Chiroptical Properties and Conformation of Four Lasiocepsin-Related Antimicrobial Peptides: Structural Role of Disulfide Bridges

We report an investigation of the role of disulfide bridges in the 27-residue antimicrobial peptide lasiocepsin (I) containing two disulfide groups (Cys8–Cys25, Cys17–Cys27) and three its analogs lacking one (II, III) or both (IV) native disulfides. Selective alternate incorporation of one or both disulfide bridges influences symmetry, conformation and biological properties of these peptides as demonstrated in their chiroptical (particularly Raman) properties. The effect of modifying the disulfide bridge pattern on the peptide secondary structure is investigated in water and in the presence of 2,2,2-trifluoroethanol and sodium dodecyl sulphate. A combination of experimental electronic and vibrational chiroptical data shows that both disulfide groups are necessary for stabilizing lasiocepsin secondary structure. While the Cys8–Cys25 disulfide group is important for sustaining lasiocepsin tertiary structure and maintaining its biological activity, the Cys17–Cys27 disulfide bridge has a supporting function consisting in reducing peptide flexibility.

Study on the Transparent Electronic Isolation Layer Material - A Photoresist Composition which is Stable at High Temperature and Humidity

A negative resist composition composed of an acrylic-copolymer-binder resin, a crosslinker, photoinitiators, some agents and solvents has been UV-cured and developed for OverCoat (OC)-Bridge of One Glass Solution (OGS) touch panel (TP) sensor, wherein acrylic-copolymer-binder resin as a key element consisting of N-Phenylmaleimide (N-Pm), Methacrylic acid (MA), Styrene (St) and Isobornyl methacrylate (iBMA) monomers, being designed and synthesized to control the acid value (90-110mgKOH/g), molecular weight (Mw:10,000-20,000) and approximate solubility parameter [10.67-11.05(cal/cm3)1/2]. Here,we demonstrate a OC photoresist applies between two ITO line-films by UV-curing process technology deveoled for OC-Bridge pattern with a kind of acrylic-copolymer-binder resin by ours. Acting as TP sensor, the OC patterns have adequate resistance to solvents, acids and alkalis, good thermal and humid stability, and with excellent transparency and insulation. This OC photoresist, coupled with the acrylic-copolymer-binder resins, provides an unprecedented approach to realize supporting high temperature and humidity OC-Bridge.

A Study on Model Transformation Mechanism Using Graph Comparison Algorithm, Abstract Factory Pattern and Bridge Pattern

In order to easily port mobile applications suitable for each platform, that have been developed under diverse development environment for individual wireless communication service providers, or redevelop them on a specific platform, it is required to reuse them at software model level that is a software development paradigm for MDA (Model Driven Architecture). Verification of existing design models and test models for the study, mainly checking (Model Checking) with a code-based software designed to define in the abstract syntax tree or on the models generated using refactoring on design models for refinery operations and define how to perform. The problem with these traditional research methods, but the first model, design model for checking the information with the model by defining a formal representation in the form of an abstract syntax tree, as you've shown how to perform verification of the model to perform refactoring. Additional steps need to define more complex due to a software problem that is not the way to the model suitable for optimization refactoring. In this paper, as defined in the MDA-based model transformation studies of a reusable model transformation patterns, abstract factory pattern and the bridge pattern given the pattern information automatically through the software model offers a way to perform refactoring..