scholarly journals Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 37
Author(s):  
Tomasz Urbanowicz ◽  
Anna Olasińska-Wiśniewska ◽  
Michał Michalak ◽  
Michał Rodzki ◽  
Anna Witkowska ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Immunosuppressive Therapy ◽  
Heart Transplant ◽  
Whole Blood ◽  
Blood Count ◽  
Neutrophil To Lymphocyte Ratio ◽  
Term Survival ◽  
Lymphocyte Ratio ◽  
Spearman's Rho ◽  
Spearman’S Rho

(1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory reactions activation and may play a clinical role as a predictive marker in oncological and cardiovascular diseases. The aim of the study was to find simple hematologic indices available from whole blood count to help in immunosuppressive therapy monitoring. (2) Methods: Thirty patients (23 men and 7 women) with a mean age of 43 +/− 13 years who had undergone orthotopic heart transplantation were enrolled into the study. The blood samples for whole blood count and Tacrolimus level were collected during outpatient visits in heart transplant recipients every two months for 18 months after first year post transplantation. (3) Results: There was a significant correlation between Tacrolimus overdose (>15 ng/mL) and NLR (Spearman’s rho 0.99, p < 0,001) and mean platelet volume (Spearman’s rho 0.989, p < 0.001). The ROC analysis for NLR above 3.62 showed predictive properties for Tacrolimus overdose (over 15 ng/mL) (AUC =0.633, p = 0.008) with a sensitivity of 50% and specificity of 83.73%. (4) Conclusions: Our results suggest that NLR above 3.62 may be regarded as a simple indicator of tacrolimus overdose.

Correlation of Clinical Signs and Symptoms of Behçet’s Disease With Platelet to Lymphocyte Ratio (PLR) and Neutrophil to Lymphocyte Ratio (NLR)

2021 ◽  
Author(s):  
Soraya Shadmanfar ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Farhad Shahram ◽  
Maassoumeh Akhlaghi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Platelet To Lymphocyte Ratio ◽  
Behcet's Disease ◽  
Lymphocyte Ratio ◽  
Spearman's Rho ◽  
Spearman’S Rho

Abstract BackgroundBehçet’s disease (BD) is a chronic disorder that involves multiple organs and is pathologically considered as a form of vasculitis. The current study aims to assess the metric properties of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) in assessing BD disease activity.MethodsThree-hundred-nineteen patients with BD were enrolled in this cross-sectional study. Demographic and epidemiological data, including IBDDAM, time since the onset, and medication and manifestation history was recorded. Complete blood counts (CBC), NLR, and PLR were assessed by analyzing blood samples. On the last visit, patients were assessed for active manifestations of disease. IBDDAM and ocular IBDAAM scores were calculated for activity of disease in each patient.ResultsBoth PLR and NLR were higher in patients with active BD (Man-Whitney U test, P-value<0.05). Patients with active ocular manifestation had significantly higher NLR and PLR (Man-Whitney U test, P-value<0.05). These ratios, however, were not associated with other active BD manifestations. A value of NLR >2.58 had 46% sensitivity and 85% specificity for the diagnosis of active ocular manifestations (AUC: 0.690). NLR had a significant though weak positive correlation with IBDDAM (Spearman’s rho = 0.162; p-value <0.05) and ocular IBDDAM (Spearman’s rho = 0.159; p-value < 0.05). ConclusionActive Behçet’s presented with higher NLR and PLR ratios; however, there was only a modest correlation between NLR and BD activity (IBDDAM score). Also NLR and PLR have significant relationship with ocular features of BD patients.

scholarly journals Long-Term Outcomes and Risk Factors of Renal Failure Requiring Dialysis after Heart Transplantation: A Nationwide Cohort Study

2020 ◽  
Vol 9 (8) ◽  
pp. 2455 ◽  
Author(s):  
Tsai-Jung Wang ◽  
Ching-Heng Lin ◽  
Hao-Ji Wei ◽  
Ming-Ju Wu
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Renal Failure ◽  
Heart Transplantation ◽  
Renal Dysfunction ◽  
Heart Transplant ◽  
Kidney Injury ◽  
Dialysis Patients ◽  
Term Survival

Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk factors of dialysis were investigated. Patients who had undergone dialysis were stratified to early or late dialysis for subgroup analysis. The mean follow-up was five years, the incidence of dialysis was 28.4% (21% early dialysis and 7.4% late dialysis). The dialysis cohort had higher overall mortality compared with the non-dialysis cohort. The hazard ratios of mortality in patients with dialysis were 3.44 (95% confidence interval (CI), 2.73–4.33) for all dialysis patients, 3.58 (95% CI, 2.74–4.67) for early dialysis patients, and 3.27 (95% CI, 2.44–4.36; all p < 0.001) for late dialysis patients. Patients with diabetes mellitus, chronic kidney disease, acute kidney injury, and coronary artery disease were at higher risk of renal failure requiring dialysis. Cardiomyopathy, hepatitis B virus infection, and hyperlipidemia treated with statins were associated with a lower risk of renal dysfunction requiring early dialysis. The use of Sirolimus and Mycophenolate mofetil was associated with a lower incidence of late dialysis. Renal dysfunction requiring dialysis after heart transplantation is common in Taiwan. Early and late dialysis were both associated with an increased risk of mortality in heart transplant recipients.

scholarly journals Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of survival after heart transplantation

2017 ◽  
Vol 5 (1) ◽  
pp. 149-156 ◽  
Author(s):  
Ignacio M. Seropian ◽  
Francisco J. Romeo ◽  
Rodolfo Pizarro ◽  
Norberto O. Vulcano ◽  
Ricardo A. Posatini ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Relation between Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Cerebral Infarct Volume in patients with Ischemic Stroke.

2021 ◽  
Vol 5 (1) ◽  
pp. 769-772
Author(s):  
Avni Uygar Seyhan ◽  
Erdal Yilmaz ◽  
Semih Korkut
Keyword(s):  
Emergency Department ◽  
Ischemic Stroke ◽  
Retrospective Study ◽  
Stroke Volume ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Term Survival ◽  
Stroke Incidence ◽  
Lymphocyte Ratio ◽  
Emergency Doctors

Abstract :  Objectives: The activation of inflammatory processes in ischemic stroke might be important for the pathophysiological processes of ischemic stroke. The correlation between the Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR) and stroke volume is increasingly being recognized as a prognostic biomarker for patient outcome after an ischemic stroke incidence. This retrospective study aimed at determining if there is existed correlation between the NLR, PLR and stroke volume in patients presenting with ischemic stroke at the emergency department. The results will aid emergency doctors to gain an understanding on how to rapidly identify the most high-risk patients based on the NLR and taPLR obtained from routine blood tests permitting rapidly therapeutic interventions and better long-term survival outcomes for patients with ischemic strokes.  Methods: A retrospective study was performed between May 2016-2019. Patients 18 years and older of both genders presented to the emergency department with symptoms of ischemic stroke with time of onset of symptoms within the last 24 hours of whom complete blood count (CBC) tests were conducted and ischemic stroke was confirmed by Diffusion weighted Magnetic Resonance Imaging (DWI-MRI) were enrolled. NLR and PLR were calculated from CBC tests and ischemic stroke volume was measured in mm3 using Manual Segmentation Process. Results: A total of 489 patients were enrolled in this study of which 266 (54.5%) were male and 223 (45.6%) were female. It was observed a statistically significant correlation between the ischemic stroke volume and NLR while no significant correlation was observed between stroke volume and PLR. Conclusion: There is a significant weak positive relationship between NLR and ischemic stroke volume. NLR is significantly correlated with cerebral ischemic stroke volume and thus can be utilized as a guide by emergency doctors in the emergency department to predict the severity and the outcome of patients diagnosed with ischemic stroke.

scholarly journals New Marker for Suspected Open Globe Injury (Perforation or Penetration): Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio

2020 ◽  
pp. 31-36
Author(s):  
Kenan Yiğit ◽  
Reşat Duman ◽  
Rahmi Duman ◽  
Zubeyir Yozgat ◽  
Ersan Çetinkaya ◽  
...  
Keyword(s):  
Blood Count ◽  
Neutrophil To Lymphocyte Ratio ◽  
Open Globe Injury ◽  
Platelet To Lymphocyte Ratio ◽  
Orbital Trauma ◽  
Acute Period ◽  
Lymphocyte Ratio ◽  
Injury Group ◽  
Open Globe ◽  
Significant Difference

Purpose: To compare the strength of the relationship between the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio(PLR) results of patients with or without open globe injury (perforation and penetration) in the acute period of orbital trauma. Materials and Methods: Forty patients with open globe injuryand twenty-five patients without open globe injury in the acute period of orbital trauma were enrolled in this retrospective study. Complete blood count measurement results of all subjects were assessed. Results: There was a significant difference in neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio between orbital trauma with open globe injury group and without open globe injury group (p=0.001, p=0.006). Conclusion: Our results of the blood count measurements suggest that the NLR and PLR at first three hours may predict ocular perforation/penetration and the clinicians have to alert are a risk factor of open globe injury.

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