Clinical Pharmacology of Fentanyl in Infants and Children

Fentanyl is a systemic opioid related to the phenylpiperidines, it is used in anaesthetic practice and in analgesia and the analgesic effect is about 100 times higher than that of morphine. Fentanyl is highly lipid soluble, rapidly crosses the blood-brain-barrier, and fentanyl concentrations rapidly decline in plasma and cerebrospinal fluid. Fentanyl causes respiratory depression and decreases the heart rate through vagal activation. Fentanyl may be administered intravenously, orally, by transdermal, intranasal or by buccal application and the oral bioavailability is poor. In infants, fentanyl is given for short term use, sustained use, and during therapeutic hypothermia. In children, fentanyl is given intravenously, by transdermal application, or by buccal administration and the fentanyl dose varies with the child age and body-weight. Fentanyl has been found efficacy and safe in infants and children but it may induce adverse-effects and fentanyl causes different effects in infants and children. Following intravenous administration of fentanyl to infants and children, the fentanyl elimination half-life ranges from 208 to 1,266 min and the distribution volume ranges from 1.92 to 15.2 L/kg. Such variability is due to the wide variation of subject’s demographic characteristics. Fentanyl interacts with drugs, the treatment and trials with fentanyl have been studied in infants and children. Fentanyl freely crosses the human placenta and poorly migrates into the breast-milk. The aim of this study is to review fentanyl dosing, efficacy, safety, effects, adverse-effects, metabolism, pharmacokinetics, drug interaction, treatment, and trials in infants and children, and fentanyl placental transfer and migration into the breast-milk.

Effect of Foliar Application of Glutamic Acid and Nano Zinc Oxide on The Active Compounds and Phenols of Goldenrods (Solidag SP)

The experiment was conducted in the Department of Horticulture, College of Agriculture, Tikrit University for the agricultural season 2020. Two factors were studied: first; foliar application of glutamic acid at three levels (0.100,200) mg.L-1 and the second; nano zinc oxide at four levels (0,0,50,1,1050) mg.L-1 in Randomized Complete Block Design ( RCDB) with three replication. The interaction A2Z3 treatment (glutamic acid 200 mg. L-1 + nano zinc oxide 1.50 g.L-1) was achieved the highest values of a-Pinene, limonene, Linalool and Myrcene Terpinen which reached (31.4, 20.3, 22.4, 27.4 and 28.2 mg.L-1) respectively, compared to the control treatment. Whereas the interaction treatment A2Z2 (glutamic acid 200 mg.L-1 + nano zinc oxide 1 g.L-1) achieved the highest values of Camphene (35.6 mg. L-1). While the interaction of A2Z3 (glutamic acid 200 mg.L-1 + nano-zinc oxide 1.50 g.L-1) was recorded the highest concentration of Rutin and Caryophyllene, which reached (40.1 - 253.8 μg.ml-1 ) respectively, While the interaction treatment A1Z3 (glutamic acid 100 mg.L-1 + nano zinc oxide 1.50 g.L-1) was achieved the highest value of Qurcetine (192.9 μg.ml-1).

Effect of Foliar Application of Bimin221 and Seaweed Extract on Lime Seedling Growth

This study was conducted in a certified citrus production nursery in Karbala province, Al-Hindiya district for the season 2020, on lime seedlings (Citrus aurantifolia) rootstock at the age of 6 months, It was sprayed with the nutrient solution Biumin 221 at concentrations (0, 1.5, 2, 2.5 m.L-1) and Basfoliar Kelp seaweed extracts at concentrations (0, 1.5, 3, 4.5) ml L-. The results showed that spraying the seedlings with single and combined study treatments led to a significant increase in all the vegetative and nutrition traits of lime seedlings. The treatment (2.5 g.L-1 nutrient solution + 4.5 ml.L-1 seaweed extract) achieved the highest averages in most of the traits. While the interaction treatment between the concentration (2.5 g.L-1 of the nutrient solution and concentration of 3 ml.L-1 of seaweed extract was excelled in the traits of leaf content of total carbohydrates, the percentage of nitrogen, iron, and zinc.

