scholarly journals Article Review: Cordia myxa L.: The Gift of the Nature, A Review

2021 ◽  
Vol 34 (2) ◽  
pp. 267-277
Author(s):  
Sarah A. Al-Khafaji ◽  
Mohenned A. Alsaadawi ◽  
Ali M. Al-Yasari ◽  
Moyed A. Al-Saadawe
Keyword(s):  
Phenolic Content ◽  
Future Research ◽  
Gram Negative Bacteria ◽  
Toxic Heavy Metals ◽  
The Gift ◽  
Cordia Myxa ◽  
Parasitic Activity ◽  
Medical Plants ◽  
Medicinal Activity ◽  
Sodium And Potassium

Cordia myxa L. is one of the medical plants that plays an important role in the treatment of many diseases. There are many studies explained that C. myxa can show anti-inflammatory, anti-diabetic, antiparasitic, antimicrobial and immunomodulatory properties. This review was focused on the active compounds and medical effects of C. myxa. The fatty acids contents are particularly high (9.9%). Sodium and potassium constitute the largest mineral proportion (13 ppm and 29 ppm respectively) of the fruit. However, the toxic heavy metals such as lead, cadmium, chromium and copper have not been found in the fruit. This gives an additional significant benefit of the medical uses of the plant. The content of alkaloids, saponin, polyphenols, and comarine were recorded and was relatively high compared to steroids, resins, glycosides, tannins, and gum that found to be in less amounts. When the mucilage was extracted, the alkaloids constitute more than 35%. By using the Folin‐Ciocalteu, C. myxa extracts have a high Phenolic content. The antibacterial activity against gram-negative bacteria were included in the fruit mucilage extract while the alcoholic extracts have no effect on all bacterial isolates. In addition, the mucilage extract showed anti-parasitic activity when it was tested against Leishmania infantum promastigotes. However, the highest concentration of extract significantly reduced the amounts of lymphocytes. Moreover, ethanolic extracts of C. myxa fruits give rise to leucocyte and lymphocyte count. Future research needs to be done on this kind of herbs which could show high medicinal activity.

Chemical Constituents and Biological Activities of Cordia Myxa L.: A Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Varinder Singh ◽  
Ankita Sood ◽  
Simran Pruthi ◽  
Manjinder Singh ◽  
Balraj Saini ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Functional Health ◽  
Future Research ◽  
Health Food ◽  
Toxicological Evaluation ◽  
Cordia Myxa ◽  
Chronic Fever ◽  
Tract Infections

Background: Cordia myxa L. (CM) is a valuable ethnomedicinal plant from Boraginaceae family. Traditionally, CM parts especially fruits and leaves are used in chest and urinary tract infections, diarrhoea, dysentery, tuberculosis, liver and spleen disorders, chronic fever, malaria etc. Objective: Despite of known importance and uses, CM has gained relatively less attention of researchers and concise reviews revealing the medicinal potential of CM are scanty. The present review summarizes the chemical constituents and biological activities of CM and aims to stimulate future research to develop it as a functional health food. Results: Analysis of literature on CM showed that its fruits are a rich source of nutrients and are frequently employed in wide ailments such as urinary and respiratory tract infections, chronic fever, liver disorders, asthma, used as anthelmintic, diuretic, expectorant and purgative. Scientific studies have shown the antidiabetic, analgesic, anti-inflammatory, anti-cancer, antioxidant, antiplasmodial, hepatoprotective, hypotensive, antiulcer and antimicrobial activities of CM. More than 45 compounds belonging to carbohydrates, steroids, carotenoids, phenols, flavonoids and alkaloids have been reported from various parts of CM. Conclusion: Systematic preclinical studies support the traditional claims of CM. The analysis of available literature showed that CM could be developed as a drug. Further, studies such as detailed pharmacological and toxicological evaluation, isolation of bioactive compounds, quantitative phytochemistry and structure activity relationship are scanty and thus, crucial to be addressed for uplifting the scientific value of this revered medicinal plant.

scholarly journals The Efficacy of Psidium guajava Linn Leaf Extractsfrom Selangor Region Against Gram-Positive and Gram-Negative Bacteria

2018 ◽  
Vol 54 (4) ◽  
pp. 294
Author(s):  
S Zuhaira ◽  
Noorhaniz Mohd Nizam ◽  
PM Ridzuan
Keyword(s):  
Methanol Extract ◽  
Psidium Guajava ◽  
Diffusion Method ◽  
Future Research ◽  
Phytochemical Analysis ◽  
Gram Negative Bacteria ◽  
Leaf Extracts ◽  
Gram Positive ◽  
Gram Negative ◽  
Freeze Dried

