An Insight to ncovid-19 associated coagulopathy

: Several current studies have highlighted the high occurrence of coagulopathy in nCOVID-19 infection. The corona virus often prompts hypercoagulability along with both microangiopathy and local thrombus development, and systemic coagulation limitation which causes large vessel thrombosis and key thromboembolic issues such as pulmonary embolism in seriously ill hospitalized patients. Based on recent reports, the most severely ill patients present with coagulopathy, and disseminated intravascular coagulation (DIC)-like massive intravascular clot formation is frequently seen in this cohort. Therefore, coagulation tests may be considered useful to discriminate severe cases of nCOVID-19. The clinical presentation of nCOVID-19-associated coagulopathy is organ dysfunction primarily, while hemorrhagic events are less frequent. Changes in hemostatic biomarkers represented by increase in D-dimer and fibrin/fibrinogen degradation products indicate the essence of coagulopathy is massive fibrin formation. Overall, the patients have an increase in venous and arterial thrombotic events especially in ICU patients. Routine thromboprophylaxis with low molecular weight heparin is recommended in all hospitalized patients to reduce the incidence of thrombosis. Though, the importance of thromboembolic impediments has not been extensively spotlighted, thus the rationale of this article is to provide recent information about this severe difficulty. In this article the mechanism of coagulopathy, associated problems and possible therapeutics has been reviewed.

Assessment of Sleep Habits and Quality of Sleep among Elderly Residing in Rural Areas of Patiala: A Community-Based Cross-Sectional Survey

INTRODUCTION: Among the elderly, sleep problems are quite prevalent and can lead to many adverse health consequences. AIM: To assess the quality of sleep among the elderly residing in rural population and factors related to it, and provide necessary recommendations for its prevention. MATERIALS AND METHOD: In this cross-sectional study, elderly aged above 60 years residing in Patiala were taken and were interviewed separately using the modified version of the Pittsburgh Sleep Quality Index (PSQI), which was pre-tested and pre-validated prior to commencement of the study. Data recorded was divided into seven components and each component had an individual range of 0 (no difficulty) to 3 (severe difficulty) points and added to obtain a combined score of the individual with a range of 0(no difficulty)-21(severe difficulty) points. Based on the combined score, elderly obtaining a total score of 5 or greater was classified as having “poor sleep quality”. Statistics were applied using SPSS version 22.0, using the student’s t- test, and multivariate analysis. A p value < 0.05 was considered as significant. RESULTS: Out of 108 elderly people, most of the participants (62.9%) belonged to the age group of 60-75 years, out of which the majority (65.7%) were males. Most elderly reported having “fairly good” subjective sleep quality (53.7%, p=0.01) and was found to be significant with a global PQSI score of 7.22±4.31. Multivariate analysis revealed that significant “poor sleep quality” was observed in elderly aged above 75 years (OR:1.25, p=0.01) followed by elderly who were Immobilized (wheelchair/Bed ridden) (OR: 1.87, p=0.01). CONCLUSION: Efforts should be directed towards proper education of not only the elderly, but their children as well as colleagues and guardians to improve the sleep score of the elderly population.

Face Perception Deficits in Developmental Prosopagnosia

<p>Face recognition is a fundamental cognitive function that is essential for social interaction – yet not everyone has it. Developmental prosopagnosia is a lifelong condition in which people have severe difficulty recognising faces but have normal intellect and no brain damage. Despite much research, the component processes of face recognition that are impaired in developmental prosopagnosia are not well understood. Two core processes are face perception, being the formation of visual representations of a currently seen face, and face memory, being the storage, maintenance, and retrieval of those representations. Most studies of developmental prosopagnosia focus on face memory deficits, but a few recent studies indicate that face perception deficits might also be important. Characterising face perception in developmental prosopagnosia is crucial for a better understanding of the condition. In this thesis, I addressed this issue in a large-scale experiment with 108 developmental prosopagnosics and 136 matched controls. I assessed face perception abilities with multiple measures and ran a broad range of analyses to establish the severity, scope, and nature of face perception deficits in developmental prosopagnosia. Three major results stand out. First, face perception deficits in developmental prosopagnosia were severe, and could be comparable in size to face memory deficits. Second, the face perception deficits were widespread, affecting the whole sample rather than a subset of individuals. Third, the deficits were mainly driven by impairments to mechanisms specialised for processing upright faces. Further analyses revealed several other features of the deficits, including the use of atypical and inconsistent strategies for perceiving faces, difficulties matching the same face across different pictures, equivalent impact of lighting and viewpoint variations in face images, and atypical perceptual and non-perceptual components of test performance. Overall, my thesis shows that face perception deficits are more central to developmental prosopagnosia than previously thought and motivates further research on the issue.</p>