Effect of Cysteine in Stimulating Some Active Compounds in Garlic Callus Under Different Light Spectra in Vitro

This study was conducted in tissue culture laboratories, Faculty of agriculture, University of Kufa in 2020. The experiment included studying the effect of two factors: type of light: (mixture spectra of red and blue LED R16 : B2), (Fluorescent : normal white light) in interaction with different concentrations of cysteine( 0, 50, and 100 mg.L-1). A completely randomized design (C.R.D) were used with two factor and three replicates. The combined spectra (LED R16:B2) increased the active compounds Di-allyldisulfide and Vinyldithiin (131.33,121.41μg.g-1 F.W. ) respectively. Cysteine (100 mg.L-1) was significantly superior compare to other treatments in producing Di-allyldisulfide and Vinyldithiin content (158.87, 144.35 μg.g-1 F.W) respectively. Results also indicated that the interaction treatment between (LED R16:B2) and (Cysteine 100 mg.L-1) gave significant increase in Di-allyldisulfide and Vinyldithiin content (184.28, 146.07μg.g-1 F.W) respectively. While the tretment (Fluorescent W) and (Cysteine 50 mg.L-1) gave significant increase in Allicin content (195.38 μg.g-1 F.W).

Effect of Magnetization of Nano Fertilization on The Growth and Yield of Wheat Triticum Aestivum L

A field experiment was conducted in Al-Fadhiliya city, Dhi Qar province during the winter agricultural season 2019 - 2020 for the purpose of studying the effect of magnetization of nano Fertilization on the growth and yield of wheat. The experiment was carried out according to Split Plot Design and using the RCBD Design with three replications. The first factor included Magnetization levels of the Nano Fertilization (Gs) (0 Gs (Gs1),750 Gs (Gs2),1500 Gs (Gs3) for 15 minute (in main plot) while the second factor included the Nano Fertilization levels for (N, P) (F) 1 Kg.ha−1(F1), 1.5 Kg.ha−1(F2), 2 Kg.ha−1(F3)(according to the recommendation of the manufacturer (1 - 2 Kg.ha−1))(in sub plot). Mineral fertilizer add for (N, P) by 120 Kg N.ha−1, 100 Kg P ha−1. Mineral and nano fertilizer section for three growth stages (ZGs21, ZGs32, ZGs49). The results showed a positive response to the studied traits of variety Bohouth 22 (Plant height, number of tillers, number of grains and total grain yield) given the highest averages at the level of magnetism (Gs3) and fertilization level (F3)(109.33 cm, 426.2 tiller.m−2, 73.22 grain. spike−1, 1.859 t.d−1),(108.44 cm, 471.4 tiller.m−2, 77.78 grain. spike−1, 1.915 t.d-1) respectively, while the level of magnetism (Gs1) and fertilization level (F1) giving the lowest averages (95.11 cm, 341.3 tiller.m−2, 60.11 grain. spike−1, 1.437 t.d−1), (96.22 cm, 312.1 tiller.m−2, 54.00 grain. spike−1, 1.412 t.d−1) respectively. The level of magnetism (Gs1) and fertilization level (F1) gave the highest average in weight 1000 grain (43.188, 44.266)g respectively, while the magnetization level (Gs3) and fertilization level (F3) giving the lowest average (42.092,41.182)g respectively. Interaction treatment (Gs3F3) gave the highest average grain yield 2.1773 t.d−1 while the interaction treatment (Gs1F1) gave the lowest average attained 1.218 t.d−1.

Effect of Seed Stimulation With Gibberellin and Use of Mineral and Nano Fertilization on Growth and Yield of Wheat Triticum aestivum L.

