scholarly journals Predicting miRNA-Disease Associations by Incorporating Projections in Low-Dimensional Space and Local Topological Information

Genes ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 685 ◽  
Author(s):  
Xuan ◽  
Zhang ◽  
Zhang ◽  
Li ◽  
Zhao
Keyword(s):  
Dimensional Space ◽  
Characteristic Curve ◽  
Feature Space ◽  
Superior Performance ◽  
Topological Information ◽  
Heterogeneous Information ◽  
Feature Representations ◽  
Disease Associations ◽  
Precision Recall Curve ◽  
Low Dimensional

Predicting the potential microRNA (miRNA) candidates associated with a disease helps in exploring the mechanisms of disease development. Most recent approaches have utilized heterogeneous information about miRNAs and diseases, including miRNA similarities, disease similarities, and miRNA-disease associations. However, these methods do not utilize the projections of miRNAs and diseases in a low-dimensional space. Thus, it is necessary to develop a method that can utilize the effective information in the low-dimensional space to predict potential disease-related miRNA candidates. We proposed a method based on non-negative matrix factorization, named DMAPred, to predict potential miRNA-disease associations. DMAPred exploits the similarities and associations of diseases and miRNAs, and it integrates local topological information of the miRNA network. The likelihood that a miRNA is associated with a disease also depends on their projections in low-dimensional space. Therefore, we project miRNAs and diseases into low-dimensional feature space to yield their low-dimensional and dense feature representations. Moreover, the sparse characteristic of miRNA-disease associations was introduced to make our predictive model more credible. DMAPred achieved superior performance for 15 well-characterized diseases with AUCs (area under the receiver operating characteristic curve) ranging from 0.860 to 0.973 and AUPRs (area under the precision-recall curve) ranging from 0.118 to 0.761. In addition, case studies on breast, prostatic, and lung neoplasms demonstrated the ability of DMAPred to discover potential disease-related miRNAs.

scholarly journals Prediction of Disease-related microRNAs through Integrating Attributes of microRNA Nodes and Multiple Kinds of Connecting Edges

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3099 ◽  
Author(s):  
Xuan ◽  
Li ◽  
Zhang ◽  
Zhang ◽  
Song
Keyword(s):  
State Of The Art ◽  
Dimensional Space ◽  
Nonnegative Matrix ◽  
Superior Performance ◽  
Pancreatic Cancers ◽  
Node Attribute ◽  
Disease Associations ◽  
Node Attributes ◽  
Novel Method ◽  
Low Dimensional

Identifying disease-associated microRNAs (disease miRNAs) contributes to the understanding of disease pathogenesis. Most previous computational biology studies focused on multiple kinds of connecting edges of miRNAs and diseases, including miRNA–miRNA similarities, disease–disease similarities, and miRNA–disease associations. Few methods exploited the node attribute information related to miRNA family and cluster. The previous methods do not completely consider the sparsity of node attributes. Additionally, it is challenging to deeply integrate the node attributes of miRNAs and the similarities and associations related to miRNAs and diseases. In the present study, we propose a novel method, known as MDAPred, based on nonnegative matrix factorization to predict candidate disease miRNAs. MDAPred integrates the node attributes of miRNAs and the related similarities and associations of miRNAs and diseases. Since a miRNA is typically subordinate to a family or a cluster, the node attributes of miRNAs are sparse. Similarly, the data for miRNA and disease similarities are sparse. Projecting the miRNA and disease similarities and miRNA node attributes into a common low-dimensional space contributes to estimating miRNA-disease associations. Simultaneously, the possibility that a miRNA is associated with a disease depends on the miRNA’s neighbour information. Therefore, MDAPred deeply integrates projections of multiple kinds of connecting edges, projections of miRNAs node attributes, and neighbour information of miRNAs. The cross-validation results showed that MDAPred achieved superior performance compared to other state-of-the-art methods for predicting disease-miRNA associations. MDAPred can also retrieve more actual miRNA-disease associations at the top of prediction results, which is very important for biologists. Additionally, case studies of breast, lung, and pancreatic cancers further confirmed the ability of MDAPred to discover potential miRNA–disease associations.

