The objective of this research consists of the design, construction and automation of the electrospinning mechatronic system to obtain nanofibers. As a first stage, the structure of the electrospinning mechatronic system and the distribution, injection and manifold system were designed and built. In the second stage, the open-loop control system was outlined and implemented. It is made up of: control, isolation stage, and the plant. In the first element, the LabView interface and ATMega2560 microcontroller were used to manipulate the variables of the injection speed and distribution of the solution, the speed of the nanofiber collector and the height between the capillary tube and the collector, the magnitude of the temperature and humidity from the environment, also, the graphic interface was developed, the second element consists of isolating the control and power stage in addition to amplifying the command signals and enabling the correction elements, the third element receiving the signals from the power stage to perform the action and produce a change in the controlled variables in the process. With this prototype, it is intended to obtain nanofibers from different polymer solutions for use in the area of catalysis and biomaterials.