scholarly journals Characterization of a CD44/CD122int Memory CD8 T Cell Subset Generated under Sterile Inflammatory Conditions

2009 ◽  
Vol 182 (6) ◽  
pp. 3846-3854 ◽  
Author(s):  
Florentin-Martial Mbitikon-Kobo ◽  
Marc Vocanson ◽  
Marie-Cécile Michallet ◽  
Martine Tomkowiak ◽  
Anne Cottalorda ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
T Cell Subset ◽  
Inflammatory Conditions ◽  
Memory Cd8 T Cell

Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

immuneACCESS ◽  
2019 ◽  
Author(s):  
Q Haas ◽  
KF Boligan ◽  
C Jandus ◽  
C Schneider ◽  
C Simillion ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Microenvironment ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Melanoma Tumor ◽  
T Cell Subset ◽  
Memory Cd8 T Cell

Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

2019 ◽  
Vol 7 (5) ◽  
pp. 707-718 ◽  
Author(s):  
Quentin Haas ◽  
Kayluz Frias Boligan ◽  
Camilla Jandus ◽  
Christoph Schneider ◽  
Cedric Simillion ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Microenvironment ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Melanoma Tumor ◽  
T Cell Subset ◽  
Memory Cd8 T Cell

scholarly journals A Distinct Lung-Interstitium-Resident Memory CD8 + T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection

Cell Reports ◽  
2016 ◽  
Vol 16 (7) ◽  
pp. 1800-1809 ◽  
Author(s):  
Pavlo Gilchuk ◽  
Timothy M. Hill ◽  
Clifford Guy ◽  
Sean R. McMaster ◽  
Kelli L. Boyd ◽  
...  
Keyword(s):  
T Cell ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
T Cell Subset ◽  
Memory Cd8 T Cell

The clinical significance of CD8+ T cell subset abnormalities in common human malignancies

2002 ◽  
Vol 2 (3) ◽  
pp. 141-154
Author(s):  
Robert L Bjork ◽  
Alan Saven ◽  
Perran R McDaniel ◽  
Terry Bryntesen ◽  
M.Jonathan Worsey ◽  
...  
Keyword(s):  
T Cell ◽  
Clinical Significance ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
T Cell Subset

scholarly journals CXCR5 and ICOS expression identifies a CD8 T-cell subset with TFH features in Hodgkin lymphomas

2018 ◽  
Vol 2 (15) ◽  
pp. 1889-1900 ◽  
Author(s):  
Kieu-Suong Le ◽  
Patricia Amé-Thomas ◽  
Karin Tarte ◽  
Françoise Gondois-Rey ◽  
Samuel Granjeaud ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
T Cell Subset ◽  
Tfh Cells ◽  
Key Points ◽  
Functional Features

Key Points A subset of CD8 T cells in some Hodgkin lymphomas shares phenotypic and functional features with CD4 TFH cells.

IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function

2020 ◽  
Vol 8 (3) ◽  
pp. 321-333 ◽  
Author(s):  
Michael St. Paul ◽  
Samuel D. Saibil ◽  
Scott C. Lien ◽  
SeongJun Han ◽  
Azin Sayad ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
T Cell Subset

scholarly journals Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 ◽  
Vol 186 (9) ◽  
pp. 1407-1418 ◽  
Author(s):  
Dörte Hamann ◽  
Paul A. Baars ◽  
Martin H.G. Rep ◽  
Berend Hooibrink ◽  
Susana R. Kerkhof-Garde ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Fas Ligand ◽  
Cytotoxic T Lymphocyte ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
Cytolytic Activity ◽  
T Cell Subset

Human CD8+ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be found within the circulating human CD8+ T cell subset. First, CD45RA−CD45R0+ cells are reminiscent of memory-type T cells in that they express elevated levels of CD95 (Fas) and the integrin family members CD11a, CD18, CD29, CD49d, and CD49e, compared to naive CD8+ T cells, and are able to secrete not only interleukin (IL) 2 but also interferon γ, tumor necrosis factor α, and IL-4. This subset does not exert cytolytic activity without prior in vitro stimulation but does contain virus-specific cytotoxic T lymphocyte (CTL) precursors. A second primed population is characterized by CD45RA expression with concomitant absence of expression of the costimulatory molecules CD27 and CD28. The CD8+CD45RA+CD27− population contains T cells expressing high levels of CD11a, CD11b, CD18, and CD49d, whereas CD62L (L-selectin) is not expressed. These T cells do not secrete IL-2 or -4 but can produce IFN-γ and TNF-α. In accordance with this finding, cells contained within this subpopulation depend for proliferation on exogenous growth factors such as IL-2 and -15. Interestingly, CD8+CD45RA+CD27− cells parallel effector CTLs, as they abundantly express Fas-ligand mRNA, contain perforin and granzyme B, and have high cytolytic activity without in vitro prestimulation. Based on both phenotypic and functional properties, we conclude that memory- and effector-type T cells can be separated as distinct entities within the human CD8+ T cell subset.

scholarly journals Emergence of a distinct HIV-specific IL-10-producing CD8+T-cell subset with immunomodulatory functions during chronic HIV-1 infection

2013 ◽  
Vol 43 (11) ◽  
pp. 2875-2885 ◽  
Author(s):  
Genevieve Clutton ◽  
Hongbing Yang ◽  
Gemma Hancock ◽  
Nellia Sande ◽  
Cameron Holloway ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
T Cell Subset ◽  
Hiv 1
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