scholarly journals Inferring the Disease-Associated miRNAs Based on Network Representation Learning and Convolutional Neural Networks

2019 ◽  
Vol 20 (15) ◽  
pp. 3648 ◽  
Author(s):  
Xuan ◽  
Sun ◽  
Wang ◽  
Zhang ◽  
Pan
Keyword(s):  
Neural Networks ◽  
Convolutional Neural Networks ◽  
Prediction Models ◽  
Prediction Method ◽  
Feature Space ◽  
Representation Learning ◽  
Superior Performance ◽  
Network Representation ◽  
Disease Associations ◽  
Low Dimensional

Identification of disease-associated miRNAs (disease miRNAs) are critical for understanding etiology and pathogenesis. Most previous methods focus on integrating similarities and associating information contained in heterogeneous miRNA-disease networks. However, these methods establish only shallow prediction models that fail to capture complex relationships among miRNA similarities, disease similarities, and miRNA-disease associations. We propose a prediction method on the basis of network representation learning and convolutional neural networks to predict disease miRNAs, called CNNMDA. CNNMDA deeply integrates the similarity information of miRNAs and diseases, miRNA-disease associations, and representations of miRNAs and diseases in low-dimensional feature space. The new framework based on deep learning was built to learn the original and global representation of a miRNA-disease pair. First, diverse biological premises about miRNAs and diseases were combined to construct the embedding layer in the left part of the framework, from a biological perspective. Second, the various connection edges in the miRNA-disease network, such as similarity and association connections, were dependent on each other. Therefore, it was necessary to learn the low-dimensional representations of the miRNA and disease nodes based on the entire network. The right part of the framework learnt the low-dimensional representation of each miRNA and disease node based on non-negative matrix factorization, and these representations were used to establish the corresponding embedding layer. Finally, the left and right embedding layers went through convolutional modules to deeply learn the complex and non-linear relationships among the similarities and associations between miRNAs and diseases. Experimental results based on cross validation indicated that CNNMDA yields superior performance compared to several state-of-the-art methods. Furthermore, case studies on lung, breast, and pancreatic neoplasms demonstrated the powerful ability of CNNMDA to discover potential disease miRNAs.

scholarly journals Prediction of Potential Drug–Disease Associations through Deep Integration of Diversity and Projections of Various Drug Features

2019 ◽  
Vol 20 (17) ◽  
pp. 4102 ◽  
Author(s):  
Ping Xuan ◽  
Yingying Song ◽  
Tiangang Zhang ◽  
Lan Jia
Keyword(s):  
Drug Target ◽  
Feature Space ◽  
Potential Candidate ◽  
Potential Drug ◽  
Related Data ◽  
Feature Representations ◽  
Disease Similarity ◽  
Disease Associations ◽  
Deep Integration ◽  
Low Dimensional

Identifying new indications for existing drugs may reduce costs and expedites drug development. Drug-related disease predictions typically combined heterogeneous drug-related and disease-related data to derive the associations between drugs and diseases, while recently developed approaches integrate multiple kinds of drug features, but fail to take the diversity implied by these features into account. We developed a method based on non-negative matrix factorization, DivePred, for predicting potential drug–disease associations. DivePred integrated disease similarity, drug–disease associations, and various drug features derived from drug chemical substructures, drug target protein domains, drug target annotations, and drug-related diseases. Diverse drug features reflect the characteristics of drugs from different perspectives, and utilizing the diversity of multiple kinds of features is critical for association prediction. The various drug features had higher dimensions and sparse characteristics, whereas DivePred projected high-dimensional drug features into the low-dimensional feature space to generate dense feature representations of drugs. Furthermore, DivePred’s optimization term enhanced diversity and reduced redundancy of multiple kinds of drug features. The neighbor information was exploited to infer the likelihood of drug–disease associations. Experiments indicated that DivePred was superior to several state-of-the-art methods for prediction drug-disease association. During the validation process, DivePred identified more drug-disease associations in the top part of prediction result than other methods, benefitting further biological validation. Case studies of acetaminophen, ciprofloxacin, doxorubicin, hydrocortisone, and ampicillin demonstrated that DivePred has the ability to discover potential candidate disease indications for drugs.

