Muscular strength is unaffected by short-term resveratrol supplementation in aged mouse muscle

Author(s):  
CoryW Baumann ◽  
SimonJ Lees ◽  
JeffreyS Otis ◽  
RussellG Rogers
Neuroscience ◽  
1992 ◽  
Vol 48 (1) ◽  
pp. 237-248 ◽  
Author(s):  
H. Kobayashi ◽  
N. Robbins ◽  
U. Rutishauser

2007 ◽  
Vol 21 (2) ◽  
pp. 354 ◽  
Author(s):  
Shane Rogerson ◽  
Robert P. Weatherby ◽  
Glen B. Deakin ◽  
Rudi A. Meir ◽  
Rosanne A. Coutts ◽  
...  

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S184
Author(s):  
Diego de Hoyos ◽  
Andrew Caldwell ◽  
Reisha Caldwell ◽  
Max Shute ◽  
Jesse Barnhill ◽  
...  

1993 ◽  
Vol 463 (1) ◽  
pp. 157-167 ◽  
Author(s):  
S K Phillips ◽  
R W Wiseman ◽  
R C Woledge ◽  
M J Kushmerick

Data in Brief ◽  
2019 ◽  
Vol 22 ◽  
pp. 199-203 ◽  
Author(s):  
Dongwook Yeo ◽  
Chounghun Kang ◽  
Mari Carmen Gomez-Cabrera ◽  
Jose Vina ◽  
Li Li Ji
Keyword(s):  

2019 ◽  
Vol 11 (517) ◽  
pp. eaaw1131 ◽  
Author(s):  
Massiré Traoré ◽  
Christel Gentil ◽  
Chiara Benedetto ◽  
Jean-Yves Hogrel ◽  
Pierre De la Grange ◽  
...  

Deciphering the mechanisms that govern skeletal muscle plasticity is essential to understand its pathophysiological processes, including age-related sarcopenia. The voltage-gated calcium channel CaV1.1 has a central role in excitation-contraction coupling (ECC), raising the possibility that it may also initiate the adaptive response to changes during muscle activity. Here, we revealed the existence of a gene transcription switch of the CaV1.1 β subunit (CaVβ1) that is dependent on the innervation state of the muscle in mice. In a mouse model of sciatic denervation, we showed increased expression of an embryonic isoform of the subunit that we called CaVβ1E. CaVβ1E boosts downstream growth differentiation factor 5 (GDF5) signaling to counteract muscle loss after denervation in mice. We further reported that aged mouse muscle expressed lower quantity of CaVβ1E compared with young muscle, displaying an altered GDF5-dependent response to denervation. Conversely, CaVβ1E overexpression improved mass wasting in aging muscle in mice by increasing GDF5 expression. We also identified the human CaVβ1E analogous and show a correlation between CaVβ1E expression in human muscles and age-related muscle mass decline. These results suggest that strategies targeting CaVβ1E or GDF5 might be effective in reducing muscle mass loss in aging.


2008 ◽  
Vol 295 (2) ◽  
pp. R696-R703 ◽  
Author(s):  
J. Terrien ◽  
P. Zizzari ◽  
M.-T. Bluet-Pajot ◽  
P.-Y. Henry ◽  
M. Perret ◽  
...  

Cold resistance appears altered with aging. Among existing hypotheses, the impaired capacity in response to cold could be related to an altered regulation of plasma IGF-1 concentration. The combined effects of age and cold exposure were studied in a short-living primate, the gray mouse lemur ( Microcebus murinus), which adjusts its energy balance using a daily torpor phase, to avoid high energy cost of normothermia maintenance. Changes in body mass, core temperature, locomotor activity, and caloric intake were monitored under 9-day exposures to 25°C and 12°C in captive animals in winter conditions. Short-term (after 2 days) and long-term (after 9 days) cold-induced changes in IGF-1 levels were also evaluated. In thermoneutral conditions (25°C), general characteristics of the daily rhythm of core temperature were preserved with age. At 12°C, age-related changes were mainly characterized by a deeper hypothermia and an increased frequency of torpor phases, associated with a loss of body mass. A short-term cold-induced decrease in plasma IGF-1 levels was observed. IGF-1 levels returned to basal values after 9 days of cold exposure. No significant effect of age could be evidenced on IGF-1 response. However, IGF-1 levels of cold-exposed aged animals were negatively correlated with the frequency of daily torpor. Responses exhibited by aged mouse lemurs exposed to cold revealed difficulties in the maintenance of normothermia and energy balance and might involve modulations of IGF-1 levels.


2005 ◽  
Vol 8 ◽  
pp. 135
Author(s):  
S. Rogerson ◽  
R. Weatherby ◽  
G. Deakin ◽  
R. Meir ◽  
R. Coutts ◽  
...  

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