MECH

Coronavirus disease is the current cause of global concern. The massive outbreak of COVID-19 has led the World Health Organization (WHO) to declare this as a pandemic situation. The Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCoV-2) is responsible for COVID-19 leading to acute respiratory distress and substantial mortality in humans. However, the first laboratory confirmation of SARS-CoV-2 in a pet dog in Hong Kong has shown the possibility of human-to-animal transmission (zooanthroponotic) of the virus. Thereafter, many animals including cat, tiger, lion and mink have also been reported to acquire the virus in several countries. In this situation the role of veterinarian assumes important in treating the animals, helping in food security, disease diagnosis, surveillance and boosting the economy of livestock stakeholders at the grassroot level. In the absence of any selective vaccine or drug against SARS-CoV-2, the world is anticipated to triumph over this pandemic with collaborative, multisectoral, and transdisciplinary approach linking human, animal and environmental health. This article gives an insight into the confirmed SARS-CoV-2 outbreaks in animals, including the factors behind the shuffling of the virus among variety of species and also emphasizes on the role of veterinarian in managing and safeguarding public health so as to pave the way for adopting one health approach in order to conserve biodiversity.


2021 ◽  
Vol 22 (21) ◽  
pp. 12024
Author(s):  
Chiara Stassi ◽  
Cristina Mondello ◽  
Gennaro Baldino ◽  
Luigi Cardia ◽  
Alessio Asmundo ◽  
...  

On 11 March 2020, the World Health Organization (WHO) declared a pandemic due to the spread of COVID-19 from Wuhan, China, causing high mortality rates all over the world. The related disease, which mainly affects the lungs, is responsible for the onset of Diffuse Alveolar Damage (DAD) and a hypercoagulability state, frequently leading to Severe Acute Respiratory Syndrome (SARS) and multiorgan failure, particularly in old and severe-critically ill patients. In order to find effective therapeutic strategies, many efforts have been made aiming to shed light on the pathophysiology of COVID-19 disease. Moreover, following the late advent of vaccination campaigns, the need for the comprehension of the pathophysiology of the fatal, although rare, thrombotic adverse events has become mandatory as well. The achievement of such purposes needs a multidisciplinary approach, depending on a correct interpretation of clinical, biochemical, biomolecular, and forensic findings. In this scenario, autopsies have helped in defining, on both gross and histologic examinations, the main changes to which the affected organs undergo and the role in assessing whether a patient is dead “from” or “with” COVID-19, not to mention whether the existence of a causal link exists between vaccination and thrombotic adverse events. In the present work, we explored the role of postmortem immunohistochemistry, and the increasingly used ancillary technique, in helping to understand the mechanism underlying the pathophysiology of both COVID-19 disease and COVID-19 vaccine-related adverse and rare effects.


Author(s):  
Rowan McLelland

This chapter discusses international ballet competitions through exploring their contributions to ballet as a transnational practice. It provides an ethnographic account, specifically focused on the multilayered significance of competing for aspiring dancers in the People’s Republic of China, in addition to assessing the role of competitions in the broader institution of ballet in China. The chapter investigates the value found in engaging with ballet competitions in terms of physical, social, economic, and political capital. It explores how value operates differently for individual competitors, dance teachers, training institutions, and even nations, both within China and in the rest of the world, to indicate the significance of competitions as a contributing factor to China’s increasing status in ballet more widely.


Author(s):  
Süheyla Bozkurt

The aim is to open the discussion of the concept of education and school that emerged as a result of the changes in information technologies and to provide insight into the future educational institutions. Firstly, the effects of changes in the world on educational institutions were discussed. The skills needed by the world were introduced and finally the 21st century Web 1.0, 2.0, 3.0, and 4.0 technologies, which are information sharing methods that enable data sharing over the internet. In the conclusion part, a school structure where principles such as personalized ways and methods of access to information, development of creativity, acquisition of necessary methods for reasoning, integration of information with systematic attitude is proposed. For the schools of the future, it has been concluded that the elements of education such as classrooms, technique, methods, tools, and materials, and the role of the teacher should be reconsidered, and the school should be designed in a way that individuals can establish their own knowledge sphere within the boundaries of the school buildings.


2020 ◽  
Vol 2 ◽  
Author(s):  
Jitendra N. Wankar ◽  
Vivek K. Chaturvedi ◽  
Chandrashekhar Bohara ◽  
Mohan P. Singh ◽  
Raghvendra A. Bohara

COVID-19, or the Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic. At the time of writing this (July 28, 2020), more than 17 million people have become affected and 0.7 million people have died across the world. Remdesivir has shown glimpses of insight into how to fight the virus, but as of yet remain far from victory. Nanotechnology has proven its role in medicine to deliver the drug at the target site with minimal side effects, particularly in the anticancer domain. Most specifically, a range of nanotechnology-based products, such as nanosilver, are currently on the market because they have demonstrated the potential to combat viruses. This article provides an overview of the role of nanomedicine, including polymeric and inorganic materials, and its future capabilities in the management of the disease outbreak. Taking all this into account, an attempt has been made to educate readers in the simplest way of the role of nanomedicine, which can play a pivotal role in the management of diseases.


2021 ◽  
Vol 271 ◽  
pp. 03032
Author(s):  
Jingwen Zhu

Asthma is one of the most common chronic respiratory diseases in the world. Although treatments and medications that can control the symptoms of asthma are available, no cure has been developed. Ion channels are transmembrane proteins that facilitate the diffusion of ions across membranes. In the airways, ion channels are involved in signalling between cells and regulation of intracellular ion concentration, which may lead to the activation of airway cells, immune cells, and neurons. This review mainly focuses on discoveries made so far in animal models and clinical trials regarding ion channels and asthma and gives some insight into developing treatments targeting ion channels.


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