Faculty Opinions recommendation of Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation.

AbstractRecent work identified that patterns of distributed brain regions sharing similar myeloarchitecture are related to underlying functional connectivity, demonstrating cortical myelin’s plasticity to changes in functional demand. However, the changing relation between functional connectivity and structural architecture throughout child and adulthood is poorly understood. We show that structural covariance connectivity measured using T1-weighted/T2-weighted ratio and functional connectivity measured using magnetoencephalography exhibit nonlinear developmental changes. We then show significant relations between structural and functional connectivity, which have both shared and distinct characteristics dependent on the neural oscillatory frequency. Increases in structure-function coupling are visible during the protracted myelination observed throughout childhood and adolescence, and are followed by decreases near the onset of adulthood to potentially support increasing cognitive flexibility and functional specialization in adulthood. Our work lays the foundation for understanding the mechanisms by which myeloarchitecture supports brain function, enabling future investigations into how clinical populations may deviate from normative patterns.

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A challenge for predictive coding: Representational or experiential diversity?

Behavioral and Brain Sciences ◽

10.1017/s0140525x19003157 ◽

2020 ◽

Vol 43 ◽

Author(s):

Martina G. Vilas ◽

Lucia Melloni

Keyword(s):

Brain Function ◽

Predictive Coding ◽

Predictive Processing ◽

Process Theory

Abstract To become a unifying theory of brain function, predictive processing (PP) must accommodate its rich representational diversity. Gilead et al. claim such diversity requires a multi-process theory, and thus is out of reach for PP, which postulates a universal canonical computation. We contend this argument and instead propose that PP fails to account for the experiential level of representations.

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Spherulitic crystal growth in the prodissoconch larval of Crassostrea virginica

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100076263 ◽

1983 ◽

Vol 41 ◽

pp. 518-519

Author(s):

George G. Cocks ◽

Louis Leibovitz ◽

DoSuk D. Lee

Keyword(s):

Crystal Structure ◽

Crassostrea Virginica ◽

Crystal Orientation ◽

Developmental Changes ◽

Gastrula Stage ◽

Orthorhombic Crystal ◽

Orthorhombic Crystal Structure ◽

Stages Of Growth ◽

Early Stages ◽

Initial Deposition

Our understanding of the structure and the formation of inorganic minerals in the bivalve shells has been considerably advanced by the use of electron microscope. However, very little is known about the ultrastructure of valves in the larval stage of the oysters. The present study examines the developmental changes which occur between the time of conception to the early stages of Dissoconch in the Crassostrea virginica(Gmelin), focusing on the initial deposition of inorganic crystals by the oysters.The spawning was induced by elevating the temperature of the seawater where the adult oysters were conditioned. The eggs and sperm were collected separately, then immediately mixed for the fertilizations to occur. Fertilized animals were kept in the incubator where various stages of development were stopped and observed. The detailed analysis of the early stages of growth showed that CaCO3 crystals(aragonite), with orthorhombic crystal structure, are deposited as early as gastrula stage(Figuresla-b). The next stage in development, the prodissoconch, revealed that the crystal orientation is in the form of spherulites.

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Toward a neuroscope: An application of high-performance computing for real-time evaluation of brain function using MRI

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100172346 ◽

1994 ◽

Vol 52 ◽

pp. 922-923

Author(s):

C. S. Potter ◽

C. D. Gregory ◽

H. D. Morris ◽

Z.-P. Liang ◽

P. C. Lauterbur

Keyword(s):

Human Brain ◽

Brain Function ◽

High Performance ◽

Complex Signal ◽

Time Step ◽

Brain Organization ◽

Cognitive Studies ◽

Positron Emission ◽

Imaging And Spectroscopy ◽

3D Anatomy

Over the past few years, several laboratories have demonstrated that changes in local neuronal activity associated with human brain function can be detected by magnetic resonance imaging and spectroscopy. Using these methods, the effects of sensory and motor stimulation have been observed and cognitive studies have begun. These new methods promise to make possible even more rapid and extensive studies of brain organization and responses than those now in use, such as positron emission tomography.Human brain studies are enormously complex. Signal changes on the order of a few percent must be detected against the background of the complex 3D anatomy of the human brain. Today, most functional MR experiments are performed using several 2D slice images acquired at each time step or stimulation condition of the experimental protocol. It is generally believed that true 3D experiments must be performed for many cognitive experiments. To provide adequate resolution, this requires that data must be acquired faster and/or more efficiently to support 3D functional analysis.

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