Synthesis, Characterization and Biological Activity Evaluation of Novel Pd(II) and Pt(II) Complexes with Heterocyclic Hydrazone Ligands

2007 ◽  
pp. 423-427
Author(s):  
Nenad R. Filipović ◽  
Tamara R. Todorović ◽  
D.M. Sladić ◽  
Irena T. Novaković ◽  
D.A. Jeremić ◽  
...  
Keyword(s):  
Biological Activity ◽  
Activity Evaluation ◽  
Hydrazone Ligands

Neocryptolepine: A Promising Indoloisoquinoline Alkaloid with Interesting Biological Activity. Evaluation of the Drug and its Most Relevant Analogs

2015 ◽  
Vol 15 (17) ◽  
pp. 1683-1707 ◽  
Author(s):  
Enrique Larghi ◽  
Andrea Bracca ◽  
Abel Arroyo Aguilar ◽  
Daniel Heredia ◽  
Jorgelina Pergomet ◽  
...  
Keyword(s):  
Biological Activity ◽  
Activity Evaluation

scholarly journals The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

2018 ◽  
Vol 5 (6) ◽  
pp. 172317 ◽  
Author(s):  
Chang K. Zhao ◽  
Chan Li ◽  
Xian H. Wang ◽  
Yu J. Bao ◽  
Fu H. Yang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cell Growth ◽  
Cancer Treatment ◽  
Cancer Cell ◽  
Therapeutic Potential ◽  
Selective Synthesis ◽  
Cancer Cell Growth ◽  
Activity Evaluation ◽  
Moderate Yield

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

Synthesis, crystal structures, and biological activity of oxovanadium(V) complexes with similar tridentate hydrazone ligands

2014 ◽  
Vol 67 (10) ◽  
pp. 1760-1770 ◽  
Author(s):  
Gui-Hua Sheng ◽  
Xiao Han ◽  
Zhonglu You ◽  
Hai-Hua Li ◽  
Hai-Liang Zhu
Keyword(s):  
Biological Activity ◽  
Crystal Structures ◽  
Hydrazone Ligands

scholarly journals One Pot Synthesis and Biological Activity Evaluation of Novel Schiff Bases Derived from 2-Hydrazinyl-1,3,4-thiadiazole

2013 ◽  
Vol 61 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Kamaleddin Haj Mohammad Ebrahim Tehrani ◽  
Soroush Sardari ◽  
Vida Mashayekhi ◽  
Marjan Esfahani Zadeh ◽  
Parisa Azerang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
One Pot ◽  
Activity Evaluation ◽  
One Pot Synthesis

Synthesis, Characterization and Biological Activity Evaluation of Novel Pd(II) and Pt(II) Complexes with Heterocyclic Hydrazone Ligands

2007 ◽  
Vol 555 ◽  
pp. 423-427 ◽  
Author(s):  
Nenad R. Filipović ◽  
Tamara R. Todorović ◽  
D.M. Sladić ◽  
Irena T. Novaković ◽  
D.A. Jeremić ◽  
...  
Keyword(s):  
Biological Activity ◽  
13C Nmr Spectroscopy ◽  
Chloride Ions ◽  
Planar Geometry ◽  
Moderate Activity ◽  
Coordination Sites ◽  
Ligand Type ◽  
Square Planar ◽  
Derivatives Of ◽  
Hydrazone Ligands

New complexes of Pt(II) with condensation derivatives of ethyl hydrazinoacetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, 1H- and 13C-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.

Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 1932-1945 ◽  
Author(s):  
Xu Han ◽  
Yongying Shi ◽  
Longlong Si ◽  
Zibo Fan ◽  
Han Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Biological Activity ◽  
Sialic Acid ◽  
Virus Entry ◽  
Pentacyclic Triterpene ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Activity Evaluation ◽  
Virus Entry Inhibitors

A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.

scholarly journals SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

2017 ◽  
Vol 126 (1B) ◽  
pp. 127
Author(s):  
Duong Quoc Hoan
Keyword(s):  
Biological Activity ◽  
Acetic Anhydride ◽  
Cell Line ◽  
Cancer Cell ◽  
Condensation Reaction ◽  
Cancer Cell Line ◽  
High Yield ◽  
Curcumin Analog ◽  
Isoxazole Ring ◽  
Activity Evaluation

The acetohydrazides <strong>A5 </strong>containing an isoxazole ring and<strong> B5</strong> containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones <strong>B6</strong> and <strong>B7</strong> were driven from acetohydrazide <strong>B4</strong> by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones  <strong>B7</strong> showing moderate reactivity against KB cancer cell line at <em>IC<sub>50</sub></em> = 57 mg/L.

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