Insulin and IGF-1 receptors mutations can lead to targets for gene therapy in diabetes, obesity, and metabolic syndrome

Insulin and IGF-1 signaling are found in nearly every cell in the body and are important for metabolism, development, and differentiation. Despite considerable progress, understanding the basic reason for abnormal insulin receptor signaling in type 2 diabetes, obesity, and metabolic syndrome remains a challenge. In the future decade, integrating several omics layers into a unique disease profile and translating these insights into novel and personalised therapies will be a big challenge.

Pierce Similarity Algorithm In Detection Of Jar Letter In Al-Quran As Basic Media For Learning Arabic Language Structure

Al-Quran is the basic reason someone should understand the rules of Arabic. One of the basic rules is knowing the jar type which we generally often encounter in Arabic, but we do not understand that this letter has its own duties and functions. In this study, samples of Jar letters were used as many as 7 jar letter patterns which are generally often encountered in the Al-Quran. The purpose of this research is to build a system that can recognize Jar letters using the Pierce Similarity method and performs the performance on the algorithm. The research method used is the theory of pattern recognition in image processing with 2 processes, namely the Training Process and the Testing Process. The value of each letter pattern obtained in the Training Process will be the weight benchmark for the Testing Process, so that we can measure the performance level of Algortima Pierce Similarity in detecting the Jar letter pattern. The results can vary for each letter pattern ranging from 60% to 80%.

Cultural Transfer and Dialogue of Cultures in the Russian and Latin American Civilizational Borderlands

The article compares “cultural transfer” and “dialogue of cultures” as socio-cultural realities in two "border" civilizations of planetary scale – Latin America and Russia. The author develops and illustrates the thesis that identity of subjects of intercultural interaction is a necessary precondition and the key to cultural transfer. The focus is on the problematics of the dialogue of cultures. According to the author, the basic reason for all difficulties to put into practice the ideal of dialogue consists in what W. O. Quine described as the problem of "radical translation", that is, of understanding texts created within another culture based on essentially different views about the universe and life.

Merayakan Persahabatan Yang Memerdekakan Refleksi Atas Pandangan Odo Casel Tentang Misteri Kehadiran Karya Keselamatan Dalam Liturgi

Scripture shows that liturgy is the basic reason why GOD saved his people so that God’s chosen people might freely worship God (Ex 4:23) in spirit and truth’ (Jn 4:24). Liturgy becomes a mediator and a moment for the real presence of God’s saving deed. The relationship between God and His/Her people is drawn into a reality in our liturgy. Odo Casel reflects on our relationship with God is not a mere speculative idea but it is an objective reality that happens in our daily life. The Encyclic Mediator Dei emphasizes the Divine aspect of God’s grace in the history of salvation that restored our relationship with God.

Religious Trust, Anti-Trust, and Reasons for Religious Belief

This chapter begins by distinguishing two kinds of epistemic reasons, one irreducibly first personal, and the other third personal. Here the kinds of reasons that are irreducibly first personal are called “deliberative reasons,” and the kinds of reasons that are third personal are called “theoretical reasons.” The use of the terms “deliberative” and “theoretical” is not essential to the distinction being made, but these terms draw attention to the different functions of the two kinds of reasons in psychology. Epistemic self-trust is an irreducibly first personal epistemic reason, and it is the most basic reason of either kind. Attacks on religious belief are sometimes third personal, but sometimes they are first personal attacks on self-trust or trust in religious communities. Attacks on self-trust require a different kind of response than attacks on third person reasons.

