scholarly journals The Impact of Body Morphology on Rotation on Chest Radiograph: A Single Centre Study

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Ogoke AO ◽  
Ugwu AC ◽  
Ugwuanyi DC ◽  
Ohagwu CC ◽  
Ogolodom MP ◽  
...  
2020 ◽  
Vol 35 (2) ◽  
pp. 346-356
Author(s):  
Nicole Bischof ◽  
Caroline Wehmeier ◽  
Michael Dickenmann ◽  
Patricia Hirt-Minkowski ◽  
Patrizia Amico ◽  
...  

Abstract Background Cytomegalovirus (CMV) serostatus and CMV replication are considered as risk factors for inferior graft and patient survival after renal transplantation, but long-term outcome data are limited. The aim of this retrospective single-centre study was to investigate the impact of CMV serostatus and CMV replication/disease on long-term outcomes in a well-defined cohort managed by a standardized CMV prevention/treatment protocol. Methods We investigated 599 consecutive kidney transplantations having a CMV prevention protocol consisting of either prophylaxis (D+/R− and R+ with ATG induction) or screening/deferred therapy (R+ without ATG induction). Patients were grouped according to CMV serostatus [high risk (D+/R−): n = 122; intermediate risk (R+): n = 306; low risk (D−/R−): n = 171] and occurrence of CMV replication/disease (no CMV replication: n = 419; asymptomatic CMV replication: n = 110; CMV syndrome: n = 39; tissue-invasive CMV disease: n = 31). The median follow-up time was 6.5 years. Results Graft and patient survival were not different among the three CMV serostatus groups as well as the four CMV replication/disease groups (P ≥ 0.44). Eighty-seven patients died, 17 due to infections (21%), but none was attributable to CMV. The overall hospitalization incidence for CMV-related infection was 3% (17/599 patients). The incidence of clinical and (sub)clinical rejection was similar among the groups (P ≥ 0.17). In a multivariate Cox proportional hazard model, neither CMV serostatus, nor CMV replication, nor CMV disease were independent predictors for patient death or graft failure, respectively. Conclusions This retrospective single-centre study suggests that the negative impact of CMV infection on long-term patient and allograft survival as well as on allograft rejection can be largely eliminated with current diagnostic/therapeutic management.


2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Birute Zilaitiene ◽  
Marius Dirzauskas ◽  
Rasa Verkauskiene ◽  
Rytas Ostrauskas ◽  
Joerg Gromoll ◽  
...  

2016 ◽  
Vol 22 (3) ◽  
pp. S192
Author(s):  
Revathi Raj ◽  
Sreejith Ramachandran ◽  
Ramya Uppuluri ◽  
Divya Subburaj ◽  
Atish Bakane ◽  
...  

2020 ◽  
Vol 35 (9) ◽  
pp. 1595-1601
Author(s):  
Annabel Boyer ◽  
Ivonne Solis-Trapala ◽  
Matthew Tabinor ◽  
Simon J Davies ◽  
Mark Lambie

Abstract Background There is limited information available on the impact that provision of an assisted peritoneal dialysis (PD) service has on the initiation of PD. The aim of this study was to assess this impact in a centre following initiation of assisted PD in 2011. Methods This retrospective, single-centre study analysed 1576 patients incident to renal replacement therapies (RRTs) between January 2002 and 2017. Adjusted Cox regression with a time-varying explanatory variable and a Fine and Gray model were used to examine the effect of assisted PD use on the rates and cumulative incidence of PD initiation, accounting for the non-linear impact of RRT starting time and the competing risks (transplant and death). Results Patients starting PD with assistance were older than those starting unassisted: median (interquartile range): 70.0 (61.5–78.3) versus 58.7 (43.8–69.2) years old, respectively. In the adjusted analysis assisted PD service availability was associated with an increased rate of PD initiation [cause-specific hazard ratio (cs-HR) 1.78, 95% confidence interval 1.21–2.61]. During the study period, the rate of starting PD fell before flattening out. Transplantation and death rates increased over time but this did not affect the fall in PD initiation [for each year in the study cs-HR of starting PD 0.95 (0.93–0.98), sub-distribution HR 0.95 (0.94–0.97)]. Conclusions In a single-centre study, introducing an assisted PD service significantly increased the rate of PD initiation, benefitting older patients most. This offsets a fall in PD usage over time, which was not explained by changes in transplantation or death.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sumesh Padayachee ◽  
Ahmed Adam ◽  
June Fabian

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