Dissemination of the Independent Family Health Evaluation (IFHE) application in creating a healthy village in Tutul Village, Balung District

The empowerment of village community health is crucial to improve, one of which is by increasing family-based human resources. The ability to recognize the condition of the family's health status at an early stage can speed up the process of assisting health services based on the problems at hand, which can be accelerated with the Independent Family Health Evaluation (IFHE) application system. The dissemination of IFHE was carried out on August 9, 2021 in Tutul Healthy Village task force group, attended by 47 participants from the Community Association (RW) and Posyandu using the direct practice method. Later on, this group continued to disseminate information to the community through trial 1 and trial 2, each of which was held on 11-13 August 2021 for 400 families. From the dissemination program resulted that 319 families had no health risks, 64 families had a low risk, 10 families had a moderate risk and 7 families had a high risk. The IFHE application is very beneficial in quickly identifying the family health status. It is recommended that families routinely report their family's health status through the IFHE, so that the healthcare workers can use the information in making decisions to improve public health

Asproinocybaceae fam. nov. (Agaricales, Agaricomycetes) for Accommodating the Genera Asproinocybe and Tricholosporum, and Description of Asproinocybe sinensis and Tricholosporum guangxiense sp. nov

Asproinocybe and Tricholosporum are not well known, and their placement at the family level remains undetermined. In this study, we conducted molecular phylogenetic analyses based on nuc rDNA internal transcribed spacer region (ITS) and nuc 28S rDNA (nrLSU), and a dataset with six molecular markers (ITS, LSU, RNA polymerase II largest subunit (RPB1), RNA polymerase II second largest subunit (RPB2), 18S nuclear small subunit ribosomal DNA (nrSSU), and translation elongation factor 1-alpha (TEF1-α)) using Bayesian (BA) and Maximum Likelihood (ML) methods, we found that the species of Asproinocybe and Tricholosporum formed an independent family-level clade (0.98/72). Asproinocybaceae fam. nov., a new family, is established here for accommodating this clade. Two new species, Asproinocybe sinensis and Tricholosporum guangxiense, from subtropical and tropical karst areas of China, are also described here.

Co-Occurrence of Fragile X Syndrome with a Second Genetic Condition: Three Independent Cases of Double Diagnosis

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and autism caused by the instability of a CGG trinucleotide repeat in exon 1 of the FMR1 gene. The co-occurrence of FXS with other genetic disorders has only been occasionally reported. Here, we describe three independent cases of FXS co-segregation with three different genetic conditions, consisting of Duchenne muscular dystrophy (DMD), PPP2R5D--related neurodevelopmental disorder, and 2p25.3 deletion. The co-occurrence of DMD and FXS has been reported only once in a young boy, while in an independent family two affected boys were described, the elder diagnosed with FXS and the younger with DMD. This represents the second case in which both conditions coexist in a 5-year-old boy, inherited from his heterozygous mother. The next double diagnosis had never been reported before: through exome sequencing, a girl with FXS who was of 7 years of age with macrocephaly and severe psychomotor delay was found to carry a de novo variant in the PPP2R5D gene. Finally, a maternally inherited 2p25.3 deletion associated with a decreased level of the MYT1L transcript, only in the patient, was observed in a 33-year-old FXS male with severe seizures compared to his mother and two sex- and age-matched controls. All of these patients represent very rare instances of genetic conditions with clinical features that can be modified by FXS and vice versa.

Re-description of the Cretaceous wasp Humiryssus leucus Lin, 1980 (Hymenoptera: Evanioidea: Baissidae)

Humiryssus Lin, 1980 is a Cretaceous genus with Humiryssus leucus Lin, 1980 as its type species established based on a tiny wasp from the Lower Cretaceous (Hauterivian-Barremian) Laocun Formation at Laocun, Jiande, Zhejiang Province, eastern China and originally placed in the extinct family Paroryssidae (Hymenoptera: Tenthredinoidea) (Lin, 1980). It was later treated jointly with the genus Manlaya Rasnitsyn, 1980 (Evanioidea: Gasteruptiidae: Baissinae) because the characters shown in the line drawing by Lin (1980) indicate a close relationship of the genus to Manlaya (Rasnitsyn et al., 1998). However, Zhang & Rasnitsyn (2004) considered it to be a separate genus within the Baissinae, which is now considered as an independent family under the Evanioidea (e.g., Li et al., 2018; Jouault et al., 2020, 2021).