scholarly journals Seq-SymRF: a random forest model predicts potential miRNA-disease associations based on information of sequences and clinical symptoms

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jinlong Li ◽  
Xingyu Chen ◽  
Qixing Huang ◽  
Yang Wang ◽  
Yun Xie ◽  
...  
Keyword(s):  
Random Forest ◽  
Breast Neoplasms ◽  
Clinical Symptoms ◽  
Characteristic Curve ◽  
Vital Role ◽  
Sequence Information ◽  
Source Codes ◽  
Drug Identification ◽  
Disease Associations ◽  
Precision Recall Curve

Abstract Increasing evidence indicates that miRNAs play a vital role in biological processes and are closely related to various human diseases. Research on miRNA-disease associations is helpful not only for disease prevention, diagnosis and treatment, but also for new drug identification and lead compound discovery. A novel sequence- and symptom-based random forest algorithm model (Seq-SymRF) was developed to identify potential associations between miRNA and disease. Features derived from sequence information and clinical symptoms were utilized to characterize miRNA and disease, respectively. Moreover, the clustering method by calculating the Euclidean distance was adopted to construct reliable negative samples. Based on the fivefold cross-validation, Seq-SymRF achieved the accuracy of 98.00%, specificity of 99.43%, sensitivity of 96.58%, precision of 99.40% and Matthews correlation coefficient of 0.9604, respectively. The areas under the receiver operating characteristic curve and precision recall curve were 0.9967 and 0.9975, respectively. Additionally, case studies were implemented with leukemia, breast neoplasms and hsa-mir-21. Most of the top-25 predicted disease-related miRNAs (19/25 for leukemia; 20/25 for breast neoplasms) and 15 of top-25 predicted miRNA-related diseases were verified by literature and dbDEMC database. It is anticipated that Seq-SymRF could be regarded as a powerful high-throughput virtual screening tool for drug research and development. All source codes can be downloaded from https://github.com/LeeKamlong/Seq-SymRF.

scholarly journals Graph Convolutional Network and Convolutional Neural Network Based Method for Predicting lncRNA-Disease Associations

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1012 ◽  
Author(s):  
Xuan ◽  
Pan ◽  
Zhang ◽  
Liu ◽  
Sun
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Heterogeneous Network ◽  
Heterogeneous Data ◽  
Superior Performance ◽  
Convolutional Network ◽  
Topological Information ◽  
Disease Pair ◽  
Disease Associations ◽  
The Right

Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate their pertinent heterogeneous data. However, they failed to deeply integrate topological information of heterogeneous network comprising lncRNAs, diseases, and miRNAs. We proposed a novel method based on the graph convolutional network and convolutional neural network, referred to as GCNLDA, to infer disease-related lncRNA candidates. The heterogeneous network containing the lncRNA, disease, and miRNA nodes, is constructed firstly. The embedding matrix of a lncRNA-disease node pair was constructed according to various biological premises about lncRNAs, diseases, and miRNAs. A new framework based on a graph convolutional network and a convolutional neural network was developed to learn network and local representations of the lncRNA-disease pair. On the left side of the framework, the autoencoder based on graph convolution deeply integrated topological information within the heterogeneous lncRNA-disease-miRNA network. Moreover, as different node features have discriminative contributions to the association prediction, an attention mechanism at node feature level is constructed. The left side learnt the network representation of the lncRNA-disease pair. The convolutional neural networks on the right side of the framework learnt the local representation of the lncRNA-disease pair by focusing on the similarities, associations, and interactions that are only related to the pair. Compared to several state-of-the-art prediction methods, GCNLDA had superior performance. Case studies on stomach cancer, osteosarcoma, and lung cancer confirmed that GCNLDA effectively discovers the potential lncRNA-disease associations.

