Among the great variety of geological relics of Ukraine, one of the most attractive is the Rybalsky Quarry, located in the city of Dnipro, and well known outside Ukraine. First of all, it is famous for the Mandrykivski Layers exposed in one of the ridges of the Quarry back in the 1970s, although there are many other important peculiarities of the geological structure of the Quarry which attract scientists from Ukraine, Germany, France, Netherlands, Russia and other countries. There are full data on the history of discovery and survey of the Mandrykivski Layers from their discovery by Valerian Domger in 1882 to current studies that reveal various aspects of geological structure of the Quarry, the results of study of different groups of fossil fauna, compare them with the fauna of the Paris Upper Eocene basin and other well- known locations. Particularly in the Rybalsky Quarry, thanks to the author`s efforts, the Layers received the status of “layers with geographic name”, as confirmed by the decision of Cenozoic Commission of the National Stratigraphic Committee of Ukraine in 2001. New fragments of the section of subaerial and subaqueous deposits of the Quaternary deposits were found and their composition, structure and complete stratigraphic content were studied. The research allows us to consider it typical for the Middle Prydniprovia. Fluvioglacial and lake-glacial deposits of the Dnipro glaciations in the Quarry exposed for the second time in 25 years, but this is the first time when their genetic origin, position in the section and lithological-facies peculiarities were determined. Thick layer of sands embedded on the roof of the Mandrykivski Layers were identified to the fifth or Hadzhybeiska terrace of the Dnipro, in the upper part of which there were notable siliceous-clayey-ferruginous formations or lateral crust (ferruginous crusts). The studies of the layer of brown-green and red-brown clays in the roof of the Mandrykivski layers allows us to presume their marine origin. In this case, they are underwater weathering crust (terra rossa) developed in the process of halmyrolysis or are the product of dissolution of carbonate silt enriched with detritus of mollusks, corals and other inhabitants of the warm Mandrykivske Sea.