Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note

PurposeThe safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that are especially sensitive to susceptibility effects from air and blood. LITT for brain tumors is often preceded by a biopsy and is anecdotally associated with artifact during ablation. Thus, we reviewed our experience and describe the qualitative signal dropout that can interfere with ablation.MethodsWe retrospectively reviewed all LITT cases performed in our intraoperative MRI suite for tumors between 2017 and 2020. We identified a total of 17 LITT cases. Cases were reviewed for age, sex, pathology, presence of artifact, operative technique, and presence of blood/air on post-operative scans.ResultsWe identified six cases that were preceded by biopsy, all six had artifact present during ablation, and all six were noted to have air/blood on their post-operative MRI or CT scans. In two of those cases, the artifactual signal dropout qualitatively interfered with thermal damage thresholds at the borders of the tumor. There was no artifact in the 11 non-biopsy cases and no obvious blood or air was noted on the post-ablation scans.ConclusionAdditional consideration should be given to pre-LITT biopsies. The presence of air/blood caused an artifactual signal dropout effect in cases with biopsy that was severe enough to interfere with ablation in a significant number of those cases. Additional studies are needed to identify modifying strategies.

Fast wide-field upconversion luminescence lifetime thermometry enabled by single-shot compressed ultrahigh-speed imaging

Photoluminescence lifetime imaging of upconverting nanoparticles is increasingly featured in recent progress in optical thermometry. Despite remarkable advances in photoluminescent temperature indicators, existing optical instruments lack the ability of wide-field photoluminescence lifetime imaging in real time, thus falling short in dynamic temperature mapping. Here, we report video-rate upconversion temperature sensing in wide field using single-shot photoluminescence lifetime imaging thermometry (SPLIT). Developed from a compressed-sensing ultrahigh-speed imaging paradigm, SPLIT first records wide-field luminescence intensity decay compressively in two views in a single exposure. Then, an algorithm, built upon the plug-and-play alternating direction method of multipliers, is used to reconstruct the video, from which the extracted lifetime distribution is converted to a temperature map. Using the core/shell NaGdF4:Er3+,Yb3+/NaGdF4 upconverting nanoparticles as the lifetime-based temperature indicators, we apply SPLIT in longitudinal wide-field temperature monitoring beneath a thin scattering medium. SPLIT also enables video-rate temperature mapping of a moving biological sample at single-cell resolution.

Surface Temperature Mapping of a Metal Plate using Ultrasound-Guided Wave Technique

Surface temperature mapping is crucial for the monitoring and control of an object of interest, such as furnace, reactor pipes carrying hot fluids, or a component under a temperature dependant process. While the use of waveguides for temperature measurement is well documented in literature, the attachment of the waveguide to a metallic component poses challenges. These include the relationship between the local waveguide temperature and that of the metal component; and wave leakage into the component. In this paper, the authors study the propagation of Shear Horizontal (SH) guided wave in a strip waveguide and its interaction with the notch embodiments in the waveguide. The effects of the type of notch and its depth on the SH mode characteristics are investigated through simulation studies. The mode of attachment of the waveguide to the metal component is by means a slot made in the component. The area of contact between the waveguide and metal component is optimized such that there is minimum wave leakage into the bulk material. Based on the simulation results, a waveguide strip is fabricated and used to monitor the local surface temperature of a test metal component. The waveguide is calibrated by correlating the time of flight shift in the waveforms against reference temperature values. Thereafter, the instantaneous temperature of the metal component is determined from the calibration equations. A set of experimental trials are performed to check for repeatability. The experiments are conducted in near steady-state conditions for better accuracy in the measurements.