Smart grid technology is the key for a reliable and efficient use of distributed energy resources. Amongst all the renewable sources, solar power takes the prominent position due to its availability in abundance. In this chapter, the authors present smart grid infrastructure issues and integrating solar PV-sourced electricity in the smart grid. Smart grid has many features, including reliability, flexibility on network topology, efficiency, sustainability, and market-enabling. The authors select a photovoltaic active power line conditioner as a case study. This line conditioner is a device designed to extract the maximum power of a photovoltaic (PV) system and to compensate the nonlinear and unbalanced loads of the electrical power systems. The performance of the PV conditioner with the neuro-fuzzy control designed has been analyzed through a simulation platform.