The Novel Multi-layered Approach to Enhance Sorting Performance of Healthcare Analysis

Emergence of big data in today’s world leads to new challenges for sorting strategies to analyze the data in a better way. For most of the analyzing technique, sorting is considered as an implicit attribute of the technique used. The availability of huge data has changed the way data is analyzed across industries. Healthcare is one of the notable areas where data analytics is making big changes. An efficient analysis has the potential to reduce costs of treatment and improve the quality of life in general. Healthcare industries are collecting massive amounts of data and look for the best strategies to use these numbers. This research proposes a novel non-comparison based approach to sort a large data that can further be utilized by any big data analytical technique for various analyses.

Pengaruh Kecukupan Modal, Risiko Kredit t/erhadap Profitabilitas dengan Efisiensi sebagai Variabel Intervening

This study aims to determine whether there is an effect of Capital Adequacy Ratio (CAR), Non Performing Loan (NPL) on Profitability (ROA) with Efficiency (BOPO) as an Intervening Variable, in conventional commercial banks in Indonesia listed on the Indonesia Stock Exchange period (2016). -2020). Sampling using the purposive sampling method with the criteria that the bank has a complete published report in 2016-2020, and the bank has a non-negative ROA. This study uses data obtained from the bank's Annual Financial Statements issued by the bank in the Financial Services Authority (OJK) Bank Published Financial Statements. The analytical technique used is a statistical test through the Ttest, Ftest, R2, Multiple Regression Test, and Sobel Test using the Sobel Test Calculator for the Significance of Mediation. The results of the analysis on the t test show that CAR has a negative and insignificant effect on ROA, NPL has a negative and insignificant effect on ROA, BOPO has a negative and significant effect on ROA. CAR has a negative and significant effect on BOPO, NPL has no significant effect on BOPO. And the results of the Sobel test showed that BOPO was able to mediate the CAR variable on ROA but was unable to mediate the effect of NPL on ROA. Keywords: CAR; NPL; ROA; BOPO

Pengaruh Profitabilitas, Likuiditas, Ukuran Perusahaan Dan Keputusan Investasi Terhadap Nilai Perusahaan

Companies need funds to finance their operational activities, therefore a company must be able to attract investors to be interested in investing their capital. The high and low value of the company can be an attraction for investors. In addition to reflecting current conditions, company value can also describe the company's prospects in the future. Because it is important to do a research on what factors can have an influence on the value of the company. This study aims to analyze the effect of profitability, liquidity, firm size and investment decisions on firm value. The study was conducted on banks listed on the Indonesia Stock Exchange in 2018-2020, the sampling method used a purposive sampling technique. The analytical technique used is multiple linear regression analysis with the help of the SPSS program. The results of this study indicate that the variables of profitability, liquidity and investment decisions have a positive and significant effect on firm value. While the firm size variable has a negative and insignificant effect on firm value. Keywords: firm value, profitability, liquidity, firm size, investment decisions

Phytochemistry and Biological Activities of Amburana cearensis (Allemão) ACSm

Amburana cearensis (Allemão) ACSm. belongs to the Fabaceae family and occurs in the Brazilian semiarid, Argentina, Paraguay, Bolivia, and Peru. Numerous studies that portray its ethnobotany, use in popular medicine, chemical composition, and biological activities exist in the literature. This review aimed to provide an overview of the chemical composition, ethnopharmacology, and biological activities associated with A. cearensis and its isolated constituents. Information was collected from internet searches in the Scopus, Medline, PubMed, Google Scholar, and ScienceDirect databases were performed covering publications from 1997–2020. An ethnopharmacological literature analysis revealed that A. cearensis is used to treat a wide range of respiratory disorders in addition to intestinal, circulatory, and inflammatory problems. Coumarins, flavonoids, phenolic glycosides, phenolic acids, phenylpropanoid derivatives, and triterpenoids, among others, have been reported as active compounds, with High-Performance Liquid Chromatography (HPLC) being the main analytical technique used. The A. cearensis extracts and compounds presented several biological activities, including antimicrobial, antinociceptive, anti-inflammatory, antioxidant, neuroprotective, and myorelaxant activities, among others. This review provides a useful bibliography for future investigations and A. cearensis applications; however, future studies should focus on its toxic effects and the mechanisms of action of its extracts and isolated constituents to guide clinical applications.

