Orthokeratinized Odontogenic Cyst: A Rarity

2014 ◽  
Vol 6 (3) ◽  
pp. 23-27
Author(s):  
Heena Sonawane ◽  
Freny R Karjodkar ◽  
Kaustubh Sansare ◽  
Nimish Prakash
Keyword(s):  
Case Report ◽  
Cell Layer ◽  
Granular Cell ◽  
Odontogenic Cyst ◽  
Keratocystic Odontogenic Tumor ◽  
Epithelial Lining ◽  
Basal Cells ◽  
Histological Features ◽  
Granular Cell Layer ◽  
Orthokeratinized Odontogenic Cyst

ABSTRACT Orthokeratinized odontogenic cyst (OOC) was first identified as the rare variant of keratocystic odontogenic tumor (KCOT) for its different histopathology and rare recurrence which was reclassified by WHO in 2005. The orthokeratinized odontogenic cyst is a distinct clinicopathologic entity and is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent granular cell layer. The basal cells are usually cuboidal or flattened. OOC in maxilla is rare. This article presents a case of 56-years-old male patient with OOC in left maxilla. The clinical, radiographic and histological features of the cyst are discussed in this case report.

scholarly journals Orthokeratinized Odontogenic Cyst: A Rarity

2013 ◽  
Vol 5 (3) ◽  
pp. 182-186
Author(s):  
Heena Sonawane ◽  
Freny R Karjodkar ◽  
Kaustubh Sansare ◽  
Nimish Prakash
Keyword(s):  
Case Report ◽  
Cell Layer ◽  
Granular Cell ◽  
Odontogenic Cyst ◽  
Keratocystic Odontogenic Tumor ◽  
Epithelial Lining ◽  
Basal Cells ◽  
Histological Features ◽  
Granular Cell Layer ◽  
Orthokeratinized Odontogenic Cyst

ABSTRACT Orthokeratinized odontogenic cyst (OOC) was first identified as the rare variant of keratocystic odontogenic tumor (KCOT) for its different histopathology and rare recurrence which was reclassified by WHO in 2005. The orthokeratinized odontogenic cyst is a distinct clinicopathologic entity and is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent granular cell layer. The basal cells are usually cuboidal or flattened. OOC in maxilla is rare. This article presents a case of 56-years-old male patient with OOC in left maxilla. The clinical, radiographic and histological features of the cyst are discussed in this case report. How to cite this article Sonawane H, Karjodkar FR, Sansare K, Prakash N. Orthokeratinized Odontogenic Cyst: A Rarity. Int J Otorhinolaryngol Clin 2013;5(3):182-186.

scholarly journals Orthokeratinized Odontogenic Cyst

2012 ◽  
Vol 2 (2) ◽  
pp. 31-33 ◽  
Author(s):  
Niharika Swain ◽  
LS Poonja ◽  
Kamlesh Dekate
Keyword(s):  
Granular Cell ◽  
Odontogenic Cyst ◽  
World Health ◽  
Odontogenic Cysts ◽  
Keratocystic Odontogenic Tumor ◽  
Unusual Site ◽  
Orthokeratinized Odontogenic Cyst ◽  
Odontogenic Origin ◽  
Health Organization ◽  
Anterior Mandible

ABSTRACT Orthokeratinized odontogenic cyst (OOC) is a developmental cyst of odontogenic origin and was initially defined as the uncommon orthokeratinized variant of odontogenic keratocyst (OKC). However, recently World Health Organization has designated OOC as a distinct clinicopathologic entity as it has peculiar clinicopathologic aspects when compared to other developmental odontogenic cysts, especially OKCs. The orthokeratinized odontogenic cyst is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent prominent granular cell layer. The purpose of the article is to present a case of OOC arising in the anterior mandible, an unusual site for the lesion and also highlights the importance of distinguishing it from the more commonly occurring keratocystic odontogenic tumor (KCOT). How to cite this article Swain N, Patel S, Poonja LS, Pathak J, Dekate K. Orthokeratinized Odontogenic Cyst. J Contemp Dent 2012;2(2):31-33.

scholarly journals A Rare Odontogenic Cyst in an Uncommon Area: Case Report and Review of the Literature

