Carbene-Enabled Ether Activation Through the Formation of Oxonium: A Theoretical View

Here, we report a theoretical investigation of the reactivity and chemoselectivity of carbene-enabled ether activation. The mechanism obtained from DFT calculations revealed that the final products were dependent on the...

Apical Amplification – A Cellular Mechanism of Conscious Perception?

We present a theoretical view of the cellular foundations fornetwork-level processes involved in producing our conscious experience.Inputs to apical synapses in layer 1 of a large subset of neocortical cellsare summed at an integration zone near the top of their apical trunk. Theseinputs come from diverse sources, and provide a context within which thetransmission of information abstracted from sensory input to their basal andperisomatic synapses can be amplified when relevant. We argue that apicalamplification (AA) enables conscious perceptual experience and makes it moreflexible, and thus more adaptive, by being sensitive to context. AA providesa possible mechanism for recurrent processing theory that avoids strongloops. It makes the broadcasting hypothesized by global neuronal workspacetheories feasible while preserving the distinct contributions of theindividual cells receiving the broadcast. It also provides mechanisms thatcontribute to the holistic aspects of integrated information theory. As AAis highly dependent on cholinergic, aminergic, and other neuromodulators, itrelates the specific contents of conscious experience to global mental statesand to fluctuations in arousal when awake. We conclude that apical dendritesprovide a cellular mechanism for the context-sensitive selectiveamplification that is a cardinal prerequisite of conscious perception.

The Anxiety Caused by Secondary Schools for Autistic Adolescents: In Their Own Words

Secondary schools are increasingly becoming inclusive of all students whatever their individual needs, but we question whether teachers understand enough about specific needs in order to effectively support all their students. Research indicates that autistic students often struggle with aspects of school (conformity; social communication; sensory challenges; bullying) but very few studies ask autistic adolescents about their experiences. One of the key elements of the school experience for autistic adolescents is the levels of anxiety experienced by many students on a daily basis. This research set out to explore the extent to which autistic students in secondary schools in the UK were able to recognise and reflect on their own anxiety. The eighteen participants in this co-produced qualitative study took part in semi-structured interviews planned by a team of autistic and non-autistic researchers. The themes that emerged from this study, in terms of triggers for anxiety, included other people’s behaviour, fear of the unknown, and sensory sensitivities. A theoretical view of their difficulties concurs with the concept of intolerance of uncertainty. Our data suggest that autistic students continue to experience high levels of anxiety throughout their secondary education, despite supports put in place by some schools. Strategies are highlighted that could be implemented by all schools to promote truly inclusive settings.

A Review of the Impact of Reforms on Financial Viability and Sustainability of Tanzania’s Power Sector

In Tanzania, reforms were mooted in the 1990s to solve two intertwined problems; the financing of investment and reducing the fiscal drain on the government to the sector. This study deploys the ARDL Model and paired-sample t-statistic tests, with profitability and liquidity data from 1989 to 2020 to examine the impact of the reforms on sectoral financial condition in Tanzania. The results suggest that both profitability and liquidity did not significantly improve after reforms. Apart from commercialization policy, other variables were not statistically significant with privatization and liberalization law exerting a negative pressure on liquidity. The findings, therefore, appear to contradict the theoretical view that the reforms improve the financial condition of both the sector and the governments. The outcome can be explained by unfinished reforms manifested by continued politicization of the sector hence underpricing and underinvestment. To ensure sectoral financial viability and sustainability we recommend that the reform policies such as commercialization, corporatization, and independent regulation should be prioritized. These findings will add value to policymakers in Tanzania and beyond which are reforming their power sectors by recognizing that efficient pricing and investment are key for a viable and sustainable financial condition of the sector.

The courage to teach with compassion: Enriching classroom designs and practices to foster responsiveness to suffering

Recognizing the prevalence of suffering among management teachers and students, we raise the importance of compassion as central to the practice of management teaching. To aid in understanding how suffering and compassion arise in management teaching, we call upon a theoretical view of their rhizomatic structure, which conveys the widespread, complex, and largely unspoken spreading of suffering and corresponding need for compassion in the work of management teaching. To meet this suffering with compassion, we propose two clusters of practices central to teaching that lend themselves to helping management teachers see possibilities for more skillfully intertwining suffering and compassion. The first focuses on how management teachers can design the context for teaching in ways that make compassion more likely, focusing specifically on roles and networks. The second draws upon Honneth’s recognitional infrastructure to focus on how teachers can approach the relational practice of teaching with emphasis on enriching human recognition of suffering. We conclude with a caution about overly simplistic approaches and overly individualized views of compassion in the work of management teaching. We call for systemic approaches to action that will enrich our imaginations as we approach management teaching and its role in our collective responsiveness to suffering.

Two classes of functional connectivity in dynamical processes in networks

The relationship between network structure and dynamics is one of the most extensively investigated problems in the theory of complex systems of recent years. Understanding this relationship is of relevance to a range of disciplines—from neuroscience to geomorphology. A major strategy of investigating this relationship is the quantitative comparison of a representation of network architecture (structural connectivity, SC) with a (network) representation of the dynamics (functional connectivity, FC). Here, we show that one can distinguish two classes of functional connectivity—one based on simultaneous activity (co-activity) of nodes, the other based on sequential activity of nodes. We delineate these two classes in different categories of dynamical processes—excitations, regular and chaotic oscillators—and provide examples for SC/FC correlations of both classes in each of these models. We expand the theoretical view of the SC/FC relationships, with conceptual instances of the SC and the two classes of FC for various application scenarios in geomorphology, ecology, systems biology, neuroscience and socio-ecological systems. Seeing the organisation of dynamical processes in a network either as governed by co-activity or by sequential activity allows us to bring some order in the myriad of observations relating structure and function of complex networks.

Beyond the platform: Music streaming as a site of logistical and symbolic struggle

Research on music streaming has so far tended to normalize a view of streaming as an individual activity solely oriented towards the platform. However, as streaming media have become integral to everyday life and a key metaphor for digital society, we should pay attention to how streaming activities are embedded into social power relations. Furthermore, due to the complexity of streaming infrastructures, we should consider the social implications of ordinary expertise pertaining to the handling of digital streams. To this end, this article advances a theoretical view of music streaming as a form of logistical labour and a part of dwelling. Based on a focus-group study on music streaming, the analysis moves beyond the platform to explore social dominance in a cultural landscape where logistical expertise is increasingly important. The analysis shows how the handling of everyday infrastructures underpins complicit forms of logistical dominance and translates into symbolic violence.

Linking Homeostatically Protected Mood, Mindfulness, and Depression: A Conceptual Synthesis and Model of Moodfulness

Mindfulness is an ancient practice, derived from Buddhism and recently adapted for the treatment of depression and other psychological conditions. The mechanism of action is thought to involve the extinction of habitual or conditioned responses to internal cognitive and emotional content. In turn, this relies on mechanisms of attentional control and emotion regulation. The resulting state of consciousness is sometimes described as equanimity. This conceptual review paper explores the process of achieving equanimity within a homeostatic framework. The result is a model of moodfulness, which combines mindfulness with Homeostatically Protected Mood to provide a new theoretical view of recovery from symptoms of depression. This model presents a case for mindfulness restoration of mood homeostasis following homeostatic defeat.