Hemodynamic And Morphological Changes of The Central Retinal Artery In Myopic Eyes

Due to excessive elongation of the eyeball, myopia-related vascular abnormalities are frequently observed in the central retinal artery (CRA) and its intraretinal branches. In addition to inconsistency in previously reported findings, hemodynamic (reduced flow velocity, increased vascular resistance) and morphological changes (narrower vessel diameter) were usually studied separately. This cross-sectional study evaluated the hemodynamic and morphological characteristics concurrently in a large sample of healthy myopes, by using the color Doppler ultrasound and adaptive optics retinal camera. Results showed that the retrobulbar segment of CRA had a tendency of slightly reduced flow velocity in eyeballs with longer axial length, but the correlation was not significant after adjusting for the multiple correlations. Vascular resistance was not affected by the axial elongation. With respect to the intraretinal branches, no significant changes in longer eyes of total diameter or lumen diameter were observed , while both the wall thickness and the wall cross-sectional area were significantly increased, but only a marginally increase in the wall to lumen ratio was found with increasing axial length. This implies some potential small artery remodeling in the intraretinal CRA branches. Overall, blood supply of the inner retina in healthy young myopes is likely to be maintained. Additionally, morphological parameters of vascular microstructure could be potential biomarkers to monitor myopia progression and understand myopia-related vascular abnormalities in future studies.

Numerical Simulation and Modelling Convention of Unsteady Fluidelastic Forces of Tube Arrays

This paper presents a numerical investigation on the unsteady fluidelastic forces of tube arrays. The key focus is on the consistency between the unsteady fluidelastic force model and the quasi-steady model for tube arrays at large reduced flow velocities, as well as comparing two well-known conventions for the unsteady model. Two-dimensional unsteady Reynolds-averaged Navier-Stokes (URANS) simulations are used to prove that the viscous damping coefficients of Tanaka's convention (Tanaka and Takahara, 1981) approach their quasi-steady values as the reduced flow velocity approaches infinity, whereas the hysteretic damping coefficients of Chen's modified convention (Chen et al., 1983) always approach zero and hence result in low-resolution data plots as the reduced flow velocity becomes large. The non-constant viscous damping coefficients of Tanaka's experimental data at high reduced flow velocities (which motivated the introduction of Chen's modified convention) might be induced by a systematic identification error in the phase of the fluidelastic force. A row of three flexible cylinders is used as a numerical example to analyse the effect of systematic phase error on the predicted stability boundary of the fluidelastic instability. Although identical fluidelastic forces are simulated by using the two conventions, Tanaka's convention is recommended due to its compatibility with the quasi-steady theory and optimal resolutions of data plots over any range of reduced flow velocities.

Incidence of left atrial appendage thrombus on pre-procedural TOE before catheter ablation of atrial tachyarrhythmias

Introduction Transoesophageal echocardiography (TOE) is routinely performed before catheter ablation of atrial tachyarrhythmias to rule out the presence of possible left atrial thrombi. However, data to support this practice are scarce. Methods We analysed consecutive pre-procedural TOE in a high-volume electrophysiology centre for the presence of left atrial thrombi and a relevant flow reduction in the left atrial appendage (LAA) defined as LAA sludge or pronounced spontaneous echo contrast. Possible predictors of reduced flow were recorded and compared in a multivariate logistic regression analysis. Results 1676 consecutive TOE were included (1122 before pulmonary vein isolation (PVI), 436 before atrial flutter ablation, 166 before other EP studies in patients with a history of atrial tachyarrhythmias). 543 patients (32%) were female, mean age was 63±12 years and BMI was 27±5 kg/m2. Nine patients (0.5%) had an LAA thrombus on pre-procedural TOE. Ninety-five further patients (5.7%) had a relevant reduction in LAA flow as characterized by LAA sludge or spontaneous echo contrast. Further patient characteristics by LAA flow state are shown in the table. While a higher CHA2DS2-VaSc-Score was associated with the presence of LAA sludge and LAA thrombus (p=0.01), no further clinical parameters such as choice of oral anticoagulation agent were independently predictive of reduced flow velocities or thrombus in a logistic regression model (see table). Importantly, LAA thrombi also occurred in patients with a CHA2DS2-VaSc-Score ≤1 (n=1) or in sinus rhythm (n=2). Of note, 6 out of 9 patients with a LAA thrombus were anticoagulated with phenprocoumon. Conclusion LAA thrombus is a rare occurrence before an elective catheter ablation. In patients with CHA2DS2-VaSc-Score ≤1 the likelihood of LAA thrombus is so low (0.2%) that it may be considered to give up routine TOE before an EP study/ablation. FUNDunding Acknowledgement Type of funding sources: None.

