DMSP – Database for Modeling Signaling Pathways

2008 ◽  
Vol 47 (02) ◽  
pp. 104-148
Author(s):  
M. Breit ◽  
B. Pfeifer ◽  
C. Baumgartner ◽  
R. Modre-Osprian ◽  
B. Tilg ◽  
...  
Keyword(s):  
Knowledge Base ◽  
Signaling Pathways ◽  
Protein Interaction ◽  
Initial Step ◽  
Point Of View ◽  
Biological Knowledge ◽  
Literature Study ◽  
Online Databases ◽  
Qualitative Level ◽  
Pathway Models

Summary Objectives: Presently, the protein interaction information concerning different signaling pathways is available in a qualitative manner in different online protein interaction databases. The challenge here is to derive a quantitative way of modeling signaling pathways from qualitative way of modeling signaling pathways from a qualitative level. To address this issue we developed a database that includes mathematical modeling knowledge and biological knowledge about different signaling pathways. Methods: The database is part of an integrative environment that includes environments for pathway design, visualization, simulation and a knowledge base that combines biological and modeling information concerning pathways. The system is designed as a client-server architecture. It contains a pathway designing environment and a simulation environment as upper layers with a relational knowledge base as the underlying layer. Results: DMSP – Database for Modeling Signaling Pathways incorporates biological datasets from online databases like BIND, DIP, PIP, and SPiD. The modeling knowledge that has been incorporated is based on a literature study. Pathway models can be designed, visualized and simulated based on the knowledge stored in the DMSP. The user can download the whole dataset and build pathway models using the knowledge stored in our database. As an example, the TNF? pathway model was implemented and tested using this approach. Conclusion: DMSP is an initial step towards the aim of combining modeling and biological knowledge concerning signaling pathways. It helps in understanding pathways in a qualitative manner from a qualitative level. Simulation results enable the interpretation of a biological system from a quantitative and systemtheoretic point of view.

scholarly journals Private retirement resorts in South Africa: Guidelines for wellness and sustainability in the long term.

2013 ◽  
Vol 32 (1) ◽  
Author(s):  
Andries C. Hauptfleisch
Keyword(s):  
South Africa ◽  
Knowledge Base ◽  
Quantitative Data ◽  
Qualitative Data ◽  
Well Being ◽  
The Other ◽  
Literature Study ◽  
Optimal Profile

Unsubsidised private retirement resorts in South Africa developed during the last three decades present residents with many challenges. There is no existing generally accepted knowledge base or guidelines to serve this sensitive market. The research objective was to establish which elements are experienced by residents of retirement resorts as satisfactory and which as problematic. A literature study was also undertaken. Quantitative as well as qualitative data were obtained by means of structured questionnaires, interviews and a seminar. The results reported pertain to eight resorts in the east of Pretoria, four in Bloemfontein and two in Knysna. The study is currently being extended to other centres. The quantitative data is arranged in order of the priorities set by the biggest group (Pretoria), with the other groups in comparison. So the research was based on the sourcing of quantitative and qualitative data, as well as on descriptive evaluations. The results offer insightful knowledge and guidelines towards establishing an optimal profile for the development of long-term sustainable private retirement resorts. The implications and value of this study are that both developers of retirement resorts and prospective residents are provided with guidelines to better equip them to evaluate a specific retirement resort with regard to the sustainable well- being of residents long-term.

Extending Signaling Pathways with Protein–Interaction Networks. Application to Apoptosis

2012 ◽  
Vol 16 (5) ◽  
pp. 245-256 ◽  
Author(s):  
Joan Planas-Iglesias ◽  
Emre Guney ◽  
Javier García-García ◽  
Kevin A Robertson ◽  
Sobia Raza ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Protein Interaction ◽  
Protein Interaction Networks ◽  
Interaction Networks

DISTANCE-WISE PATHWAY DISCOVERY FROM PROTEIN–PROTEIN INTERACTION NETWORKS WEIGHTED BY SEMANTIC SIMILARITY

2014 ◽  
Vol 12 (01) ◽  
pp. 1450004 ◽  
Author(s):  
SLAVKA JAROMERSKA ◽  
PETR PRAUS ◽  
YOUNG-RAE CHO
Keyword(s):  
Signaling Pathways ◽  
Semantic Similarity ◽  
Protein Interaction ◽  
Protein Pair ◽  
Semantic Analysis ◽  
Topological Analysis ◽  
Cellular Mechanisms ◽  
Semantic Similarity Measure ◽  
Protein Protein Interaction ◽  
Ppi Networks