Antibiotic is a type of medication that helps in fighting bacterial infection. Treating bacterial infections in clinical setting become more complicated and costly due to drug resistance. This study was conducted to determine the antibacterial potential of Psidium guajava Linn leaf extracts against Gram-positive and Gram-negative bacteria. P. guajava Linn leaf was obtained from Research Orchards at University Putra Malaysia (UPM). Leaves were extracted using three types of extracts; hot, cold and methanol extract. Freeze dried was used in this study and temperature was set at -104°C for 24 hours. Antibacterial testing was determined using disc diffusion and well diffusion method. Antibacterial activity was evaluated by measuring the inhibitory zone of the tested bacteria. Phytochemical analysis was conducted by adding few drop of diluted NaOH (Sodium Hydroxide) solution to detect the active flavanoid from leaves extract. Antimicrobial activity showed all extracts were effective against Gram-positive and Gram-negative bacteria. Phytochemical analysis of P. guajava Linn leaf extracts showed the methanol extract indicating the presence of tannins, phenols, flavonoids, terpenoids, glycosides and saponins. Results showed that P. guajava Linn leaf was effective against Gram-positive and Gram-negative bacteria, and pythochemical analysis also exhibited a few active compounds that were determined. P. guajava Linn leaf had potential natural product that may be used for further analysis in the future research.

scholarly journals Could Periodontal Disease through Periopathogen Fusobacterium nucleatum Be an Aggravating Factor for Gastric Cancer?

2020 ◽  
Vol 9 (12) ◽  
pp. 3885
Author(s):  
Petra Șurlin ◽  
Flavia Mirela Nicolae ◽  
Valeriu Marin Șurlin ◽  
Ștefan Pătrașcu ◽  
Bogdan Silviu Ungureanu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Periodontal Disease ◽  
Anaerobic Bacterium ◽  
Fusobacterium Nucleatum ◽  
Negative Influence ◽  
Chronic Inflammatory Disease ◽  
Periodontal Pathogen ◽  
Future Research ◽  
Gram Negative Bacteria ◽  
Gram Negative

Periodontal disease affects the supporting tissues of the teeth, being a chronic inflammatory disease caused by specific microorganisms from subgingival biofilm. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that acts as a periodontal pathogen, being an important factor in linking Gram-positive and Gram-negative bacteria in the periodontal biofilm, but its involvement in systemic diseases has also been found. Several studies regarding the implication of Fusobacterium nucleatum in gastro-enterological cancers have been conducted. The present review aims to update and systematize the latest information about Fusobacterium nucleatum in order to evaluate the possibility of an association between periodontal disease and the evolution of gastroenterological cancers through the action of Fusobacterium nucleatum, highlighting gastric cancer. This would motivate future research on the negative influence of periodontal pathology on the evolution of gastric cancer in patients suffering from both pathologies.

Influence of Sodium Substitution with Potassium on Microbial and Organoleptic Spoilage Patterns in Sliced Vacuum-Packed Pasteurized Pork Loin

1986 ◽  
Vol 49 (12) ◽  
pp. 999-1002 ◽  
Author(s):  
H.-J. S. NIELSEN ◽  
P. ZEUTHEN
Keyword(s):  
Adverse Effect ◽  
Sodium Chloride ◽  
Potassium Chloride ◽  
Aerobic Bacteria ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Brochothrix Thermosphacta ◽  
Sodium Substitution ◽  
Pork Loin ◽  
Sodium And Potassium

Sliced, cured, cooked and smoked pork loin was produced with sodium chloride or a mixture of sodium and potassium chloride, with each preparation of pork loin having the same water activity (0.967–0.968). The pork loins were sliced, vacuum packaged and stored at 2, 5 and 10°C. Microbial spoilage was determined using selective and nonselective media to enumerate total aerobic bacteria, lactics, Brochothrix thermosphacta, gram-negative bacteria and yeasts. Spoilage was also determined using sensory evaluation. Generally, the influence of sodium substitution on microorganisms was minimal. Organoleptic scores were similar for the two preparations of pork loin, hence no adverse effect of sodium substitution was observed.

scholarly journals Bioremediation of Chromium by Microorganisms and Its Mechanisms Related to Functional Groups

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Abate Ayele ◽  
Yakob Godebo Godeto
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Metal Ions ◽  
Functional Groups ◽  
Heavy Metal Ions ◽  
Future Research ◽  
Oil Well ◽  
Toxic Heavy Metals ◽  
Toxic Heavy Metal ◽  
Minimum Concentration