Identification of Distant Regulatory Elements Using Expression Quantitative Trait Loci Mapping for Heat-Responsive Genes in Oysters

Many marine ectotherms, especially those inhabiting highly variable intertidal zones, develop high phenotypic plasticity in response to rapid climate change by modulating gene expression levels. Herein, we examined the regulatory architecture of heat-responsive gene expression plasticity in oysters using expression quantitative trait loci (eQTL) analysis. Using a backcross family of Crassostrea gigas and its sister species Crassostrea angulata under acute stress, 56 distant regulatory regions accounting for 6–26.6% of the gene expression variation were identified for 19 heat-responsive genes. In total, 831 genes and 164 single nucleotide polymorphisms (SNPs) that could potentially regulate expression of the target genes were screened in the eQTL region. The association between three SNPs and the corresponding target genes was verified in an independent family. Specifically, Marker13973 was identified for heat shock protein (HSP) family A member 9 (HspA9). Ribosomal protein L10a (RPL10A) was detected approximately 2 kb downstream of the distant regulatory SNP. Further, Marker14346-48 and Marker14346-85 were in complete linkage disequilibrium and identified for autophagy-related gene 7 (ATG7). Nuclear respiratory factor 1 (NRF1) was detected approximately 3 kb upstream of the two SNPs. These results suggested regulatory relationships between RPL10A and HSPA9 and between NRF1 and ATG7. Our findings indicate that distant regulatory mutations play an important role in the regulation of gene expression plasticity by altering upstream regulatory factors in response to heat stress. The identified eQTLs provide candidate biomarkers for predicting the persistence of oysters under future climate change scenarios.

Pengelolaan Keuangan Keluarga Dan Pengenalan Dasar-Dasar Investasi Menuju Keluarga Mandiri Bagi Ibu-Ibu Majlis Taklim Al Auladiyah Di Kelurahan Bakti Jaya Kecamatan Setu Tangerang Selatan

Pengabdian Kepada Masyarakat (PKM) which is called Community Service Activities was held from 6-8 July 2020 as a form to fulfilling the obligations of the higher education of Tri Dharma at Pamulang University. The purpose of this PKM is to Introduce Fundamental Investment and Financial Management Towards Independent Family For Majelis Taklim Al Auladiyah in Tangerang Selatan. Financial management for the family is needed so, therefore, all family needs such as food, clothes, shelter, school fee, or desire to buy a new motorbike/car can be fulfilled. First things first are getting to know your financial condition, and determine your needs not to wants, and choose top priority, the family has to prepare a household budget for current and future needs avoids unnecessary desires, and don’t “Big Pegs than the Pole” neither. One of the stages of financial family planning is preparing a household budget to prevent financial failure in the household. The result or output of this activity is to increase knowledge of the importance of understanding, financial arrangements, improve family welfare to avoid dependence on borrowing money from creditors.

The impact of the fipronil crisis on the financial performance of Dutch laying hen farms

Background Illegal use of fipronil as an insecticide in 2017 has caused substantial damage to Dutch laying hen farms. We assessed how the fipronil crisis has affected the financial performance of affected farms as well as unaffected farms. While affected farms faced culling their flocks and lost revenue, unaffected farms benefitted from temporary high egg prices. Methods A three-step normative modelling approach is taken using financial statements and a partial budget. The estimations are for a 50,000 laying hen farm facing the fipronil crisis for 5 months. First, a baseline is created by generating an income statement of this laying hen farm representing a ‘normal year’. Second, incremental costs and revenue as a result of the fipronil crisis are estimated. Third, the baseline income statement is updated with the outcomes of the partial budget. This results in two additional income statements that report the net operating result of this farm being unaffected and affected by the fipronil crisis. Results While in a normal year this average-sized farm has a net operating result of around 18,000 euros, profitability was estimated to be − 369,000 euros and + 169,000 euros for the affected and unaffected farm due to the crisis respectively. For affected farms, impacts were especially high as there was no government compensation or insurance. Conclusions As Dutch farms typically operate as independent family farms, there was also no compensation from other chain actors. The affected farms therefore likely have faced financial distress and have had to increase debt or use their financial reserves for household consumption and restarting the business. Outcomes contribute to discussions around liability claims and cost-benefit assessments of measures to improve the chain food safety and rapid alert systems.

The impact of the fipronil crisis on the financial performance of Dutch laying hen farms

Background: Illegal use of fipronil as an insecticide in 2017 has caused substantial damage to Dutch laying hen farms. We assessed how the fipronil crisis has affected the financial performance of affected farms as well as unaffected farms. While affected farms faced culling their flocks and lost revenue, unaffected farms benefitted from temporary high egg prices.Methods: A three-step normative modelling approach is taken using financial statements and a partial budget. The estimations are for a 50 000 laying hen farm facing the fipronil crisis for five months. First, a baseline is created by generating an income statement of this laying hen farm representing a ‘normal year’. Second, incremental costs and revenue as a result of the fipronil crisis are estimated. Third, the baseline income statement is updated with the outcomes of the partial budget. This result in two additional income statements that report the net operating result of this farm being unaffected and affected by the fipronil crisis. Results: While in a normal year this average-sized farm has a net operating result of around 18k euro, profitability was estimated to be -369k euro and +169k euro for the affected and unaffected farm due to the crisis respectively. For affected farms, impacts were especially high as there was no government compensation or insurance. Conclusions: As Dutch farms typically operate as independent family farms, there was also no compensation from other chain actors. The affected farms therefore likely have faced financial distress and have had to increase debt or use their financial reserves for household consumption and restarting the business. Outcomes contribute to discussions around liability claims and cost-benefit assessments of measures to improve chain food safety and rapid alert systems.