scholarly journals Virus Zika (ZIKV): Struktur, Patogenesis, Diagnosis Laboratorium, dan Pencegahan

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Luh Ade Wilan Krisna

Virus Zika (ZIKV) adalah flavivirus yang berhubungan dengan dengue, virus demam kuning, virus Japanese encephalitis dan virus west nile. Virus tersebut menyebabkan infeksi melalui gigitan nyamuk yang dikenal sebagai demam zika atau penyakit zika. Virus zika baru-baru ini menarik perhatian dunia pada pertengahan tahun 2016 karena adanya explosive pandemic di berbagai negara, termasuk di Indonesia. Penelitian telah menemukan bukti bahwa Zika dapat berhubungan dengan cacat kelahiran dan kondisi syaraf seperti microcephaly dan sindrom Guillain-Barre pada orang dewasa. Kata kunci: Zika virus, flavivirus, microcephaly, Guillain-Barre Syndrome

2019 ◽  
Vol 268 ◽  
pp. 53-55 ◽  
Author(s):  
José A. Boga ◽  
Marta E. Alvarez-Arguelles ◽  
Susana Rojo-Alba ◽  
Mercedes Rodríguez ◽  
María de Oña ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Rafail Beshai ◽  
Daniel Bibawy ◽  
Joseph Bibawy

West Nile virus (WNV) is an arthropod-borne flavivirus belonging taxonomically to the Japanese encephalitis subgroup. Usually, it is transmitted by Culex pipiens mosquitoes. Consequently, an increase in WNV-positive mosquitoes presents a rise of the number of patients, as it has been seen in NYC. We present a 65-year-old patient with WNV infection who presented with Guillain–Barré syndrome (GBS). She had a rapidly progressing ascending paralysis, a common feature in GBS patients but an uncommon presentation in WNV. Realizing WNV as an emerging pathogen along with its uncommon presentation of GBS can be potentially lifesaving if caught at an early stage.


2020 ◽  
Vol 3 (4) ◽  
pp. 246-252
Author(s):  
Mateus Do Rosário

A infecção pelo vírus zika está associada ao desenvolvimento da Síndrome de Guillain-Barré (SGB), uma doença autoimune neurológica causada pelo reconhecimento imune de gangliosídeos e outros componentes nas membranas das células neuronais. Utilizando ELISA de alto rendimento, analisamos o perfil de anticorpos anti-glicolipídeos, incluindo gangliosídeos, de amostras de plasma de pacientes com infecções por zika associadas ou não à SGB em Salvador, Bahia, Brasil. Observamos que os pacientes infectados com o zika vírus que desenvolvem SGB apresentam níveis mais altos de anticorpos antigangliosídeos quando comparados com pacientes infectados com zika sem SGB. Também observamos que um amplo repertório de gangliosídeos foi direcionado por auto anticorpos anti IgM e IgG nesses pacientes. Como o vírus zika infecta neurônios, que contêm gangliosídeos de membrana, a apresentação antigênica dessas células infectadas pode estimular os autoanticorpos anti-gangliosídeos observados, sugerindo que os autoanticorpos induzidos diretamente pela infecção podem levar ao desenvolvimento de SGB. Nossos resultados estabelecem, coletivamente, uma ligação entre anticorpos antigangliosídeos e SGB associado ao zika vírus.   Resumo do Artigo: Rivera-Correa J, de Siqueira IC, Mota S, do Rosário MS, Pereira de Jesus PA, Alcantara LCJ, et al. Anti-ganglioside antibodies in patients with zika virus infectionassociated Guillain-Barré Syndrome in Brazil. PLoS Negl Trop Dis. 2019;13(9):e0007695. https://doi.org/10.1371/journal.pntd.0007695.


2021 ◽  
Vol 12 ◽  
Author(s):  
Thomas Langerak ◽  
Irene van Rooij ◽  
Laura Doornekamp ◽  
Felicity Chandler ◽  
Mark Baptista ◽  
...  

Guillain-Barré syndrome (GBS) is associated with various types of preceding infections including Campylobacter jejuni and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinical characteristics of 12 GBS patients from Suriname that were hospitalized between the beginning of 2016 and half 2018. Extensive diagnostic testing was performed for pathogens that are commonly associated with GBS, but also for arboviruses, in order to identify the preceding infection that might have led to GBS. With this extensive testing algorithm, we could identify a recent infection in six patients of which four of them had evidence of a recent Zika virus or dengue virus infection. These results suggest that arboviruses, specifically Zika virus but possibly also dengue virus, might be important causative agents of GBS in Suriname. Furthermore, we found that more accessibility of intravenous immunoglobulins or plasma exchange could improve the treatment of GBS in Suriname.


Neurology ◽  
2000 ◽  
Vol 55 (1) ◽  
pp. 144-146 ◽  
Author(s):  
S. Ahmed ◽  
R. Libman ◽  
K. Wesson ◽  
F. Ahmed ◽  
K. Einberg

2017 ◽  
Vol 8 ◽  
Author(s):  
Ángela Vázquez-Calvo ◽  
Nereida Jiménez de Oya ◽  
Miguel A. Martín-Acebes ◽  
Emilia Garcia-Moruno ◽  
Juan-Carlos Saiz

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