An Analytical Energy Harvester Model for Interdigitated Ring Electrode on Circular Elastic Membrane

Energy harvesters are devices that accumulate ambient vibrational energy from the environment, and for the time being, variable capacitance is the most widely used mechanism. Various designs were proposed to increase the power of such devices, and in particular, the interdigitated electrode (IDE) pattern is the mainstream. Nevertheless, most IDE designs focus merely on the parallel-type vibrations of electrodes. In this study, the performance of a novel harvester, which combined circular membrane and interdigitated ring electrodes (IRE), was investigated. This design allows the device to collect energy from the rotational structure motions of electrodes through the vibrating membrane. Besides, the circular structure provides a dense capacitive arrangement that is higher than that of the arrangement obtained using regular rectangular chips. The IRE diagram is composed of many capacitive rings, each of which harvests vibrated energy simultaneously. Three gaps (1, 10, and 100 μm) of the ring are investigated for the first four vibrational modes of the membrane to understand the effect of energy output. It is found that the energy outputs are approximately the same for the three gaps; however, rings with a wider gap are easier to manufacture in MEMS.

Network Patterns of Zhongyuan Urban Agglomeration in China Based on Baidu Migration Data

As a new product of the Internet and big data era, migration data are of great significance for the revealing of the complex dynamic network patterns of urban agglomerations and for studying the relations between cities by using the “space of flows” model. Based on Baidu migration data of one week in 2021, this paper constructs a 30 × 30 rational data matrix for cities in Zhongyuan Urban Agglomeration and depicts the network pattern from static and dynamic perspectives by using social network analysis and dynamic network visualization. The results show that the network of Zhongyuan Urban Agglomeration is characterized by a circular structure with Zhengzhou as the center, a city belt around Zhengzhou as the connection, subcentral cities as the support and peripheral cities as the extension. Zhengzhou is the core city of the entire network, related to which the central and backbone networks divided in this paper account for nearly 40% of the total migration. Shangqiu, Luoyang, Zhoukou and Handan also play an important role in the structure of the migration network as subcentral cities. For a single city, the migration scale generally peaks on weekends and reaches its minimum during Tuesday to Thursday. Regarding the relations between cities, the migration variation can be divided into four types: peaking on Monday, peaking on weekends, bimodal and stable, and there are obvious phenomena of weekly commuting. In general, the links between cities outside Henan Province and other cities in the urban agglomeration are relatively weak, and the constraints of administrative regionalization on intercity migration are presumed to still exist. According to the results, the location advantage for multi-layer development and construction of Zhongyuan Urban Agglomeration should be made use of. In addition, the status as the core city and the radiation range should be strengthened, and the connections between the peripheral cities and the other cities should be improved, so as to promote the integrated and efficient development of the whole urban agglomeration.

Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors, including gastric cancer (GC). However, there are still many circRNAs related to GC whose functions and molecular mechanisms remain undetermined. Herein, we discover circRNA RELL1, which has not been investigated in GC, and it is markedly downregulated in GC tissues, which is related with poor prognosis, more pronounced lymph node metastasis and poor TNM stage. After confirming the circular structure of circRELL1, we found that circRELL1 could block cell proliferation, invasion, migration, and anti-apoptosis in patients with GC by a series of in vivo and in vitro function-related studies. Further mechanism investigation demonstrated that circRELL1 could sponge miR-637 and indirectly unregulated the expression of EPHB3 via modulating autophagy activation in GC. Additionally, circRELL1 can be transmitted by exosomal communication, and exosomal circRELL1 suppressed the malignant behavior of GC in vivo and in vitro. Taken together, this study elucidates the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in GC progression, inspiring for further understanding of the underlying molecular mechanisms of GC and providing a promising novel diagnostic circulating biomarker and therapeutic target in GC.

Personal Values & Decision-Making Biases

Decision-making is understood to be influenced by genetic and environmental factors related to need, as are personal values. Personal values are a component of personality known to influence decision-making in agreement with the circular structure of the Schwartz (1992) system. We set out to explore whether personal values also exert complementary linear patterns of influence on heuristics and performance in fluid intelligence and creativity tests. Such patterns are predicted by an evolutionary theory that proposes the influence of values described by Schwartz (1992) evolve sequentially and incrementally in living systems, internalising the schema of a pre-existing system of universal equivalents. Testing N=1317 individuals with challenges derived from Kahneman and Tversky and others, we found values exerted both circular and linear influences on intuitive and rational decision-making. These were apparent in overall value/response correlation patterns, and in the performance of individuals allocated to linear, values-based, quasi-Maslowian (1943) motivational types. Performance in fluid intelligence and creativity tests most strongly betrayed linear, developmental patterns of influence. In relation to a Bayesian inference challenge, tentative support was also forthcoming for the hypothesis that those most likely to be subject to values-related conflicts would be most likely to avoid giving erroneous intuitive responses by engaging rational system 2 thinking (Stanovich & West, 2000). This suggests values may also play a role in mediating between rational and irrational systems of thinking. These findings extend our understanding of the role values play in individual decision-making, and by extension, their importance in organizational and societal decision-making.