Reconstruction of signaling pathways is crucial for understanding cellular mechanisms. A pathway is represented as a path of a signaling cascade involving a series of proteins to perform a particular function. Since a protein pair involved in signaling and response have a strong interaction, putative pathways can be detected from protein–protein interaction (PPI) networks. However, predicting directed pathways from the undirected genome-wide PPI networks has been challenging. We present a novel computational algorithm to efficiently predict signaling pathways from PPI networks given a starting protein and an ending protein. Our approach integrates topological analysis of PPI networks and semantic analysis of PPIs using Gene Ontology data. An advanced semantic similarity measure is used for weighting each interacting protein pair. Our distance-wise algorithm iteratively selects an adjacent protein from a PPI network to build a pathway based on a distance condition. On each iteration, the strength of a hypothetical path passing through a candidate edge is estimated by a local heuristic. We evaluate the performance by comparing the resultant paths to known signaling pathways on yeast. The results show that our approach has higher accuracy and efficiency than previous methods.

scholarly journals Pengendang Perempuan Dalam Karawitan Jawa Pengiring Perayaan Ekaristi di Gereja Pugeran Yogyakarta

SELONDING ◽  
2019 ◽  
Vol 14 (14) ◽  
Author(s):  
Andaru Kumara Jati
Keyword(s):  
Catholic Church ◽  
Point Of View ◽  
Literature Study ◽  
Cultural Aspects ◽  
Sacred Heart ◽  
The Social ◽  
Language And Music ◽  
Search Data ◽  
Musical Accompaniment ◽  
Descriptive Method

Eucharist is a sacred and the primary ritual for Catholics, it has adapted to the local culture. This adaption process called inculturation. Some examples of inculturation that is language and music. In Sacred Heart of Jesus Catholic Church Pugeran Yogyakarta, inculturation appears with the eucharist with Javanese language and Javanese songs with Javanese musical accompaniment called gamelan. Gamelan is a set of musical instruments that have undergone many developments. Gamelan played generally by men, because the gamelan construction is designed to be played by sitting of male style. But today there’s more and more groups of gamelan involving women as a player. In Pugeran Church found the phenomenon of female kendang (drums) player. This woman has a position as a leader, and it is in contrast to Javenese culture which has patriarchal principle, so that in this research examined the cause of the female kendang player in Catholic church and her performances.The method used in this research is descriptive method of analysis that describes the object in writing and detail. The research is qualitative research with ethnomusicological approach that explores the object not only the form of music (textual) but also all related cultural aspects (contextual). In addition, this research also uses a sociological and theological approach that helps to explore from a socio-cultural point of view and the science of Catholicism. Search data consists by literature study, observation, interviews and documentation. All data is done from October 2017 until June 2018. This research using gender theory in The Social Psychology of Music by David J. Hargreaves and Adrian C. North to analyze the data and answer the problems.

scholarly journals Cultural Acculturation of Yemeni Zapin Dance and Malay Dance in Malaysia As A Means of Islmic Teaching

Jurnal CMES ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 60
Author(s):  
Hafis Muzakir ◽  
Ahmad Jazuli
Keyword(s):  
Data Collection ◽  
Research Literature ◽  
Musical Instruments ◽  
Point Of View ◽  
Literature Study ◽  
Collection Method ◽  
Historical Approach ◽  
Data Collection Method ◽  
Cultural Diffusion ◽  
Descriptive Qualitative

<p>This research was conducted to explain the cultural acculturation of the Yemeni and Malay zapin dance as a means of da'wah Islamiyah in Malaysia. The method used in this research is descriptive qualitative. In this research, literature study was also carried out as a data collection method. There is a theory in this research, namely the theory of cultural diffusion and from the point of view of a historical approach. The aim of this research is to reveal the acculturation elements of the Yemeni and Malay zapin dance. Then describe the Islamic da'wah function and the value between the two parties behind the zapin dance. The results that can be concluded from the acculturation of the Yemeni zapin dances and the Malay dances in Malaysia are producing all kinds of changes including the elements of dancers, musical instruments, movements, and the lyrics or songs used in these dances.</p>

scholarly journals PEMIKIRAN FAZLUR RAHMAN TENTANG PENDIDIKAN DAN RELEVANSINYA DALAM DUNIA MODERN

2019 ◽  
Vol 1 (4) ◽  
pp. 408-424
Author(s):  
Dwy Purwaningsih
Keyword(s):  
Public Education ◽  
Human Life ◽  
Human Person ◽  
Secondary Data ◽  
Initial Step ◽  
Point Of View ◽  
Islamic Education ◽  
Primary Data ◽  
Modern World ◽  
Educational Thought

Pragmatic education thought-instrumental is a philosophic point of view that blends with the religious viewpoint of abstract speculation in outlining the education. One of renewing Islamic education is Fazlur Rahman. According to him, the goal of Islamic education are as renewal which is the initial step in the Islamization for all aspects of human life. The study of library (library research) i.e. research sourced from material libraries using a qualitative approach. In this case, the author does exploration of a number of primary data as well as secondary data. The author does an analysis of the concept of Islamic education prespective Fazlur Rahman and relevance against the modern world. The concept of educational thought Fazlur Rahman i.e. the Qur'an as a guide in resolving every problem and the answer and make the human person that are creative, have moral values in accordance with the Qur'an. Whereas, education as an alternative to the secular science by receiving updates and tried to enter it with Islamic concepts as for Islamic education renewal effort started from the educational objectives, educational system, learners, educators and the means of education. The relevance of educational thought on modern world Fazlur Rahman now is integration between religion and discrimination through public education, omission of religion and public education, this has been done wrong by the College namely IAIN with try to follow the thinking of education Fazlur Rahman dare change the State Islamic University (UIN).