Heavy metals generated mainly through many anthropogenic processes, and some natural processes have been a great environmental challenge and continued to be the concern of many researchers and environmental scientists. This is mainly due to their highest toxicity even at a minimum concentration as they are nonbiodegradable and can persist in the aquatic and terrestrial environments for long periods. Chromium ions, especially hexavalent ions (Cr(VI)) generated through the different industrial process such as tanneries, metallurgical, petroleum, refractory, oil well drilling, electroplating, mining, textile, pulp and paper industries, are among toxic heavy metal ions, which pose toxic effects to human, plants, microorganisms, and aquatic lives. This review work is aimed at biosorption of hexavalent chromium (Cr(VI)) through microbial biomass, mainly bacteria, fungi, and microalgae, factors influencing the biosorption of chromium by microorganisms and the mechanism involved in the remediation process and the functional groups participated in the uptake of toxic Cr(VI) from contaminated environments by biosorbents. The biosorption process is relatively more advantageous over conventional remediation technique as it is rapid, economical, requires minimal preparatory steps, efficient, needs no toxic chemicals, and allows regeneration of biosorbent at the end of the process. Also, the presence of multiple functional groups in microbial cell surfaces and more active binding sites allow easy uptake and binding of a greater number of toxic heavy metal ions from polluted samples. This could be useful in creating new insights into the development and advancement of future technologies for future research on the bioremediation of toxic heavy metals at the industrial scale.

Virginity beliefs in lesbian, gay, and bisexual individuals experiencing same- and different-sex “first” times

2021 ◽  
Author(s):  
Coady Babin ◽  
Terry Humphreys
Keyword(s):  
Sexual Experience ◽  
Qualitative Interviews ◽  
Future Research ◽  
Sexual Experiences ◽  
Same Sex ◽  
Structured Interviews ◽  
Significant Drop ◽  
First Sex ◽  
The Gift ◽  
And Bisexual

The purpose of the current study was to explore first sex experiences in lesbian, gay, and bisexual individuals (LGB) using the Virginity Beliefs Framework ( Carpenter, 2001 ; Humphreys, 2013 ; Eriksson & Humphreys, 2014 ). The specific focus was on LGB individuals who have had both a sexual experience with a member of a different sex and a member of the same sex. This phenomenon is what the current study is defining as second virginity loss. Participants consisted of 275 self-identified LGB individuals; the sample was approximately half women (57%) between the ages of 18 and 56. Further, six semi-structured interviews were conducted to gain a clearer understanding of LGB individuals first sex experiences. Two primary research questions were proposed: (1) how do the virginity belief frames map onto the two “first” sexual experiences of LGB individuals? and (2) are there differences in the virginity belief frames between the two “first” times? Results found that LGB individuals hold stronger process beliefs than gift or stigma beliefs for both of their “first” times. The qualitative interviews suggested that the process of understanding virginity was enmeshed with a larger exploration, and eventual validation, of sexual identity. There was also a significant drop in the strength of some of the gift, process, and stigma beliefs from different-sex experience to same-sex experience for many in the gay and bisexual samples, but not in the lesbian sample. The current study is the first to explore the phenomenon of second virginity loss in LGB individuals and could be used as a foundation for future research on LGB first sexual experiences.

Bioinformatics analysis of diversity in bacterial glycan chain-termination chemistry and organization of carbohydrate-binding modules linked to ABC transporters

Glycobiology ◽  
2019 ◽  
Vol 29 (12) ◽  
pp. 822-838 ◽  
Author(s):  
Evan Mann ◽  
Matthew S Kimber ◽  
Chris Whitfield
Keyword(s):  
Abc Transporter ◽  
Bioinformatics Analysis ◽  
Coiled Coil ◽  
Future Research ◽  
Carbohydrate Binding ◽  
Gram Negative Bacteria ◽  
Glycan Chain ◽  
Carbohydrate Binding Modules ◽  
Molecular Ruler ◽  
A Chain

Abstract The structures of bacterial cell surface glycans are remarkably diverse. In spite of this diversity, the general strategies used for their assembly are limited. In one of the major processes, found in both Gram-positive and Gram-negative bacteria, the glycan is polymerized in the cytoplasm on a polyprenol lipid carrier and exported from the cytoplasm by an ATP-binding cassette (ABC) transporter. The ABC transporter actively participates in determining the chain length of the glycan substrate, which impacts functional properties of the glycoconjugate products. A subset of these systems employs an additional elaborate glycan capping strategy that dictates the size distribution of the products. The hallmarks of prototypical capped glycan systems are a chain-terminating enzyme possessing a coiled-coil molecular ruler and an ABC transporter possessing a carbohydrate-binding module, which recognizes the glycan cap. To date, detailed investigations are limited to a small number of prototypes, and here, we used our current understanding of these processes for a bioinformatics census of other examples in available genome sequences. This study not only revealed additional instances of existing terminators but also predicted new chemistries as well as systems that diverge from the established prototypes. These analyses enable some new functional hypotheses and offer a roadmap for future research.