Seeking elsewhere: a systematic review of literature surrounding attrition and retention of female architects in the profession post-registration

PurposeThe purpose of this study is to provide a global snapshot of the current state of knowledge regarding attrition rates of women architects. The intended audience includes all the stakeholders of the profession, as well as those interested in professional attrition studies, with the aim to contribute to a social debate, which places increasing value on diversity, equal representation and retention in this field.Design/methodology/approachThis paper has utilized the structured analytical technique of a systematic review of the scholarship involving scholarship published over two decades between the years 2000 and 2020. Having selected research on this topic following a series of exclusionary and inclusionary criteria for relevancy and accuracy, this select research has been categorically and thoroughly analyzed using this technique.FindingsThis literature review identifies four main recurring themes among the literature, which address this research question, including: (1). cross-national differences and similarities; (2) demotivating factors leading to attrition; (3) graduate/architect terminology, which blurs the distinction between participants in architecture; and (4) implications of female architects as represented in professional publications and the “reward system.” Consequently, this literature review finds that to date no singular cause can be pinpointed as the sole cause of women's attrition, but rather a series of complex and intertwining factors, some of them specific to the profession.Originality/valueThis paper suggests areas for further study into the reduction of attrition rates of registered women in this discipline, with an emphasis that further research may expand to focus rather on positive aspects of the profession resulting in areas of retention, which has been of little focus in current research. Additionally, these findings make suggestions toward a series of recommendations that may assist in framing the industry toward more positive and equitable career and industry trajectories.

Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues

Glycosylation is essential to brain development and function, but prior studies have often been limited to a single analytical technique and excluded region- and sex-specific analyses. Here, using several methodologies, we analyze Asn-linked and Ser/Thr/Tyr-linked protein glycosylation between brain regions and sexes in mice. Brain N-glycans are less complex in sequence and variety compared to other tissues, consisting predominantly of high-mannose and fucosylated/bisected structures. Most brain O-glycans are unbranched, sialylated O-GalNAc and O-mannose structures. A consistent pattern is observed between regions, and sex differences are minimal compared to those in plasma. Brain glycans correlate with RNA expression of their synthetic enzymes, and analysis of glycosylation genes in humans show a global downregulation in the brain compared to other tissues. We hypothesize that this restricted repertoire of protein glycans arises from their tight regulation in the brain. These results provide a roadmap for future studies of glycosylation in neurodevelopment and disease.

Commercial gigahertz-class NMR magnets

Nuclear Magnetic Resonance (NMR) spectroscopy is a wide-spread analytical technique which is used in a large range of different fields, such as quality control, food analysis, material science and structural biology. In the widest sense, NMR is an analytical technique to determine the structure of molecules. At the time of writing this manuscript, commercial NMR spectrometers with a proton resonance frequency ≥ 900 MHz are only available from Bruker. In 2019, Bruker installed the first 1.1 GHz (25.8 T) NMR spectrometer at the St. Jude Children Research Hospital in Memphis, Tennessee, followed by the installation of the first 1.2 GHz (28.2 T) NMR spectrometer at the University of Florence in Italy in 2020. These were the first commercial NMR spectrometers operating at magnetic fields in excess of what can be achieved with conventional low temperature superconductors, and which depend on high temperature superconductors to generate the required magnetic field. In this paper, the requirements on commercial NMR magnets are discussed and the history of high-field NMR magnets is reviewed. Bruker’s R&D program for 1.1 and 1.2 GHz NMR magnets and spectrometers will be described, and some of the key properties of these first commercial NMR magnets with high-temperature superconductors are reported.

Upaya Perlindungan Pesisir dan Pulau-Pulau Kecil Pemerintah Provinsi Sumatera Barat dari Ancaman Abrasi dan Perubahan Iklim

