Sound Localization through Multi-Scattering and Gradient-Based Optimization

A gradient-based optimization (GBO) method is presented for acoustic lens design and sound localization. GBO uses a semi-analytical optimization combined with the principle of acoustic reciprocity. The idea differs from earlier inverse designs that use topology optimization tools and generic algorithms. We first derive a formula for the gradients of the pressure at the focal point with respect to positions of a set of cylindrical scatterers. The analytic form of the gradients enhances modeling capability when combined with optimization algorithms and parallel computing. The GBO algorithm maximizes the sound amplification at the focal point and enhances the sound localization by evaluating pressure derivatives with respect to the cylinder positions and then perturbatively optimizing the position of each cylinder in the lens while incorporating multiple scattering between the cylindrical scatterers. The results of the GBO of the uni- and multi-directional broadband acoustic lens designs are presented including several performance measures for the frequency dependence and the incidence angle. A multi-directional broadband acoustic lens is designed to localize the sound and to focus acoustic incident waves received from multiple directions onto a predetermined localization region or focal point. The method is illustrated for configurations of sound hard and sound soft cylinders as well as clusters of elastic thin shells in water.

Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens

Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. However, unfocused ultrasound with MBs (UUS-MBs) and an interchangeable acoustic lens can tune and enhance the pressure field for MB destruction to overcome the disadvantages of FUS-MB DDSs. We designed a lens suitable for an ultrasound-phased array probe and studied the optimal treatment conditions for MB destruction in vitro through an optical imaging setup. The DDS effects were evaluated in a rat hepatoma model using doxorubicin (DOX) treatment. A concave lens with a radius of curvature of 2.6 mm and a thickness of 4 mm was selected and fabricated. UUS-MBs with the acoustic lens at 60 Vpp for 32 cycles and a PRF of 1 kHz could induce MB destruction, promoting the DDS even under fluidic conditions. In the animal experiment, the UUS-MBs in the acoustic lens treatment group had a higher concentration of DOX in the tumor than the control group. Our system suggests uses an acoustic lens to increase DDS effectiveness by providing sufficient ultrasound irradiation to the MBs.

THE USE OF ACOUSTIC WAVES TO SUPPRESS THE COMBUSTION PROCESS IN THE FIRE SEAT

Іn this article, the foundations of the formation of the acoustic method of impact on the combustion center have been considered. The relationship between the parameters of the acoustic impact on the source of an emergency arising from a fire, depending on the burning substance has been established. Separate proposals on the parameters of acoustic impact (power, frequency, pulse shape) and design solutions for acoustic systems for suppressing the combustion process in the fire source at the initial stage of the development of an emergency have been developed. Key words: acoustic method, acoustic impact, combustion process, emergency, acoustic lens.