The grille-type steel plate concrete composite wall (GSPCW) is an innovative shear wall system that mainly consists of steel faceplates, steel tie plates and infilled concrete. Compared to traditional steel plate concrete composite shear walls, the advantages of GSPCW walls include: (1) relatively high lateral and buckling resistance; and (2) simple structural measures for convenient construction and implementation. This paper presents the results of extensive numerical investigations regarding GSPCW systems, examining both GSPCW wall components and their application in a super-high-rise building as a case study. First, typical GSPCW wall models are established using DIANA software, and the numerical models are validated on the basis of comparison with results from previously reported experimental tests. The verified models are further used to perform parametric analyses with the aim of further understanding the effects of various design parameters on the seismic performance of GSPCW systems, including steel ratio, axial load ratio, height-to-width ratio, aspect ratio of the grille steel plate, and concrete compressive strength. Second, a super-high-rise building was selected for application to perform a case study of a GSPCW system. The seismic performance of the tall building in the case study was comparatively evaluated on the basis of both nonlinear time history analysis and modal pushover analysis (MPA), and the results from both of these methods validated the use of GSPCW is an efficient structural wall system appropriate for use in super-high-rise buildings. Finally, a simple economic assessment of the GSPCW building was performed, and the results were compared with those obtained for conventional reinforced concrete wall buildings.