Community detection in complex network by network embedding and density clustering

2021 ◽  
pp. 1-12
Author(s):  
JinFang Sheng ◽  
Huaiyu Zuo ◽  
Bin Wang ◽  
Qiong Li
Keyword(s):  
Complex Network ◽  
Community Detection ◽  
Dimensional Space ◽  
Detection Algorithm ◽  
Superior Performance ◽  
Network Embedding ◽  
Detection Algorithms ◽  
Density Clustering ◽  
Community Detection Algorithm ◽  
Low Dimensional

 In a complex network system, the structure of the network is an extremely important element for the analysis of the system, and the study of community detection algorithms is key to exploring the structure of the complex network. Traditional community detection algorithms would represent the network using an adjacency matrix based on observations, which may contain redundant information or noise that interferes with the detection results. In this paper, we propose a community detection algorithm based on density clustering. In order to improve the performance of density clustering, we consider an algorithmic framework for learning the continuous representation of network nodes in a low-dimensional space. The network structure is effectively preserved through network embedding, and density clustering is applied in the embedded low-dimensional space to compute the similarity of nodes in the network, which in turn reveals the implied structure in a given network. Experiments show that the algorithm has superior performance compared to other advanced community detection algorithms for real-world networks in multiple domains as well as synthetic networks, especially when the network data chaos is high.

scholarly journals NEDD: a network embedding based method for predicting drug-disease associations

2020 ◽  
Vol 21 (S13) ◽  
Author(s):  
Renyi Zhou ◽  
Zhangli Lu ◽  
Huimin Luo ◽  
Ju Xiang ◽  
Min Zeng ◽  
...  
Keyword(s):  
Drug Repositioning ◽  
Computational Method ◽  
Heterogeneous Information ◽  
Gold Standard Dataset ◽  
Disease Similarity ◽  
Disease Associations ◽  
Meta Path ◽  
Approved Drugs ◽  
Low Dimensional ◽  
Novel Associations

Abstract Background Drug discovery is known for the large amount of money and time it consumes and the high risk it takes. Drug repositioning has, therefore, become a popular approach to save time and cost by finding novel indications for approved drugs. In order to distinguish these novel indications accurately in a great many of latent associations between drugs and diseases, it is necessary to exploit abundant heterogeneous information about drugs and diseases. Results In this article, we propose a meta-path-based computational method called NEDD to predict novel associations between drugs and diseases using heterogeneous information. First, we construct a heterogeneous network as an undirected graph by integrating drug-drug similarity, disease-disease similarity, and known drug-disease associations. NEDD uses meta paths of different lengths to explicitly capture the indirect relationships, or high order proximity, within drugs and diseases, by which the low dimensional representation vectors of drugs and diseases are obtained. NEDD then uses a random forest classifier to predict novel associations between drugs and diseases. Conclusions The experiments on a gold standard dataset which contains 1933 validated drug–disease associations show that NEDD produces superior prediction results compared with the state-of-the-art approaches.

scholarly journals Relation Structure-Aware Heterogeneous Information Network Embedding

2019 ◽  
Vol 33 ◽  
pp. 4456-4463 ◽  
Author(s):  
Yuanfu Lu ◽  
Chuan Shi ◽  
Linmei Hu ◽  
Zhiyuan Liu
Keyword(s):  
Real World ◽  
Dimensional Space ◽  
Structural Characteristics ◽  
Information Network ◽  
Network Embedding ◽  
Heterogeneous Information Network ◽  
Heterogeneous Information ◽  
Real World Datasets ◽  
Low Dimensional ◽  
Embedding Methods

Heterogeneous information network (HIN) embedding aims to embed multiple types of nodes into a low-dimensional space. Although most existing HIN embedding methods consider heterogeneous relations in HINs, they usually employ one single model for all relations without distinction, which inevitably restricts the capability of network embedding. In this paper, we take the structural characteristics of heterogeneous relations into consideration and propose a novel Relation structure-aware Heterogeneous Information Network Embedding model (RHINE). By exploring the real-world networks with thorough mathematical analysis, we present two structure-related measures which can consistently distinguish heterogeneous relations into two categories: Affiliation Relations (ARs) and Interaction Relations (IRs). To respect the distinctive characteristics of relations, in our RHINE, we propose different models specifically tailored to handle ARs and IRs, which can better capture the structures and semantics of the networks. At last, we combine and optimize these models in a unified and elegant manner. Extensive experiments on three real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods in various tasks, including node clustering, link prediction, and node classification.