Measurements to Quantify the Effect of a Reduced Flow Rate On the Performance of a Tilting Pad Journal Bearing (LBP) with Flooded Ends

Operation of tilting pad journal bearings (TPJBs) with a reduced flow improves system energy efficiency by reducing drag power losses, albeit the temperature rise in both the bearing pads and the lubricating oil become a concern. This paper presents measurements of the static and dynamic load performance of a flooded ends TPJB with flowrates ranging from 150% to ~5% of a nominal supply condition. The test bearing is a four-pad, 102 mm diameter, center pivot, with single orifice feeds, and configured with end seals. Experiments include operation at two shaft speeds = 6 krpm and 12 krpm and under three specific loads = 0.345 MPa, 1.03 MPa and 2.07 MPa applied in between pads (LBP). The measurements show the bearing drag power loss decreases by nearly 20% when flow rate drops to 50% of nominal. However, halving the flow produces a raise in pad subsurface temperatures, ~7 °C for operation at 12 krpm. Flow reduction below 50% results in substantial power savings; however, it also produces too hot pad temperatures that approach a known limit for Babbitt material safe operation. Damping coefficients decrease by ~30% as the flow rate decreases from 150% to just a few % of nominal flow. The experimental results are first to quantify operation of a TPJB supplied with minute amounts of lubricant flow. A test with a very low flow rate at ~2% of nominal and under a light load produced the emergence of a broadband subsynchronous vibration frequency, albeit with very small amplitude.

A Model for Tilting Pad Thrust Bearings Operating with Reduced Flow Rate ? Do Benefits Outweigh Risks?

This paper implements a model into an existing thermo-elasto-hydrodynamic (TEHD) computational analysis tool to deliver load performance predictions for TPTBs operating with reduced flow rates. For bearings supplied with either a reduced flow or an over flow conditions, a sound model for the flow and thermal energy mixing in a feed groove determines the temperature of the lubricant entering a thrust pad. Under a reduced flow condition, the analysis reduces the effective arc length of a wetted pad until matching the available flow. Predicted discharge flow temperature rise and pad subsurface temperature rise from the present model match measurements in the archival literature for an eight-pad bearing supplied with 150% to 25% of the nominal flow rate, i.e., the minimum flow that fully lubricates the bearing pads. A supply flow above nominal rate increases the bearing drag power because the lubricant enters a pad at a lower temperature, and yet has little effect on a thrust pad peak temperature rise or its minimum film thickness. A reduced flow below nominal produces areas lubricant starvation zones, and thus the minimum film thickness substantially decreases while the film and pad's surface temperature rapidly increase to produce significant thermal crowning of the pad surface. A reduction in drag power with less lubricant supplied brings an immediate energy efficiency improvement to bearing operation. However, sustained long-term operation with overly warm pad temperatures could reduce the reliability of the mechanical element and its ultimate failure.

Derivation of a Closed Form Expression for Estimating the Reduced Flow Rate for Pressure Driven Rarefied Gas Flow Through Circular Nano/Micro Pores

In this paper, a new model to predict the gas flow rate through short tubes under rarefied condition based on the sigmoidal bahaviour of gas reduced flow rate (W) versus the rarefaction parameter (d) under rarefied condition was developed. The data produced by Varoutis et al. via Direct Simulation Monte Carlo (DSMC) method were utilised to obtain the model coefficients as functions of tube length to radius (w) and pressure ratio (Pr). Then, the model was tested against the published experimental data.There was a high degree of agreement between the model predictions and the experimental data. Moreover, the new model was capable to predict the reduced flow rate of rarefied systems, not only at free molecular region and hydrodynamic region, but also at transition region, hence covering all the Knudsen number domain within the utilised data. Therefore, the proposed model was capable to make predictions as well as meet all the criteria of the rarefied gas flow within the following conditions: 0<Pr<0.9, 0.01<d<1000 and 0.0<w<20. Thus, the proposed model provides a useful tool to make a valid prediction of the rarefied gas flow behavior in a wide range of gas transport regime.

A Model for Tilting Pad Thrust Bearings Operating With Reduced Flow Rate – Do Benefits Outweigh Risks?

The literature on tilting pad thrust bearings (TPTB) calls for flow reduction as an effective means to reduce drag power losses as well as oil pumping costs. However, the highest level of flow reduction a bearing can undergo while maintaining reliable operation is a key question that demands comprehensive analysis. This paper implements a model into an existing thermoelasto-hydrodynamic (TEHD) computational analysis tool to deliver load performance predictions for TPTBs operating with reduced flow rates. For bearings supplied with either a reduced flow or an over flow conditions, a sound model for the flow and thermal energy mixing in a feed groove determines the temperature of the lubricant entering a thrust pad. Under a reduced flow condition, the analysis reduces the effective arc length of a wetted pad until matching the available flow. Predicted discharge flow temperature rise and pad subsurface temperature rise from the present model match measurements in the archival literature for an eight-pad bearing supplied with 150% to 25% of the nominal flow rate, i.e., the minimum flow that fully lubricates the bearing pads. A supply flow above nominal rate increases the bearing drag power because the lubricant enters a pad at a lower temperature, and yet has little effect on a thrust pad peak temperature rise or its minimum film thickness. A reduced flow below nominal produces areas lubricant starvation zones, and thus the minimum film thickness substantially decreases while the film and pad’s surface temperature rapidly increase to produce significant thermal crowning of the pad surface. Compared to the bearing lubricated with a nominal rate, a starved flow bearing produces a larger axial stiffness and a lesser damping coefficient. A reduction in drag power with less lubricant supplied brings an immediate energy efficiency improvement to bearing operation. However, sustained long-term operation with overly warm pad temperatures could reduce the reliability of the mechanical element and its ultimate failure.