A Controlled Study of the EEG in Anorexia Nervosa

The nutritional disturbance in anorexia nervosa almost invariably leads to striking physiological changes, which include amenorrhoea, bradycardia, hypotension and relative hypothermia with reversal of the usual diurnal temperature rhythm (Bliss and Branch, 1960; Mayer-Grosset al., 1960; Crisp and Roberts, 1962; Crisp, 1967a). Crisp (1965a, 1967a) has commented on the characteristic and excessive alertness, restlessness and insomnia displayed by anorexia nervosa patients, whom he regards as showing a specific type of malnutrition associated with carbohydrate starvation. Russell (1967) has also recently demonstrated that patients with this illness restrict especially their carbohydrate intake.

CEROID STORAGE DISEASE IN CHILDHOOD

Two cases of ceroid storage in childhood are reported. In both cases there was a long history of nutritional disturbance and cirrhosis of the liver was found at necropsy. In one case the storage of ceroid followed the pattern of so-called "lipidoses," with massive numbers of ceroid-filled cells in the spleen, liver and intestinal mucosa. In the other case the deposition of ceroid occurred mostly in macrophages in the liver. No ceroid was found in smooth muscle or other parenchymal cells as in vitamin E deficiency.