Providing supportive end-of-life care is an essential component of critical care. Intensivists require excellent communication skills to convey painful information in a compassionate manner and to assist families in making difficult decisions. Both aggressive life-supporting treatment and care following a decision to withdraw or withhold life-support require attention to providing adequate comfort care, including relief of pain, anxiety, delirium, agitation, nausea, and other gastrointestinal complaints. Understanding the use of a variety of drugs, including their interactions and side effects, as well as nonpharmacological therapies, is essential. Following a decision to withdraw life support, intensivists should develop a plan that is clear to other care providers and families, minimizes further interventions, and provides as much privacy as possible. After a child dies, numerous tasks must be completed; most important among them are offering parents an opportunity for follow-up support and giving involved staff members time to gather their thoughts and feelings.