2021 ◽  
Vol 41 (01) ◽  
pp. 083-086
Author(s):  
Samira Behrad ◽  
Isa Safari ◽  
Shabnam Sohanian ◽  
Arash Ghanbarzadegan
Keyword(s):  
Case Report ◽  
Panoramic Radiography ◽  
Histopathological Examination ◽  
Anterior Part ◽  
Odontogenic Cyst ◽  
Odontogenic Tumor ◽  
Keratocystic Odontogenic Tumor ◽  
Review Of The Literature ◽  
Orthokeratinized Odontogenic Cyst ◽  
The Right

Abstract Objective Orthokeratinized odontogenic cyst is a rare developmental odontogenic cyst of the jaws. It is a less aggressive intraosseous cyst identified by an orthokeratinized epithelium. Case Report A 50-year-old male patient with the chief complaint of swelling in the anterior part of his face, and, intraorally, there was diffuse swelling in the palatal cortex. On panoramic radiography, there was a well-defined unilocular radiolucency on the right side of the maxilla and palatal cortical expansion, and thinning of the buccal and palatal cortexes was observed. The histopathological examination revealed a pathologic cyst that was lined by a thick orthokeratinized epithelium. Therefore, the diagnosis was orthokeratinized odontogenic cyst. Conclusion The orthokeratinized odontogenic cyst displays characteristic clinical, histopathological, and biological features that differ significantly from those of keratocystic odontogenic tumor (KCOT), but it has a better prognosis and lower recurrence rate. Thus, other radiolucent lesions of the jaws, including keratocystic odontogenic tumor (KCOT), must be considered in the differential diagnosis.

Immunohistochemical Analysis of GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Vitiliginous Skin Lesions

2015 ◽  
Vol 20 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Mohamed A. Adly ◽  
Hanan A. Assaf ◽  
Shaima’a F. Abdel-Rady ◽  
Nagwa Sayed Ahmed ◽  
Mahmoud Rezk Abdelwahed Hussein
Keyword(s):  
Protein Expression ◽  
Basal Cell ◽  
Cell Layer ◽  
Expression Patterns ◽  
Granular Cell ◽  
Epidermal Keratinocytes ◽  
Healthy Skin ◽  
Granular Cell Layer ◽  
Cognate Receptor ◽  
Spinous Layer

Background: Vitiligo is an idiopathic skin disease, characterized by circumscribed white macules or patches on the skin due to loss of the functional melanocytes. Glial cell line–derived neurotrophic factor (GDNF) and its cognate receptor (GFRα-1) are distal members of the transforming growth factor-β superfamily. GDNF, produced by the basal cell keratinocytes, is involved in the migration and differentiation of the melanocytes from the neural crest to the epidermis. This study examines the hypothesis that expression of GDNF protein and its cognate receptor GFRα-1 protein is altered in vitiliginous skin. Patients and Methods: To test our hypothesis, we examined the expression patterns of these proteins in vitiliginous and corresponding healthy (control) skin biopsies (20 specimens each) using immunoperoxidase staining techniques. Results: We found variations between the vitiliginous skin and healthy skin. In healthy skin, the expression of GDNF and GFRα-1 proteins was strong (basal cell keratinocytes and melanocytes), moderate (spinous layer), and weak (granular cell layer). In contrast, weak expression of GDNF protein was observed in all epidermal layers of vitiliginous skin. GFRα-1 protein expression was strong (basal cell keratinocytes and melanocytes), moderate (spinous layer), and weak (granular cell layer). In both healthy skin and vitiliginous skin, the expression of GDNF and GFRα-1 proteins was strong in the adnexal structures. Conclusions: We report, for the first time, decreased expression of GDNF proteins in the epidermal keratinocytes of vitiliginous skin. Our findings suggest possible pathogenetic roles for these proteins in the development of vitiligo. The clinical ramifications of these observations mandate further investigations.

