Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data

It is well-accepted that both environment and genetic factors contribute to the development of mental disorders (MD). However, few genetic studies used time-to-event data analysis to identify the susceptibility genetic variants associated with MD and explore the role of environment factors in these associations. In order to detect novel genetic loci associated with MD based on the time-to-event data and identify the role of environmental factors in them, this study recruited 376,806 participants from the UK Biobank cohort. The MD outcomes (including overall MD status, anxiety, depression and substance use disorders (SUD)) were defined based on in-patient hospital, self-reported and death registry data collected in the UK Biobank. SPACOX approach was used to identify the susceptibility loci for MD using the time-to-event data of the UK Biobank cohort. And then we estimated the associations between identified candidate loci, fourteen environment factors and MD through a phenome-wide association study and mediation analysis. SPACOX identified multiple candidate loci for overall MD status, depression and SUD, such as rs139813674 (P value = 8.39 × 10–9, ZNF684) for overall MD status, rs7231178 (DCC, P value = 2.11 × 10–9) for depression, and rs10228494 (FOXP2, P value = 6.58 × 10–10) for SUD. Multiple environment factors could influence the associations between identified loci and MD, such as confide in others and felt hated. Our study identified novel candidate loci for MD, highlighting the strength of time-to-event data based genetic association studies. We also observed that multiple environment factors could influence the association between susceptibility loci and MD.

Digitalization and Information Management Mechanism of Sports Events Based on Multisensor Node Cooperative Perception Model

In the process of developing major sports events, how to guide providers and users to provide and utilize the archives information resources of major sports events and realize the interaction between them is an important problem to be solved urgently in the development of major sports events and the archive service of major sports events. By analyzing the present situation of archive service of major sports events, especially the analysis of the opposite dependent subjects of service providers and users, we can see that the continuous development of archive services for major sports events will inevitably lead to constant changes in user groups and user needs, guided by the theory of information retrieval, knowledge management, and media effect. According to the service model of archive service of major sports events, the archive service model of specific sports events is constructed. In this paper, four kinds of event recommendation models are applied to the collected marathon event data for experiments. Through experimental comparison, the effectiveness of content-based recommendation algorithm technology in the event network data set is verified, and an algorithm model suitable for marathon event recommendation is obtained. Experiments show that the comprehensive event recommendation model based on term frequency–inverse document frequency (TF-IDF) text weight and Race2vec entry sequence has the best recommendation performance on marathon event data set. According to the recommendation target of the event and the characteristics of the event data type, we can choose a single or comprehensive recommendation algorithm to build a model to realize the event recommendation.

Estimating a time-to-event distribution from right-truncated data in an epidemic: A review of methods

Time-to-event data are right-truncated if only individuals who have experienced the event by a certain time can be included in the sample. For example, we may be interested in estimating the distribution of time from onset of disease symptoms to death and only have data on individuals who have died. This may be the case, for example, at the beginning of an epidemic. Right truncation causes the distribution of times to event in the sample to be biased towards shorter times compared to the population distribution, and appropriate statistical methods should be used to account for this bias. This article is a review of such methods, particularly in the context of an infectious disease epidemic, like COVID-19. We consider methods for estimating the marginal time-to-event distribution, and compare their efficiencies. (Non-)identifiability of the distribution is an important issue with right-truncated data, particularly at the beginning of an epidemic, and this is discussed in detail. We also review methods for estimating the effects of covariates on the time to event. An illustration of the application of many of these methods is provided, using data on individuals who had died with coronavirus disease by 5 April 2020.

Human Rights Violations in Space: Assessing the External Validity of Machine-Geocoded versus Human-Geocoded Data

Political event data are widely used in studies of political violence. Recent years have seen notable advances in the automated coding of political event data from international news sources. Yet, the validity of machine-coded event data remains disputed, especially in the context of event geolocation. We analyze the frequencies of human- and machine-geocoded event data agreement in relation to an independent (ground truth) source. The events are human rights violations in Colombia. We perform our evaluation for a key, 8-year period of the Colombian conflict and in three 2-year subperiods as well as for a selected set of (non)journalistically remote municipalities. As a complement to this analysis, we estimate spatial probit models based on the three datasets. These models assume Gaussian Markov Random Field error processes; they are constructed using a stochastic partial differential equation and estimated with integrated nested Laplacian approximation. The estimated models tell us whether the three datasets produce comparable predictions, underreport events in relation to the same covariates, and have similar patterns of prediction error. Together the two analyses show that, for this subnational conflict, the machine- and human-geocoded datasets are comparable in terms of external validity but, according to the geostatistical models, produce prediction errors that differ in important respects.