scholarly journals The Cellular Immune Response to Rabies Vaccination: A Systematic Review

Vaccines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 110 ◽  
Author(s):  
Overduin ◽  
van Dongen ◽  
Visser

The effectiveness of rabies vaccines is conventionally determined by serological testing. In addition to this assessment of humoral immunity, cellular immunity could help assess effectiveness and protection through a broad range of parameters. Therefore, this study aimed to systematically review all literature on the kinetics and composition of the cellular immune response to rabies vaccination in humans. A total of 1360 studies were identified in an extensive literature search. Twenty studies were selected for inclusion. In a primary response, plasma cells are detectable from day 7 to day 14, peaking at day 10. Memory B-cells appear from day 10 up to at least day 28. After revaccination, natural killer (NK) cells are the first detectable cellular parameters. Further research is required to assess cellular parameters in relation to long-term (serological) immunity. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42019134416.

2017 ◽  
Vol 89 (12) ◽  
pp. 2235-2238
Author(s):  
Amreen Zia ◽  
Dharamveer Singh ◽  
Swati Saxena ◽  
Jyoti Umrao ◽  
Manjari Baluni ◽  
...  

2002 ◽  
Vol 6 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Beatríz Sierra ◽  
Gissel García ◽  
Ana B. Pérez ◽  
Luis Morier ◽  
Rayner Rodríguez ◽  
...  

2015 ◽  
Vol 4 (1) ◽  
pp. 68 ◽  
Author(s):  
Manjunatha Muniswamappa Venkataswamy ◽  
Shampur Narayan Madhusudana ◽  
Sampada Sudarshan Sanyal ◽  
Shaheen Taj ◽  
Ashwin Yajaman Belludi ◽  
...  

2009 ◽  
Vol 22 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Teeraporn Chinchai ◽  
Chintana Chirathaworn ◽  
Kesmanee Praianantathavorn ◽  
Apiradee Theamboonlers ◽  
Yanee Hutagalung ◽  
...  

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  

2004 ◽  
Vol 146 (4) ◽  
pp. 159-172 ◽  
Author(s):  
D. Müller-Doblies ◽  
S. Baumann ◽  
P. Grob ◽  
A. Hülsmeier ◽  
U. Müller-Doblies ◽  
...  

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