Analisis Hukum Islam dan Undang-Undang No. 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik terhadap Jual Beli Data Supplier di Agen Fashion

2020 ◽  
pp. 75
Author(s):  
Nur'aeni Nasifah ◽  
Siska Lis Sulistiani ◽  
Yayat Rahmat Hidayat
Keyword(s):  
Data Collection ◽  
Qualitative Method ◽  
Islamic Law ◽  
Descriptive Analysis ◽  
Secondary Data ◽  
Point Of View ◽  
Supplementary Data ◽  
Literature Study ◽  
Face To Face

Abstract. Sale and purchase is transaction that often done by individual or group because there is a transfer of ownership between goods and assets. In practice, sale and purchase is not only done by face to face but also can be done online, as in the case of the sale and purchase of suppliers data at Agen Fashion. This study aims to find out how the transaction practice is and how Islamic law and ITE Law point of view are, whether it is accordance to the laws or not. This research uses qualitative method with normative juridical approach and literature study. The main sources in this study are secondary data that support this research, such as Alquran, Hadith, and the ITE Law. The interviews as data collection techniques are conducted as supplementary data. The analytical method used is descriptive analysis. The results of this study are the transaction is not  accordance with the terms of sale and purchase in Islamic law because there is a lack of clarity (gharar) on the quality of the object and is not accordance as well as the clause no. 9 of the ITE Law because the seller did not explain the object completely.Keywords: Sale and Purchase, Islamic Law, ITE Law, GhararAbstrak. Jual beli merupakan bentuk transaksi yang sering dilakukan oleh tiap individu atau kelompok karena dalam jual beli terdapat perpindahan kepemilikan antara barang dan harta untuk memenuhi kebutuhan hidup. Pada praktiknya, jual beli tidak hanya dilakukan secara bertatap muka melainkan dapat dilakukan secara online, seperti halnya pada jual beli data supplier di Agen Fashion. Penelitian ini bertujuan untuk mengetahui bagaimana praktik jual beli data supplier di Agen Fashion serta bagaimana hukum Islam dan Undang-Undang No. 11 Tahun 2008 Tentang Informasi dan Transaksi Elektronik memandang praktik jual beli data supplier tersebut, apakah telah sesuai dengan hukum yang menjadi pisau analisis dalam penelitian ini atau belum. Penelitian ini menggunakan metode kualitatif dengan pendekatan yuridis normatif dan studi kepustakaan. Sumber utama dalam penelitian ini adalah data sekunder yang mendukung penelitian ini, yaitu Alquran, Hadis, dan UU ITE. Sedangkan teknik pengumpulan data berupa wawancara dilakukan sebagai data pelengkap. Metode analisis yang digunakan yaitu descriptive analysis. Hasil dari penelitian ini adalah transaksi yang terjadi di Agen Fashion tidak sesuai dengan syarat jual beli dalam hukum Islam karena terdapat ketidakjelasan (gharar) pada kualitas objek transaksi, dan tidak sesuai dengan Pasal 9 dalam UU ITE karena pelaku usaha tidak menjelaskan secara lengkap terkait objek yang ditawarkan.Kata Kunci: Jual Beli, Hukum Islam, UU ITE, Gharar

scholarly journals Particles Ka(h) of Indonesian and Japanese: Cross Linguistic Study

IZUMI ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 23-30
Author(s):  
Maharani Patria Ratna
Keyword(s):  
Point Of View ◽  
Distribution Characteristic ◽  
Literature Study ◽  
Linguistic Study ◽  
Free Distribution ◽  
The World ◽  
Similarities And Differences ◽  
Japanese Linguistics ◽  
Indefinite Pronoun

Some languages in the world have particles with their respective functions. One of them is Ka(h) particle which is used both in Indonesian and Japanese. Both are equally used as markers of the question sentence. In Indonesian the ka(h) particle is pronounced "Kah" while in Japanese it is pronounced "Ka.” The purpose of this study is to identify what are the similarities and differences in the use of Ka(h) particles in Indonesian and Japanese. the data is taken by a literature study in Indonesian linguistics and Japanese linguistics. These similarities and differences will be studied through aspects of characteristics, function, location, and intonation. Both particles are enclitic and arbitrary, but only Kah particle has a free distribution characteristic. On the function of point of view, both particles are question marker, but only The Ka particle functioned as a choice marker and indefinite pronoun. The results of this study indicate that in Indonesian the use of Kah particles is always pronounced with rising intonation, whereas in Japanese the "ka" particle can be pronounced with rising or falling intonation. Also both particles can be located in the middle and at the end of the sentence. 

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