The Lymph Node Metastasis Histology in Colorectal Cancer -The Clinical Implication of Tubular-Type Carcinoma in Lymph Nodes -

Cribriform carcinoma in lymph nodes (LNs) is associated with distant metastasis, recurrence, and survival in node-positive colorectal cancer (CRC) patients. However, the clinical significance of lymph node metastasis histology remains to investigate. A total of 318 consecutive CRC patients who underwent a colectomy or anterior resection between January 2011 and June 2016 were enrolled, of whom 119 (37.4 %) had LN metastasis (LNM). Based on the LNM histology, patients with LNM were categorized into four groups: the group with tubular-type in all LNs (tub), with cribriform in at least one LN (cri), with mucinous-type in all LNs (muc), and with poorly differentiated-type carcinoma in at least one LN (por). We investigated the association among these histological types with the survival of these patients. The prognosis was good in order of muc, tub, cri, and por in node-positive CRC patients. Stage II and stage III tub groups did not have significantly different over-all survival times, but not recurrence-free survival times. Multivariate analyses revealed that all tubular-type carcinoma in LNs was independent predictive factor for longer survival times, clinical complete response and possible metastasectomy Diagnosis of lymph node metastatic histology is an important factor for patient stratification in node-positive CRC.

Analysis of the screw press mouthpiece parameters for 3D extrusion of peat pieces of tubular type

The results of theoretical and experimental studies on the creation of a screw press composite mouthpiece screw press for 3D-forming of peat pieces of a tubular type in the field for intensifying the process of field drying of material in a complex mechanized pit are presented. The main purpose of the study was to substantiate the geometric and design parameters of the screw press composite mouthpiece of the spread machine for the production of peat-agglomerated products of the tubular type. The parameters of the mouthpiece are selected based on the geometric characteristics of the peat pieces. An increase in moisture loss during drying of peat-agglomerated products is provided by forming a peat piece in the form of a thick-walled pipe made of a peat raw materials composed of low and high decomposition degrees in a ratio of 1:3. Additive production of polymer-fiber peat composites by extrusion allows to produce products with improved mechanical properties in comparison with non-reinforced raw materials. The vertical arrangement of the peat tubular piece on the drying field allows to increase the loading of the field area by 10 %, increase the convective heat supply to the piece and reduce the contact coefficient of the piece with the field by three times in comparison with the peat spreading of the pieces in the form of a horizontal tape. Based on the analysis of the shape and size of the agglomerated products, the design of a screw press composite mouthpiece consisting of two conditional molding zones of various configurations has been developed. The article presents a parametric analysis of the volumetric productivity of a screw press with a composite mouthpiece of a tubular type, the energy intensity of mechanical processing is determined, the degree of mechanical processing of peat raw materials is estimated with the optimization of the screw parameters for the production of agglomerated products of a tubular type.

Small Heat Source Used for Combustion of Wheat-Straw Pellets

Wheat straw, as a secondary waste agricultural product, presents a potential renewable source of energy. It is necessary to design simple heat sources to achieve better usage. As part of an analysis of heat sources, a tubular type of heat exchanger was reviewed. The design of the exchanger was focused on the smallest possible dimensional requirements, low costs, high reliability and easy maintenance. We chose a tubular type of heat exchanger. In our case, flue gas flows through the tubes, and water flows outside of the tubes. This type of exchanger allows for continuous cleaning, but also simple maintenance, even in case of equipment failure. It is possible to replace individual parts (pipes) of equipment that are exposed to the adverse corrosive effects of biomass flue gases. A mathematical model was composed to compute the construction of a heat source. The model was verified by CFD simulation. The main idea of this design is modularity. The composed model can be used to design a series of similar heat sources with different levels of power, and which, as it is of maximal availability for this type of construction, increase use of waste straw as fuel by small farms.

Geometrical Scaling of Antiresonant Hollow-Core Fibers for Mid-Infrared Beam Delivery

We numerically investigate the effect of scaling two key structural parameters in antiresonant hollow-core fibers—dielectric wall thickness of the cladding elements and core size—in view of low-loss mid-infrared beam delivery. We demonstrate that there exists an additional resonance-like loss peak in the long-wavelength limit of the first transmission band in antiresonant hollow-core fibers. We also find that the confinement loss in tubular-type hollow-core fibers depends strongly on the core size, where the degree of the dependence varies with the cladding tube size. The loss scales with the core diameter to the power of approximately −5.4 for commonly used tubular-type hollow-core fiber designs.

Computational Classification of Tubular Algebras

The effective method (based on Theorem 5.3) of classifying tubular algebras by the Cartan matrices of tilting sheaves over weighted projective lines with all indecomposable direct summands in some finite “fundamental domain” , by the reduction to the two elementary problems of discrete mathematics having algorithmic solutions is presented in details (see Problem A and B). The software package CART_TUB being an implementation of this method yields the precise classification of all up to isomorphism tubular algebras of a fixed tubular type p, by creating the complete lists of their Cartan matrices, and furnish their tilting realizations. In particular, the number of isomorphism classes of tubular algebras of the type p is determined (Theorem 2.3).

Comprehensive transcriptomic analysis provides new insights into the mechanism of ray floret morphogenesis in chrysanthemum

Background The ray floret shapes referred to as petal types on the chrysanthemum (Chrysanthemum × morifolium Ramat.) capitulum is extremely abundant, which is one of the most important ornamental traits of chrysanthemum. However, the regulatory mechanisms of different ray floret shapes are still unknown. C. vestitum is a major origin species of cultivated chrysanthemum and has flat, spoon, and tubular type of ray florets which are the three basic petal types of chrysanthemum. Therefore, it is an ideal model material for studying ray floret morphogenesis in chrysanthemum. Here, using morphological, gene expression and transcriptomic analyses of different ray floret types of C. vestitum, we explored the developmental processes and underlying regulatory networks of ray florets. Results The formation of the flat type was due to stagnation of its dorsal petal primordium, while the petal primordium of the tubular type had an intact ring shape. Morphological differences between the two ray floret types occurred during the initial stage with vigorous cell division. Analysis of genes related to flower development showed that CYCLOIDEA genes, including CYC2b, CYC2d, CYC2e, and CYC2f, were differentially expressed in different ray floret types, while the transcriptional levels of others, such as MADS-box genes, were not significantly different. Hormone-related genes, including SMALL AUXIN UPREGULATED RNA (SAUR), GRETCHEN HAGEN3 (GH3), GIBBERELLIN 2-BETA-DIOXYGENASE 1 (GA2OX1) and APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF), were identified from 1532 differentially expressed genes (DEGs) in pairwise comparisons among the flat, spoon, and tubular types, with significantly higher expression in the tubular type than that in the flat type and potential involvement in the morphogenesis of different ray floret types. Conclusions Our findings, together with the gene interactional relationships reported for Arabidopsis thaliana, suggest that hormone-related genes are highly expressed in the tubular type, promoting petal cell division and leading to the formation of a complete ring of the petal primordium. These results provide novel insights into the morphological variation of ray floret of chrysanthemum.