Kerusakan pesisir dan pulau-pulau kecil akibat abrasi dan dampak perubahan iklim di Provinsi Sumatera Barat sudah di tingkat yang mengkhawatirkan. Kondisi geografis Sumatera Barat yang berhadapan langsung dengan Samudera Hindia membuat sifat tumbukan gelombang di pesisir relatif kuat sehingga abrasi berlangsung dengan cepat. Kerusakan ekosistem mangrove akibat penebangan, alih fungsi lahan, pencemaran muara, dan kerusakan terumbu karang akibat penggunaan bom, potas, dan pemutihan karang, turut mempercepat terjadinya abrasi. Kerusakan pesisir dan pulau-pulau kecil perlu dicegah karena dapat mengurangi keunggulan strategis pertahanan di wilayah terluar, mengganggu efektivitas fungsi infrastruktur sipil dan militer di pesisir, mengganggu stabilitas ekonomi dan mengurangi ruang hidup masyarakat, membahayakan navigasi, dan mengancam keanekaragaman hayati. Tujuan penelitian ini adalah untuk mengetahui sumberdaya dan upaya pemerintah daerah Provinsi Sumatera Barat dalam melindungi pesisir dan pulau-pulau kecil dari abrasi dan dampak perubahan iklim. Penelitian dilaksanakan pada 15-23 September 2019 di Kota Padang dan di Pulau Sipora. Pengumpulan data dilakukan dengan metode observasi, dan wawancara mendalam kepada pejabat instansi pemerintah daerah dan warga di sekitar pesisir. Data dianalisis menggunakan teknik data condensation, data display, dan conclusion drawing. Hasil penelitian menunjukkan instansi-instansi daerah memiliki keunggulan uniknya masing-masing dalam mendukung pencegahan abrasi dan adaptasi perubahan iklim, namun upaya-upaya yang dilaksanakan masih bersifat sporadis, reaktif, tidak terkoordinasi, dan tidak berkelanjutan. Sumber daya bahan baku untuk pencegahan abrasi dan adaptasi perubahan iklim tersedia melimpah di Sumatera Barat, namun sumber daya keorganisasian yang dimiliki instansi daerah relatif terbatas. Kondisi ini membuat abrasi dan dampak perubahan iklim tidak dapat dicegah secara efektif.ABSTRACTWest Sumatera Province has an alarming rate of coastal and small islands destruction caused by abrasion and the effect of climate change. Geographical characteristic of West Sumatera Province which directly face Hindia Ocean quickly have it’s coastal area eroded with abrasion caused by a strong wave. The destruction of mangrove forest and coral reefs further made the abrasion process worse. Coastal and small islands destruction need to be stopped because it could reduce military strategic advantage in national outer areas, reducing the effectiveness of military and civilian infrastructures, destabilizing economy and narrowing the living space of people, endangering the safety of ship navigation, and threatening nature’s biodiversity. The aim of this research is to understand the resources and actions of West Sumatera Province’s local government of how it protect the coastal area and small islands from abrasion and to adapt to the effects of climate change. The research was conducted in September 15 to 23 in 2019 at Padang City and Sipora Island of Kepulauan Mentawai Regency. Data collected by field observation and in-depth interview to officials from local government and the locals. Data analyzed by using data condensation, data display, and conclusion drawing analytical technique. The research shows that each provincional departments under West Sumatera Province local government have it’s own unique approach and technique to prevent abrasion and adapt to the effects of climate change, but the action taken usually implemented sporadically, reactive, uncoordinated, and not sustainable. Natural resources needed to prevent abrasion and to adapt to climate change are abundant, but the Province’s organisational resources is limited, causing the coastal area and small islands innefectively protected

Cascaded microsphere-coupled surface-enhanced Raman spectroscopy (CMS-SERS) for ultrasensitive trace-detection

Surface-enhanced Raman spectroscopy (SERS) has been widely investigated and employed as a powerful optical analytical technique providing fingerprint vibrational information of molecules with high sensitivity and resolution. In addition to metallic nanostructure, dielectric micro-/nano-structures with extraordinary optical manipulation properties have demonstrated capability in enhanced Raman scattering with ultralow energy losses. Here we report a facile cascaded structure composed of a large microsphere (LMS) and a small microsphere array with Ag nanoparticles as a novel hybrid SERS substrate, for the first time. The cascaded microsphere-coupled SERS substrate provides a platform to increase the molecular concentration, boost the intensity of localized excitation light, and direct the far-field emission, for giant Raman enhancement. It demonstrates the maximum enhancement factor of Raman intensity greater than 108 for the limit of detection down to 10−11 M of 4-nitrothiphenol molecules in aqueous solution. The present work inspires a novel strategy to fabricate cascaded dielectric/metallic micro-/nano-structures superior to traditional SERS substrates towards practical applications in cost-effective and ultrahigh-sensitive trace-detection.

New Ways for the Advanced Quality Control of Liquefied Natural Gas

Currently, gas chromatography is the most common analytical technique for natural gas (NG) analysis as it offers very precise results, with very low limits of detection and quantification. However, it has several drawbacks, such as low turnaround times and high cost per analysis, as well as difficulties for on-line implementation. With NG applications rising, mostly thanks to its reduced gaseous emissions in comparison with other fossil fuels, the necessity for more versatile, fast, and economic analytical methods has augmented. This work summarizes the latest advances to determine the composition and physico-chemical properties of regasified liquid natural gas, focusing on infrared spectroscopy-based techniques, as well as on data processing (chemometric techniques), necessary to obtain adequate predictions of NG properties.