scholarly journals “You really shouldn't have!” Coping with failed gift experiences

2020 ◽  
Vol 54 (4) ◽  
pp. 857-883 ◽  
Author(s):  
Ines Branco-Illodo ◽  
Teresa Heath ◽  
Caroline Tynan
Keyword(s):  
Future Research ◽  
Structured Interviews ◽  
Ethical Considerations ◽  
Content Type ◽  
Diary Method ◽  
Multiple Data ◽  
The Gift ◽  
Research Findings ◽  
The Cost ◽  
Practical Implications

Purpose This paper aims to examine coping approaches used by receivers to deal with failed gift experiences, thereby dealing with misperceptions between givers and receivers that could affect their relationship. Design/methodology/approach This study uses a sequential, multimethod methodology using background questionnaires, online diary method and 27 semi-structured interviews. Findings Receivers cope with failed gift experiences through concealing, disclosing or re-evaluating the gift experience. These approaches encompass several coping strategies, allowing receivers to deal with their experiences in ways that help them manage their relationships with givers. Research limitations/implications Informants described gift experiences in their own terms without being prompted to talk about coping, thus some insights of coping with failed gifts may have been missed. Multiple data collection methods were used to minimise this limitation, and the research findings suggest new avenues for future research. Practical implications The present research helps retailers and brands to minimise gift failure by promoting gifts that emphasise aspects of the giver–receiver relationship, assists givers in their learning from gift failure by making them aware of the receiver’s preferences and reduces the cost of gift failure by offering further opportunities to dispose of unwanted gifts. Originality/value This paper contributes to the emerging topic of consumer coping by providing a novel and rounded understanding of coping in the context of failed gift events, identifying new reasons for gift failure, highlighting receivers’ ethical considerations when responding to failed gifts and proposing new insights for the coping literature.

scholarly journals Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria

Microbiology ◽  
2014 ◽  
Vol 160 (10) ◽  
pp. 2109-2121 ◽  
Author(s):  
Heramb M. Kulkarni ◽  
Medicharla V. Jagannadham
Keyword(s):  
Outer Membrane ◽  
Membrane Vesicles ◽  
Outer Membrane Vesicles ◽  
Host Cells ◽  
Future Research ◽  
Gram Negative Bacteria ◽  
Biological Functions ◽  
Gram Negative ◽  
Bacterial Quorum ◽  
Membrane Components

Outer membrane vesicles (OMVs) released from Gram-negative bacteria consist of lipids, proteins, lipopolysaccharides and other molecules. OMVs are associated with several biological functions such as horizontal gene transfer, intracellular and intercellular communication, transfer of contents to host cells, and eliciting an immune response in host cells. Although hypotheses have been made concerning the mechanism of biogenesis of these vesicles, research on OMV formation is far from complete. The roles of outer membrane components, bacterial quorum sensing molecules and some specific proteins in OMV biogenesis have been studied. This review discusses the different models that have been proposed for OMV biogenesis, along with details of the biological functions of OMVs and the likely scope of future research.

GIFT Cloud

2016 ◽  
Vol 60 (1) ◽  
pp. 1389-1393 ◽  
Author(s):  
Scott Ososky ◽  
Keith Brawner ◽  
Benjamin Goldberg ◽  
Robert Sottilare
Keyword(s):  
Intelligent Tutoring System ◽  
Lessons Learned ◽  
Future Research ◽  
Authoring Tools ◽  
Web Based ◽  
Initial Release ◽  
The Gift ◽  
User Data ◽  
Computer Based ◽  
Made In

GIFT Cloud is the recently released web-based application version of GIFT, an open-source computer-based tutoring architecture that supports authoring, deployment, and evaluation of intelligent tutoring system technologies. This paper presents the GIFT Cloud Authoring Tools, through the lens of usability. Each major element within the authoring tools is described, along with usability design considerations that were made in order to reduce occurrence of error, to organize information, and to support end-user goals. The initial release of GIFT Cloud supports an iterative design approach, informed by user data and feedback, with an overall goal of making tutor authoring practical for subject matter experts without computer programming or instructional design knowledge. As such, lessons learned from this release, as well as plans for future research and usability improvements, are discussed.

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