Introduction: A common problem in image restoration is image denoising. Among many noise models, the mixed Poisson-Gaussian model has recently aroused considerable interest. Purpose: Development of a model for denoising images corrupted by mixed Poisson-Gaussian noise, along with an algorithm for solving the resulting minimization problem. Results: We proposed a new total variation model for restoring an image with mixed Poisson-Gaussian noise, based on second-order total generalized variation. In order to solve this problem, an efficient alternating minimization algorithm is used. To illustrate its comparison with related methods, experimental results are presented, demonstrating the high efficiency of the proposed approach. Practical relevance: The proposed model allows you to remove mixed Poisson-Gaussian noise in digital images, preserving the edges. The presented numerical results demonstrate the competitive features of the proposed model.