Permian Ages of “Younger Granites” from Mounio Province (Gouré area, Southeastern Niger)

African formations intruded by the “Younger Granites” ring complex. In the study area, the “Younger Granites” are represented by volcanic to acid plutonic rocks with hyperalkaline trends (pyroclastic rocks, rhyolites, microgranites, granites, syenites), forming in the North, a circular structure called Gouré ring complex. Preliminary geochronological datings of the Mounio granites have yielded Carboniferous ages. However, recent investigations carried out in this province have identified structures similar to Pan-African deformation structures, such as folds and several generations of schistosity/foliation. Analysis of the relationship between deformation and magmatism has removed any ambiguity regarding the relative age of the deformation. This study focuses on the radiometric dating of the “Younger Granites” of Gouré area, in order to update the geochronological data. Thus, three samples (pyroclastitic rock, rhyolite, microgranite) were dated by the K-Ar method on total rock using a mass spectrometertype MI 1201 IG. Radiometric dating results assign a Lower Permian age (293-287 Ma) to the “Younger Granites” Ring Complex of the Mounio Province in Niger, classically considered to be Carboniferous in age.

Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review

This review focuses on the synthesis of current experimental and observational data regarding the effect of fluoride exposure on childhood mental health and the role of mitochondrial function as a mechanism of action. We aggregated data on the relationships between fluoride neurotoxicity, mitochondrial function, and cognitive and mental health using PubMed. Current animal and human research suggest that prenatal and perinatal fluoride exposure might have neurotoxic effects. These studies observed physical changes (fur loss and delayed reflex development in animals), intelligence loss, increased hyperactivity, and irregular moods associated with fluoride exposure. Two gaps in the literature were identified: (1) there is limited research on the mental and emotional impacts of fluoride exposure compared to research on cognitive outcomes, and (2) human studies primarily focus on prenatal and perinatal exposure, with little research conducted at other time points (e.g., adolescence). Furthermore, there is no agreed-upon mechanism for the neurotoxic effects of fluoride; however, fluoride can induce mitochondrial damage, including decreasing circulating mitochondrial DNA content, dysregulating biogenesis, and circular structure loss. Additionally, many neurodevelopmental conditions have mitochondrial underpinnings. More work is needed to elucidate the impact and timing of fluoride exposure on mental health and the role of mitochondrial function as a biological mechanism

On MSE-Optimal Circular Crossover Designs

In crossover designs, each subject receives a series of treatments, one after the other in p consecutive periods. There is concern that the measurement of a subject at a given period might be influenced not only by the direct effect of the current treatment but also by a carryover effect of the treatment applied in the preceding period. Sometimes, the periods of a crossover design are arranged in a circular structure. Before the first period of the experiment itself, there is a run-in period, in which each subject receives the treatment it will receive again in the last period. No measurements are taken during the run-in period. We consider the estimate for direct effects of treatments which is not corrected for carryover effects. If there are carryover effects, this uncorrected estimate will be biased. In that situation, the quality of the estimate can be measured by the mean square error, the sum of the squared bias and the variance. We determine MSE-optimal designs, that is, designs for which the mean square error is as small as possible. Since the optimal design will in general depend on the size of the carryover effects, we also determine the efficiency of some designs compared to the locally optimal design. It turns out that circular neighbour-balanced designs are highly efficient.

Coleridge’s Imperfect Circles

<p>This thesis takes as its starting point Coleridge’s assertion that “[t]he common end of all . . . Poems is . . . to make those events which in real or imagined History move in a strait [sic] Line, assume to our Understandings a circular motion” (CL 4: 545). Coleridge’s so-called “Conversation” poems seem to conform most conspicuously to this aesthetic theory, structured as they are to return to their starting points at their conclusions. The assumption, however, that this comforting circular structure is commensurate with the sense of these poems can be questioned, for the conclusions of the “Conversation” poems are rarely, if ever, reassuring. The formal circularity of these poems is frequently achieved more by persuasive rhetoric than by any cohesion of elements. The circular structure encourages the reader’s expectations of unity and synthesis, but ultimately these expectations are disappointed, and instead the reader is surprised by an ending more troubling than the rhetoric of return and reassurance would suggest. Taking three “Conversation” poems as case studies (“The Eolian Harp,” “This Lime-Tree Bower My Prison,” and “Frost at Midnight”), this thesis attempts to explicate those tensions which exist in the “Conversation” poems between form and effect, between structure and sense.</p>