A field experiment was carried out in Al-Fadhiliya city, Dhi Qar province during the winter agricultural season 2019-2020 to find out the effect of stimulation (soaking) wheat seeds with gibberellin and use of mineral and nano fertilization on some growth and yield characteristics of the Ibaa variety 99. Using RCBD Design with split plot arrangement with three replications. The first factor (main plot) included fertilization levels (F) mineral fertilizer recommendation for N, P ( F1 ), Nano fertilizer recommendation for N, P ( F2 ) and 0.5 mineral fertilizer recommendation + 0.5 Nano fertilizer recommendation ( F3 ).The second factor (sub plot) included the seed stimulation levels (drenching) with gibberellin (G) for 12 hour: 0.0 mg.G.L-1 (water only) ( G1 ), 50 mg G.L-1 (G2), 100 mg G.L-1(G3). The results showed superior the level of fertilization (F3) in traits (plant height 110.33 cm, flag leaf area 54.45 cm 2, number of tillers 389.00 tiller.m-2, number of grains per spike 67.11 grain.spike-1, grain yield 7.589 t.ha-1). While, the level of fertilization (F2) exceeding in adjective (weight 1000 grain 49.18 g). However, the level of stimulation (G2) superior in traits (plant height 106.00 cm, flag leaf area 54.267 cm - 2, number of tillers 381.44 tillers.m-2 and the total grain yield 7.344 t.ha-1). Whereas, the level of stimulation (G3) exceeding in adjectives( number of grain per spike 71.22 grain.spike-1 and weight 1000 grain g). Interaction treatment (F3G2) gave the highest average of total grain yield by 8.133 t.ha-1.

Interaction with patients of color or ethnic minority (PCEM): Oncologist perceptions of racial anxiety and/or implicit bias (RA/IB).

141 Background: Oncologists interacting with PCEM may be unaware of RA/IB, yet data show lower-quality care. Helping oncologists recognize this may improve quality of patient-provider interaction, care, and outcomes. We conducted a descriptive study of medical/hematologic oncologists to assess perceptions of RA/IB impact on PCEM interaction. Methods: From February to April 2021, U.S.-based medical/hematologic oncologists participated in an online survey of perceptions on cancer care and outcomes in PCEM (part of broader survey of various clinical and practice-related concerns). Questions used a modified 5-point Likert scale with an option of declining to answer, and respondents were aware data would be anonymized and aggregated. Results: Among 369 physicians surveyed, median years in practice were 17 (range 2-49). Most (72.4%) were in community settings; 64.0% were age 40 to 59 years; 20.6% identified as female, 70.5% male, and 8.7% declined to disclose. Racial distribution was 32.0% White, 33.1% Asian, 7.0% Black, 4.1% Hispanic/Latinx, and 18.7% declined to disclose. When asked the degree of RA/IB White providers had toward PCEM, 39.6% chose low/none, 33.3% moderate, 14.9% high/very high, and 12.2% declined. When asked whether RA/IB among White providers adversely affects PCEM, 37.1% somewhat/strongly agreed, 29.3% somewhat/strongly disagreed, 23.6% neither agreed nor disagreed, and 10.0% declined. Also, 7.9% declined to estimate percent of non-White patients managed. Perceived frequency of scenarios involving RA/IB impacting PCEM interaction at their practices was also assessed (Table). Notably, 12.0% to 14.0% declined to answer regarding their own practices. Although most oncologists (76.4%) perceived RA/IB among White providers toward PCEM, only 37.1% agreed it had adverse effects. Conclusions: Discrepancy in perception of RA/IB among White providers and its effect on PCEM suggests a need to show causality, and declining to respond suggests mistrust/apprehension in expressing true views. Findings suggest oncologists may benefit from improved education and awareness regarding RA/IB in PCEM interaction, treatment, and outcomes. Provider responses (N=369).[Table: see text]

Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling

Neural precursors (NPs) present in the hippocampus can be modulated by several neurogenic stimuli, including environmental enrichment (EE) acting through BDNF-TrkB signaling. We have recently identified NPs in meninges; however, the meningeal niche response to pro-neurogenic stimuli has never been investigated. To this aim, we analyzed the effects of EE exposure on NP distribution in mouse brain meninges. Following neurogenic stimuli, although we did not detect modification of the meningeal cell number and proliferation, we observed an increased number of neural precursors in the meninges. A lineage tracing experiment suggested that EE-induced β3-Tubulin+ immature neuronal cells present in the meninges originated, at least in part, from GLAST+ radial glia cells. To investigate the molecular mechanism responsible for meningeal reaction to EE exposure, we studied the BDNF-TrkB interaction. Treatment with ANA-12, a TrkB non-competitive inhibitor, abolished the EE-induced meningeal niche changes. Overall, these data showed, for the first time, that EE exposure induced meningeal niche remodeling through TrkB-mediated signaling. Fluoxetine treatment further confirmed the meningeal niche response, suggesting it may also respond to other pharmacological neurogenic stimuli. A better understanding of the neurogenic stimuli modulation for meninges may be useful to improve the effectiveness of neurodegenerative and neuropsychiatric treatments.

Effect of suckling and weaning systems on age, weight at puberty, and some reproductive traits in Awassi sheep: تأثير نظم الرضاعة والفطام في العمر والوزن عند البلوغ الجنسي وبعض الصفات التناسلية في الأغنام العواسية

A flock of seventy-two Awassi ewes aged five years were used in this study to evaluate the effects of three suckling system (24, 15, 9) hours and two weaning system at the weight of (15 and 20) Kg on age, weight at puberty, scrotum circumference and size and some characteristics of semen of Awassi lambs. Suckling and weaning systems had a significant effect (p≤0.05) on age and weight at puberty for males and the benefit of the suckling group for 24 hours and the weaning system of 20 kg. At 5 and 6 months of age, the suckling system had a significant effect (p≤0.05) on the circumference and size of the scrotum. At 6,7 and 8 months, the influence of the weaning system on the circumference and size of the scrotum, with the superiority of the suckling group 24 hours and the weaning system of 20 kg, a gradual and significant increase (p≤0.05) in the circumference and size of the scrotum was observed with age, and a significant improvement (p≤0.05) was observed in the characteristics of semen as the measurement period progresses. The lambs in the 24-hour suckling group gave the best semen consistency at puberty and after 4 weeks of puberty, and the 24-hour suckling group was superior than suckling group 9 hours in individual motility of sperm at puberty, and the interaction coefficients had a significant effect on age, weight at puberty, circumference and size of the scrotum at 5,6-and 7- months of age. The interaction between treatment effect on the size of semen in the second collection after puberty and its consistency at puberty also at the second collection the interaction had a significant effect (p≤0.05) on the individual and mass motility of the sperms at puberty and in the mass motility on the second collection of semen. Suckling and weaning systems had no significant effect on age and weight at puberty for female except for the superiority of the second interaction treatment on the third in weight at puberty which reached 37.88 and 27.80 kg respectively. The aim of this study was to find out the effect of suckling and weaning system for reaching sexual puberty and determining the age and weight at puberty in male and female Awassi sheep in addition to their effect on the circumference and size of the testicle and some of the semen characteristics of lambs, which are important characteristics for raising reproductive efficiency of the flock. The study recommends following the 24-hour suckling system and 20 kg weaning system, which leads to approach male lambs at a lower age and higher weight at sexual puberty.

PENGARUH KONSENTRASI DAUN BELIMBING WULUH (Averhoa bilimbi L.) DAN LAMA PENYIMPANAN TERHADAP KUALITAS FISIK TELUR PUYUH

The purpose of this research was to analize physical quality of quail eggs which has soaked with wuluh star fruit leaves extract and has storaged for some weeks. This research used 108 quail eggs, 0 day old. This research used a Completely Randomized Design with 6 leaves extract concentrastion treatments (0%, 10%, 15%, 20%, 25%, and 30%) and 6 durations of storage treatments (0, 1, 2, 3, 4, and 5 weeks) with three replication. The data were analyzed by ANOVA 5% and continued with Duncan test. The result showed that leaves extract concentrastion treatments gave significant effect to egg weight, eggshell weight, egg white weight, yolk score, albumin pH, Haugh Unit (HU), and the shell thick of quail eggs. The interaction treatment gave significant effect to eggshell wheight, albumin pH, and the shell thick of quail eggs.