The Future of LGBT Politics

This chapter summarizes the role of the U.S. Supreme Court in national policymaking. In the United States there exists a nationally shared set of beliefs, values, and customs, or cultural universals. However, these shared attributes vary according to place and political affiliation. Extending the right to marry to same-sex couples through judicial means precipitated a backlash in which religious groups and individuals turned to legislative solutions to contest the court's decision and their obligation to recognize marriage equality. As the final arbiter of law in the United States, the nine unelected justices of the U.S. Supreme Court play a significant role in policymaking, and their attitudes and decisions regarding policy are tied to the political selection of justices. In the future, decision making from the court to further extend the rights of LGBT citizens may be directly tied to the increasingly partisan selection process for justices.

The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) represent the largest membrane protein family and a significant target class for therapeutics. Receptors from GPCRs’ largest class, class A, influence virtually every aspect of human physiology. About 45% of the members of this family endogenously bind flexible peptides or peptides segments within larger protein ligands. While many of these peptides have been structurally characterized in their solution state, the few studies of peptides in their receptor-bound state suggest that these peptides interact with a shared set of residues and undergo significant conformational changes. For the purpose of understanding binding dynamics and the development of peptidomimetic drug compounds, further studies should investigate the peptide ligands that are complexed to their cognate receptor.

Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms

Rab1 and Rab11 are essential regulators of the eukaryotic secretory and endocytic recycling pathways. The TRAPP complexes activate these GTPases via nucleotide exchange using a shared set of core subunits. The basal specificity of the TRAPP core is towards Rab1, yet the TRAPPII complex is specific for Rab11. A steric gating mechanism has been proposed to explain TRAPPII counterselection against Rab1. Here we present cryoEM structures of the 22-subunit TRAPPII complex from budding yeast, including a TRAPPII-Rab11 nucleotide exchange intermediate. The Trs130 subunit provides a ″leg″ that positions the active site distal to the membrane surface, and this leg is required for steric gating. The related TRAPPIII complex is unable to activate Rab11 due to a repulsive interaction, which TRAPPII surmounts using the Trs120 subunit as a ″lid″ to enclose the active site. TRAPPII also adopts an open conformation enabling Rab11 to access and exit from the active site chamber.

Development of an Approach to Evaluate Website Effectiveness

The internet has been used by individuals, organizations, and governments for business, sports, health, banking, advertisement, education, and other services. Many websites have been developed and designed in the last several decades. However, most have not been developed and designed according to a shared set of design standards. Consequently, there is a need for an approach to evaluate the effectiveness of a website. A literature review was conducted to develop such an approach. Four experts were then consulted to inspect and evaluate the approach, and a questionnaire was completed by three categories: Internet users, website developers, and others to determine its final version. This research resulted in the development of an approach to evaluate website effectiveness, composed of three major criteria: design, content, and functionality, and 17 sub-criteria. The significance of this new approach is that it allows stakeholders to evaluate their websites and determine how to improve them in order to achieve their vision and mission.

Epilogue

Briefly drawing together the main themes of the book in a roundup of ‘lessons learned’, the epilogue sketches out a vision for new forms of group alignment that transcend the parochialism of ancient imagistic worlds and the forms of outgroup derogation and intolerance that doctrinal systems foment, replacing them with new forms of extended fusion. These are required to address all the major challenges of the Anthropocene, including the need to recognize a shared set of human obligations, alongside our much-vaunted rights. As we strive to combat racism and fuel instead the recognition that we are all members of one species, we may also seek to extend that intuition of shared biological essence to all other outgrowths on the tree of life, with which we share a common ancestry. Joining in new rituals that emphasize these sorts of shared experiences and shared bodies will be vital because, in the end, our fates are entwined and the ritual animal is, well, just another animal.

Digital Humanism: Navigating the Tensions Ahead

The assumption of digital humanism that a human-centered approach is possible in the design, use, and further development of AI entails an alignment with human values. If the more ambitious goal of building a good digital society along the co-evolutionary path between humans and the digital machines invented by them is to be reached, inherent tensions need to be confronted. Some of them are the result of already existing inequalities and divergent economic, social, and political interests, exacerbated by the impact of digital technologies. Others arise from the question what makes us human and how our interaction with digital machines changes our identity and relations to each other. If digital humanism is to succeed, a widely shared set of practices and attitudes is needed that sensitize us to the diversity of social contexts in which digital technologies are deployed and how to deal with complex, non-linear systems.

Suggestions for Improving the Investigation of Gesture in Aphasia

Purpose When we speak, we gesture, and indeed, persons with aphasia gesture more frequently. The reason(s) for this is still being investigated, spurring an increase in the number of studies of gesture in persons with aphasia. As the number of studies increases, so too does the need for a shared set of best practices for gesture research in aphasia. After briefly reviewing the importance and use of gesture in persons with aphasia, this viewpoint puts forth methodological and design considerations when evaluating gesture in persons with aphasia. Method & Results We explore several different design and methodological considerations for gesture research specific to persons with aphasia, such as video angle specifications, data collection techniques, and analysis considerations. The goal of these suggestions is to develop transparent and reproducible methods for evaluating gesture in aphasia to build a solid foundation for continued work in this area. Conclusions We have proposed that it is critical to evaluate multimodal communication in a methodologically robust way to facilitate increased knowledge about the relationship of gesture to spoken language, cognition, and to other aspects of living with aphasia and recovery from aphasia. We conclude by postulating future directions for gesture research in aphasia.

Firqa and Iftiraq in Islam

This chapter demonstrates that the classical literature on firqas does not necessarily depict them as social entities, but mostly as groups of scholars with opinions on doctrine. By this definition, Sunnis constituted neither a firqa (sect in the Weberian sense) nor a ta’ifa: Sunnism began as a jurisprudents’ Islam articulated in opposition to what its proponents considered the deviations of a particular historical period. Nor was Sunnism an original, authentic Islam from which all other firqas diverged. This chapter also notes that the term milla referred to all Muslims— expressing a shared set of core beliefs and practices—and that a strong cultural antipathy developed towards disunity, which was identified with decline and fragmentation. This chapter finally emphasizes the anti-sectarian character of Arab secularism.

Against Jazz Combo Theories of Meaning and Reference

The “jazz combo theory” captures the common spirit of various theories that reject reference and the “bottom up” approach to the problem of objective representational content. We can imagine the members of a jazz combo initially playing together without any shared musical norms. But they continually adjust to one another until norms emerge and are mutually endorsed. Players start holding one another to these norms, and it’s this that gives the sounds they produce—what would otherwise be mere noise—determinate musical content. Similarly, on the jazz combo theory, what would otherwise be productions of meaningless strings by language users, come to constitute determinate linguistic acts with determinate propositional contents, by virtue of the users adopting, and holding one another to, a shared set of linguistic and discursive norms. This chapter argues that jazz combo theorists overstate the case against reference, although they’re right in stressing the importance of norms and their dependence on social interaction. Jazz combo theorists tend to reject bottom-up approaches, including causal theories, because they take those approaches to be incompatible with the explanatory priority of the sentence and to fail to bridge the supposed gap between cause and norm. A number of conceptual tools are introduced to counter their arguments and to defend the consistency of the dynamic priority of the sentence, the syntactic correlativity of sentences and their constituents, and the semantic priority of constituents.