The current evaluation method does not consider the coordination and overall situation of various practical skills, which affects the evaluation contact degree and leads to hidden dangers of production safety. Therefore, an evaluation method of chemical technology safety practical operation ability based on a stochastic model is proposed. Using association rules to design the feature mining algorithm of practical operation ability, combined with crosslayer coding strategy, the mapping relationship between safety accidents and practical operation ability is established. The chemical safety practical operation skills are simulated by a random model, and the practical operation skills are classified and coordinated according to the simulation predictive control results. According to the coordination results, the evaluation index system is constructed, the index weight is determined, and the evaluation model of chemical technology safety operation ability is constructed. The experimental results show that the maximum connection degree of the evaluation method designed in this paper is 88.06%, and the evaluation results are more accurate, which is helpful to improve the production safety of chemical enterprises.