Face Perception Deficits in Developmental Prosopagnosia

<p>Face recognition is a fundamental cognitive function that is essential for social interaction – yet not everyone has it. Developmental prosopagnosia is a lifelong condition in which people have severe difficulty recognising faces but have normal intellect and no brain damage. Despite much research, the component processes of face recognition that are impaired in developmental prosopagnosia are not well understood. Two core processes are face perception, being the formation of visual representations of a currently seen face, and face memory, being the storage, maintenance, and retrieval of those representations. Most studies of developmental prosopagnosia focus on face memory deficits, but a few recent studies indicate that face perception deficits might also be important. Characterising face perception in developmental prosopagnosia is crucial for a better understanding of the condition. In this thesis, I addressed this issue in a large-scale experiment with 108 developmental prosopagnosics and 136 matched controls. I assessed face perception abilities with multiple measures and ran a broad range of analyses to establish the severity, scope, and nature of face perception deficits in developmental prosopagnosia. Three major results stand out. First, face perception deficits in developmental prosopagnosia were severe, and could be comparable in size to face memory deficits. Second, the face perception deficits were widespread, affecting the whole sample rather than a subset of individuals. Third, the deficits were mainly driven by impairments to mechanisms specialised for processing upright faces. Further analyses revealed several other features of the deficits, including the use of atypical and inconsistent strategies for perceiving faces, difficulties matching the same face across different pictures, equivalent impact of lighting and viewpoint variations in face images, and atypical perceptual and non-perceptual components of test performance. Overall, my thesis shows that face perception deficits are more central to developmental prosopagnosia than previously thought and motivates further research on the issue.</p>

Difficulties of Young Adults With Dyslexia in Reading and Writing Numbers

Letters and numbers are different domains, and their differentiation increases with schooling. It has nonetheless been argued that reading alphabetic and numerical materials partly involves the same processes, even in adults. Whether individuals with dyslexia have difficulty reading and writing numbers remains to be established. This study examined this issue in a group of 30 young adults with a diagnosis of dyslexia, without any concurrent specific difficulty in processing quantities compared with a typically developing group matched for gender, age, university attended and course of studies, and approximate calculation ability. The results showed that adults with dyslexia also have severe difficulty in reading and writing numbers. It emerged that their number reading speed correlated moderately with word reading speed. We concluded that dyslexia is specifically related with difficulties in reading and writing not only alphabetic material, but also numerical material. Our findings suggest that these abilities should be considered more carefully when assessing and supporting individuals with dyslexia.

Rare Case of a Schwannoma of the Posterior Pharyngeal Wall in a Child

We present a rare case of a schwannoma which is localized on the posterior pharyngeal wall. It caused severe difficulty in swallowing and breathing in a 3-year-old child. Schwannomas of the posterior pharyngeal wall have been rarely reported in children. To our knowledge, only 7 cases of posterior pharyngeal wall schwannoma have been previously reported in the literature, but none of them is associated with a child. The tumor was removed with plasma radiofrequency excision via a transoral route. Computed tomography or magnetic resonance imaging examination showed no recurrence of the tumor up to 2 years. To our knowledge, for the first time, a case of posterior pharyngeal wall schwannoma has been reported in a 3-year-old child, and the schwannoma was removed via plasma radiofrequency transoral excision. This case study illustrates that schwannoma may occur in children, and it is safe to treat this disease through plasma radiofrequency transoral excision route.