A graph auto-encoder model for miRNA-disease associations prediction

2020 ◽  
Author(s):  
Zhengwei Li ◽  
Jiashu Li ◽  
Ru Nie ◽  
Zhu-Hong You ◽  
Wenzheng Bao
Keyword(s):  
Neural Networks ◽  
Clinical Medicine ◽  
Area Under The Curve ◽  
Heterogeneous Information ◽  
Source Codes ◽  
Differentially Expressed Mirnas ◽  
Disease Associations ◽  
Graph Neural Networks ◽  
New Biomarkers ◽  
Low Dimensional

Abstract Emerging evidence indicates that the abnormal expression of miRNAs involves in the evolution and progression of various human complex diseases. Identifying disease-related miRNAs as new biomarkers can promote the development of disease pathology and clinical medicine. However, designing biological experiments to validate disease-related miRNAs is usually time-consuming and expensive. Therefore, it is urgent to design effective computational methods for predicting potential miRNA-disease associations. Inspired by the great progress of graph neural networks in link prediction, we propose a novel graph auto-encoder model, named GAEMDA, to identify the potential miRNA-disease associations in an end-to-end manner. More specifically, the GAEMDA model applies a graph neural networks-based encoder, which contains aggregator function and multi-layer perceptron for aggregating nodes’ neighborhood information, to generate the low-dimensional embeddings of miRNA and disease nodes and realize the effective fusion of heterogeneous information. Then, the embeddings of miRNA and disease nodes are fed into a bilinear decoder to identify the potential links between miRNA and disease nodes. The experimental results indicate that GAEMDA achieves the average area under the curve of $93.56\pm 0.44\%$ under 5-fold cross-validation. Besides, we further carried out case studies on colon neoplasms, esophageal neoplasms and kidney neoplasms. As a result, 48 of the top 50 predicted miRNAs associated with these diseases are confirmed by the database of differentially expressed miRNAs in human cancers and microRNA deregulation in human disease database, respectively. The satisfactory prediction performance suggests that GAEMDA model could serve as a reliable tool to guide the following researches on the regulatory role of miRNAs. Besides, the source codes are available at https://github.com/chimianbuhetang/GAEMDA.

An anomaly detection method based on double encoder–decoder generative adversarial networks

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Hui Liu ◽  
Tinglong Tang ◽  
Jake Luo ◽  
Meng Zhao ◽  
Baole Zheng ◽  
...  
Keyword(s):  
Anomaly Detection ◽  
Latent Variables ◽  
Dimensional Space ◽  
Superior Performance ◽  
Generative Adversarial Networks ◽  
Training Process ◽  
Content Type ◽  
Detection Model ◽  
Adversarial Networks ◽  
Low Dimensional

Purpose This study aims to address the challenge of training a detection model for the robot to detect the abnormal samples in the industrial environment, while abnormal patterns are very rare under this condition. Design/methodology/approach The authors propose a new model with double encoder–decoder (DED) generative adversarial networks to detect anomalies when the model is trained without any abnormal patterns. The DED approach is used to map high-dimensional input images to a low-dimensional space, through which the latent variables are obtained. Minimizing the change in the latent variables during the training process helps the model learn the data distribution. Anomaly detection is achieved by calculating the distance between two low-dimensional vectors obtained from two encoders. Findings The proposed method has better accuracy and F1 score when compared with traditional anomaly detection models. Originality/value A new architecture with a DED pipeline is designed to capture the distribution of images in the training process so that anomalous samples are accurately identified. A new weight function is introduced to control the proportion of losses in the encoding reconstruction and adversarial phases to achieve better results. An anomaly detection model is proposed to achieve superior performance against prior state-of-the-art approaches.

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