Orthokeratinized Odontogenic Cyst: A Clinicopathologic Study of 61 Cases

2010 ◽  
Vol 134 (2) ◽  
pp. 271-275 ◽  
Author(s):  
Qing Dong ◽  
Shuang Pan ◽  
Li-Sha Sun ◽  
Tie-Jun Li
Keyword(s):  
Odontogenic Cyst ◽  
World Health ◽  
Keratocystic Odontogenic Tumor ◽  
Impacted Tooth ◽  
Ki 67 ◽  
Orthokeratinized Odontogenic Cyst ◽  
Clinicopathologic Study ◽  
Mandibular Molar ◽  
Health Organization

Abstract Context.—Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic keratocysts. Odontogenic keratocyst was designated as keratocystic odontogenic tumor (KCOT) in the new World Health Organization classification and OOC should be distinguished from KCOT for differences in histologic features and biologic behavior. Objective.—To analyze the clinicopathologic features of 61 cases of OOC in a Chinese population. Design.—Clinicopathologic analysis was performed on 61 cases of OOC. Immunohistochemical expression of Ki-67 and p63 was evaluated in 15 OOCs and 15 typical KCOTs. Results.—The 61 patients with OOC ranged from 13 to 75 years (average, 38.93 years). The lesions developed mainly in the third and fourth decades (57.38%) with a distinct predilection for males (72.13%). Six (9.84%) lesions were found in the maxilla and 55 (90.16%) in the mandible. The most common sites were in the mandibular molar and ramus region. Of the 54 cases with radiographic record, 47 (87.04%) were unilocular and 7 (12.96%) were multilocular radiolucencies. Twenty-seven of the 54 cysts were associated with an impacted tooth. Follow-up of 42 patients revealed no recurrence during an average period of 76.8 months after surgery. Compared with KCOTs, expression level of Ki-67 and p63 was significantly lower in OOCs, suggesting a lower proliferative activity. Conclusion.—Orthokeratinized odontogenic cyst is clinicopathologically distinct from KCOT and should constitute its own clinical entity.

Transcriptome differentiation along the dorso–ventral axis in laser-captured microdissected rat hippocampal granular cell layer

Neuroscience ◽  
2010 ◽  
Vol 170 (3) ◽  
pp. 731-741 ◽  
Author(s):  
T. Christensen ◽  
C.F. Bisgaard ◽  
H.B. Nielsen ◽  
O. Wiborg
Keyword(s):  
Cell Layer ◽  
Granular Cell ◽  
Granular Cell Layer

Odontogenic Keratocyst in a 9-Month-Old Patient: A Case Report

2021 ◽  
Vol 45 (3) ◽  
pp. 199-203
Author(s):  
Flávia Sirotheau Correa Pontes ◽  
Lucas Lacerda de Souza ◽  
Luiza Teixeira Bittencourt de Oliveira ◽  
Waqas Khan ◽  
Michelle Carvalho de Abreu ◽  
...  
Keyword(s):  
Case Report ◽  
Female Patient ◽  
Clinicopathological Characteristics ◽  
Odontogenic Cyst ◽  
Odontogenic Keratocyst ◽  
Basal Cells ◽  
Dental Lamina

Odontogenic Keratocyst (OKC) is a benign, intraosseous, odontogenic cyst which originates from the basal cells of overlying epithelium or from the dental lamina remnants. Clinically, they are presented as asymptomatic swellings, although can sometimes be associated with pain. Growth of an OKC leads to expansion and destruction of bone as it infiltrates the tissue around it. It is commonly seen in males between the second and fourth decades of life. The aim of this study is to report on the clinicopathological characteristics of an odontogenic keratocyst in a 9-month-old female patient and posterior rehabilitation with a removable maxillary expander.

scholarly journals Aggressive Orthokeratinized Odontogenic Cyst: A Rare Case Report and Review

2015 ◽  
Vol 6 (2) ◽  
pp. 40-43 ◽  
Author(s):  
Subhadeep Sarkar ◽  
Obaid Khursheed ◽  
Ruby Bansal ◽  
Waseem K Burza
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Odontogenic Cyst ◽  
Orthokeratinized Odontogenic Cyst ◽  
Rare Case Report

ORTHOKERATINIZED ODONTOGENIC CYST IN AN ADOLESCENT: A CASE REPORT

2020 ◽  
Vol 129 (1) ◽  
pp. e49
Author(s):  
GEORGIA RIBEIRO MARTINI ◽  
BUBACAR EMBALÓ ◽  
JUSSARA MARIA GONÇALVES ◽  
PRISCILA SELL ◽  
EDUARDO MEURER ◽  
...  
Keyword(s):  
Case Report ◽  
Odontogenic Cyst ◽  
Orthokeratinized Odontogenic Cyst
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