Jews Claim on Masjid Aqsa; Historical and Sharῑ’ah Perspective

Palestine’s issue has been one of the most vibrant issues of the Muslim Ummah thou out the Islamic history. It has contracted more attraction and reflection in contemporary era due to its sensitivity and global politics. Masjid Aqsa is considered as a scared and blessed place for Muslims due to prophets’ birth and death places, and also station of Isrā and M’erāj (A sacred journey of the Holy Prophet ﷺ) from Makah to Aqsa and Aqsa to heaven with Allah’s meeting of the last Prophet (ﷺ). Moreover, this place is equally significant for Muslims and Jews communities both for their religious claims and commitments. Jews made claim on Masjid Aqsa due to its historical and religious importance. Most interesting thing is that, where Masjid Aqsa is a blessed and sacred place as well as, it is a basic reason of conflict and dispute between Muslims and Jews since establishment of the State of Israel. Jews claim, here was temple of Suleiman (A.S) under the foundations of Masjid Aqsa and Muslims claim, it is blessed and sacred masjid which was first Qiblah of Muslims and Haram also. Historically and religiously it is right of Muslims and Jews are hurting the religious sentiments of the Muslim which is wrong and violations of the Muslims religious and human rights. This study is an effort to analyze the historical and religious arguments of Muslims and Jews about ownership of the Masjid Aqsa and presents a solution regarding Palestine issue in contemporary era. The analytical, historical and comparative approaches have been adopted in this research with qualitative approach.

Integral models of local Shimura varieties

This chapter explains an application of the theory developed in these lectures towards the problem of understanding integral models of local Shimura varieties. As a specific example, it resolves conjectures of Kudla-Rapoport-Zink and Rapoport-Zink, that two Rapoport-Zink spaces associated with very different PEL data are isomorphic. The basic reason is that the corresponding group-theoretic data are related by an exceptional isomorphism of groups, so such results follow once one has a group-theoretic characterization of Rapoport-Zink spaces. The interest in these conjectures comes from the observation of Kudla-Rapoport-Zink that one can obtain a moduli-theoretic proof of Čerednik's p-adic uniformization for Shimura curves using these exceptional isomorphisms. The chapter defines integral models of local Shimura varieties as v-sheaves.

Economic and Social Rights Lost in Transition

All European constitutions after World War II expressed their commitment to economic and social rights. Those countries that began building socialist social order after the war specially emphasized those rights. After the break-up of the “socialist paradigm” and the establishment of “new democracies”, constitutional leaders have taken a new stance towards the socio-economic group. This is the process that did not bypassed countries formed by dissolution of Yugoslavia. We will analyse specially what is left of the constitutional experiment of self-management. Nowadays, there is no workers’ participation in place in any of the countries that emerged after the breakup of the former Yugoslavia, neither as a system nor as a practice of having consultations within companies with the aim to address specific technological, organisational and social problems. There are several reasons for this, but the basic reason is that politicians still believe that workers’ participation was created as part of the ideological apparatus of the former socialist system. By way of property rights and small shareholding, the laws opened the way to participation, and the legal framework could continue to develop.

The Eminence of Incubation in Creative Procces As The Basic Reason of Recreation Space Development at Work

Creative People are known to be different in their perceptions and interpretations of their work problems, depending on the characteristics of the current situation occur (Dorst & Cross, 2001). The creative process that people usually see cannot be seized by any methodology, but the creative people actually implement different types of methods. Methods have flexibility in processes, actions, and appreciations (Roozenburg & Dorst, 1998; Stempfle & Badke-Schaub, 2002). Creative people usually have unique characteristics while doing their job. They need some supportive situations or environments to embrace the imagination as they create an idea of the creative process. Sometimes, the ideas come out in unexpected situations, either in a relaxed situation or under pressure situations. The second stage of creative thinking from the four stages presented by Graham Wallas (1926) is the Incubation Stage which becomes the focus of this research. The need for the incubation stage will be used as one of the variables of the user aspect approach for leisure facility design which is the output expectation from this research for the recommendation of designing the facility in a Co-Working Space.

From Frustrated Desire to Posthumous Harm

This chapter provides an extensive defense of the third premise of the book’s central argument: the claim that if frustrating a person’s desires is one way to harm a person then it is possible for an act to wrongfully harm a person even if the act takes place after the person is dead. After an overview, the chapter begins by presenting the basic reason for thinking that if the Desire Satisfaction Principle is true, then the Posthumous Harm Thesis is true. It then considers a series of objections that can be raised against the claim and responds to each of them.