A Pioneering Physiotherapeutic Approach to the Treatment of a COVID Affected Patient – A Case Report

The Coronavirus (SARS-CoV-19) originated from Wuhan, China and has affected globe since 2019. The virus spread to India in January, 2020. It is highly contagious. In its severe form, the victims of the virus suffered from symptoms such as breathing difficulties, fever, weakness, loss of taste and smell, amongst others. Patients were put on mechanical ventilators and as a result, the requirement of the role of cardio-respiratory physiotherapists became more and more essential. Even after weaning off from the ventilators and being detected Coronavirus negative, the role of the physiotherapists still remained indispensable in order to bring about improvement in the muscle strength of the affected weakened muscles, especially for patients whose movements were limited for extended periods of times due to being dependent on the ventilators; physiotherapists were also required to bring about improvement in the lung capacities and function, to teach gait training for those who find it difficult to walk, to improve in-coordination and overall allow the patients to come back to normal and carry out all the ADL independently and well. He had a severe difficulty in breathing and coughing, along with a generalized weakness all over his body, specifically both his lower limbs. He was admitted in the ICU immediately and was on mechanical ventilator. After all the physiotherapy sessions, the patient was able to carry out his activities of daily living independently; he regained his muscle strength and improved his coordination and ability to walk with a proper gait. He was also able to breathe independently with adequate respiratory muscle strength; and did not feel fatigued as quickly as he used to when he was detected positive for Coronavirus.

Schwannoma of the Posterior Pharyngeal Wall in a Child

Background: To our knowledge, There are only 7 cases of posterior pharyngeal wall schwannoma which have been previously reported in the literature, but none of them was associated with a 3-year-old child.Case presentation: We presented a rare case of a schwannoma which is localized on the posterior pharyngeal wall, It caused severe difficulty in swallowing and breathing in a child whose age is three years old. Schwannomas of the posterior pharyngeal wall has been rarely reported in children, The tumor was removed with plasma radio frequency excision via a transoral route, There was not seen any recurrence of tumor by examination of CT or MRI up to two years. as far as we know, It's the first time which a case of posterior pharyngeal wall schwannoma that has been reported to occur in a 3-year-old child, and the first case in which the schwannoma was removed via transoral plasma radio frequency excision.Conclusions: This case illustrates that schwannoma may be found in children ,and it is safe to treat this disease through plasma radio frequency excision via a transoral route.

Schwannoma of the posterior pharyngeal wall in a child

Background: To our knowledge, There are only 7 cases of posterior pharyngeal wall schwannoma which have been previously reported in the literature, but none of them was associated with a 3-year-old child.Case presentation: We presented a rare case of a schwannoma which is localized on the posterior pharyngeal wall, It caused severe difficulty in swallowing and breathing in a child whose age is three years old. Schwannomas of the posterior pharyngeal wall has been rarely reported in children, The tumor was removed with plasma radio frequency excision via a transoral route, There was not seen any recurrence of tumor by examination of CT or MRI up to two years. as far as we know, It's the first time which a case of posterior pharyngeal wall schwannoma that has been reported to occur in a 3-year-old child, and the first case in which the schwannoma was removed via transoral plasma radio frequency excision.Conclusions: This case illustrates that schwannoma may be found in children ,and it is safe to treat this disease through plasma radio frequency excision via a transoral route.

Prevalence of Musculoskeletal Disorder of Upper Limb In Gardeners of Pakistan Horticulture Authority

For non-lethal professional traumas, the most prevailing injuries were nonfatal and ailment every year. However, for the fitness care and community based job occupation, half of the total absence because of ailment is reported at jobor due to job. Objective: To determine the Prevalence of Musculoskeletal Disorder of Upper Limb in Gardeners of PHA. Methodology: An observational study conducted Dash and VAS questionnaire used for the study. Data collected from gardeners of PHA. Participants participated voluntarily by completing a questionnaire with excellent reliability. The questionnaire contained many items to evaluate problems in shoulder, elbow and hand. The duration of the study were 4 months after approval of synopsis. A sample technique was convenient sample technique result analyzedwith SPSS version 21.Results: 185 participants are selected for study. Data collected from PHA gardeners.50 (23.9%)reported with severe difficulty that was highest frequency reported for severe difficulty while doing garden work in gardeners. Moderate difficulty reported with high frequency in gardeners while carrying heavy objects. Workactivities reported like hammering with high frequency of inability to perform this activity due to disability.it is also reported that gardeners are very limited in work .high frequency reported in severity of symptoms in shoulder,arm and hands in gardeners Conclusions: This study indicates gardeners are direct sufferers of musculoskeletal disorders with pain symptoms in shoulder, arm and hands.VAS scale measures showing upper limb disorderssymptoms are producing limitations in daily work.