Photo-triggered Zn2+ release for regulation of zinc enzymes

Zinc ion (Zn2+) plays a critical role in regulation of zinc enzymes and cell metabolism. However, the previous Zn2+ delivery methods are usually based on pH-responsive zinc coordination complexes, which...

Zinc and Psychiatric Disorders: A Review

Zinc is one of the micronutrients involved in emotional, cognitive, and behavioural processes. Zinc deficiency is considered to impact mental well-being, with varying degrees of anxiety and stress, consistent with zinc enzymes having important activity in brain growth and functional behaviour. Zinc is a neurosecretory substance or cofactor and is hugely abundant in particular neuron contingent named zinc-containing neurons' synaptic vesicles. The concentration of zinc in the vesicles is estimated to reach 1mmol / L and is just mildly associated with some endogenous ligand. Zinc comprising neurons is located primarily in the forebrain, where primates have evolved into a dynamic and intricate network of connections that interconnect much of the cerebral corticles and limbic structures. Changes in the homeostasis of zinc can be linked with brain disease and inflammatory activity of the brain. Zinc ion dyshomeostasis can also play a function in the ageing neurons as synapses deteriorate. Hence, a greater understanding of the function of zinc in the central nervous system may enable therapeutic strategies to be established where aberrant metal homeostasis is involved in the pathogenesis of the disease.

Manfaat aloe vera sebagai terapi topikal luka bakar

Aloe vera is an herbal plant that has been used extensively for centuries as a natural medicine. Aloe vera therapy activities can be used to treat skin lesions, such as burns. The gel has healing, analgesic, and anti-inflammatory activity, besides being a powerful moisturizing and protective skin agent. The speed of healing in the aloe vera group is better than the conventional group. Effects produced by aloe vera gel with reference to wound contraction, wound closure, decrease in wound surface area, tissue regeneration at the wound site. Aloe vera contains important nutrients such as vitamins A, C and E, which act as antioxidants, minerals (calcium, copper, magnesium, potassium, and zinc), enzymes, glycoproteins, amino acids, carbohydrate constituents, such as polysaccharides and salicylic acids

Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma

Zinc plays a pivotal role in various zinc enzymes, which are crucial in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. Whether long-term zinc supplementation improves liver function and reduces the risk of hepatocellular carcinoma (HCC) development remains unknown. Two hundred and sixty-seven patients with CLDs who received a zinc preparation (Zn-group; 196 patients), or who did not receive zinc (no Zn-treatment group; 71 patients), were retrospectively analyzed in this study. The Zn-group was divided into 4 groups according to their serum Zn concentrations at 6 months after the start of Zn treatment. Liver function significantly deteriorated in the no Zn-treatment group, while no notable change was observed in the Zn-group. The cumulative incidence rates of events and HCC at 3 years were observed to be lower in the Zn-group (9.5%, 7.6%) than in the no Zn-treatment group (24.9%, 19.2%) (p < 0.001). According to serum Zn concentrations, the cumulative incidence rates of events and HCC were significantly decreased in patients with Zn concentrations ≥ 70 µg/dL (p < 0.001). Zinc supplementation appears to be effective at maintaining liver function and suppressing events and HCC development, especially among patients whose Zn concentration is greater than 70 µg/dL.

Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma

Background and Aim: Zinc plays a pivotal role in various zinc enzymes, resulting in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. It remains unknown whether long-term zinc supplementation improves liver function and reduces the risk of hepatocellular carcinoma (HCC) development. Patients and Methods: Two hundred sixty-seven patients with CLDs who received a zinc preparation (Zn-group; 196 patients), or who did not receive zinc (no Zn-treatment group; 71 patients) were retrospectively analyzed in this study. The Zn-group was divided into 4 groups according to their serum Zn concentrations at 6 months after the start of Zn treatment. Results: Liver function significantly deteriorated in the no Zn-treatment group, while no notable change was observed in the Zn-group. The cumulative incidence rates of events and HCC at 3 years were lower in the Zn-group (9.5%, 7.6%) than in the no Zn-treatment group (24.9%, 19.2%) (p&lt;0.001). According to the serum Zn concentrations, the cumulative incidence rates of events and HCC were significantly decreased in patients with Zn concentrations &ge; 70 &micro;g/dl (p&lt;0.001). Conclusion: Zinc supplementation appears to be effective at maintaining liver function and suppressing events and HCC development, especially among patients whose Zn concentration is greater than 70 &micro;g/dl.

Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

Rapid metal exchange in anthrax lethal factor and potentially other zinc enzymes proceeds via the formation of transient bimetallic species.