The extraordinary paleontological record from Big Bend National Park (BIBE), Texas chronicles nearly 120 million years of largely uninterrupted deposition through Late Cretaceous, Paleogene and Neogene time. Therefore, the park records one of the most complete and continuous fossil records of its kind in North America, if not the world. Paleontologists have collected and studied fossils from BIBE for over a century and nearly 1400 fossil species have been reported thus far. The BIBE paleontological record includes type specimens representing 44 scientifically valid species (five plants, nine invertebrates, and 30 vertebrates). Numerous other reported specimens are very likely new to science but have yet to be formally named. The present catalog presents the currently known assemblage of fossil plant, invertebrate, and vertebrate species from BIBE within a single, comprehensive record with significant references for each. This work is designed and written to be a research and resource management tool for scientists and non-scientists alike.