The Molecular Landscape of Medulloblastoma in Teenagers and Young Adults

Medulloblastoma (MB) is a childhood malignant brain tumour but also occurs in teenagers and young adults (TYA). Considering that MB is heterogeneous, this study aimed to define the molecular landscape of MBs in TYAs. We collated more than 2000 MB samples that included 287 TYA patients (13–24 years). We performed computational analyses consisting of genome-wide methylation and transcriptomic profiles and developed a prognostics model for the TYAs with MB. We identified that TYAs predominantly comprised of Group 4 (40%) and Sonic Hedgehog (SHH)-activated (33%) tumours, with Wingless-type (WNT, 17%) and Group 3 (10%) being less common. TYAs with SHH tumours displayed significantly more gene expression alterations, whereas no gene was detected in the Group 4 tumours. Across MB subgroups, we identified unique and shared sets of TYA-specific differentially methylated probes and DNA-binding motifs. Finally, a 22-gene signature stratified TYA patients into high- and low-risk groups, and the prognostic significance of these risk groups persisted in multivariable regression models (P = 0.001). This study is an important step toward delineating the molecular landscape of TYAs with MB. The emergence of novel genes and pathways may provide a basis for improved clinical management of TYA with MB.

Genetic polymorphism of opioid receptors and use of opioid substances by high school students of Cotonou and Parakou (Benin)

In Benin, schools become sometimes the hub for dealing and consuming psychoactive substances; opioids in particular. The objectives of this study are to identify the risk factors related to the use of opioids and investigate the genetic polymorphism of mu and delta opioid receptors of teenagers and young adults who consume opioids in schools. To accomplish this, 453 students participated in this study; R diversity 3.6.1 software in the RStudio environment was used to identify students who experience opioids through ASSIST V3.0 scoring. SNPs A118G on the OPRM gene (µ) and T921C on the OPRD gene (d), were searched by PCR on DNA extracts from peripheral blood of individuals. We identified 54 regular opioid users and 399 non users. This experience begins for most with the consumption of alcohol and tobacco and is facilitated by the proximity of marshlands, kiosks, and pubs near high schools and colleges. The aggressive advertisement combined with relative socio-cultural tolerance just worsen this behavioral deviance. We found no difference in the SNP frequencies of the OPRM (µ) and OPRD (d) genes between students opioids consumers and non-consumers.

Exploring Stress and Problematic Use of Short-Form Video Applications among Middle-Aged Chinese Adults: The Mediating Roles of Duration of Use and Flow Experience

The pervasiveness of smartphones and the popularity of short-form video applications (SVAs), such as TikTok, among middle-aged Chinese adults have raised concerns about problematic SVAs use. Although a plethora of research has examined problematic smartphone use among teenagers and young adults, scarce attention has been paid to the middle-aged group. This study integrates the psychopathological approach and the compensatory use approach to explicate problematic SVAs use among middle-aged Chinese adults. We aim to examine the relationship between stress and problematic SVAs use via the mediating roles of duration of use and flow experience. A total of 194 middle-aged adults from across the nation participated in an online survey. The results showed that stress was positively associated with problematic SVAs use. We also found that duration of use positively mediated the relationship between stress and problematic SVAs use. Furthermore, a serial mediation effect of duration of use and flow experience was found. The findings suggest that the aforementioned two approaches are complementary to each other in explicating problematic SVAs use, but the compensatory use approach explains more than the psychopathological approach does. Flow experience extends the original compensatory use approach and demonstrates the importance of incorporating techno-psychological predictors in understanding problematic SVAs use.

When the Family Occupies the Future – Self-Processes and Well-Being of Kyrgyz Children and Young People

The paper focuses on the question of how young people in the post-Soviet country of Kyrgyzstan deal with the structural and cultural demands of a society characterized by strong obligations of intergenerational solidarity and the normative pattern of submission under the authority of elders. Based on three preponderantly qualitative empirical studies on kindergarten children, teenagers and young adults, young people’s commitment to that order is mapped out, defining their reasons for acceptance on the one hand and the limits of their acceptance on the other hand. Concerning the latter, a special focus is laid on processes of the “self” as well as notions of a “generation gap”. We can then deduce what the hierarchical age order means for the well-being of young people.

English Language Butchered: A Study of the Correlational Relationship Between Text Messaging Frequency and the Instance of Jargon in Formal Writing

<p>The rapidly evolving text messaging phenomenon among teenagers and young adults is noteworthy. This study was designed to investigate the relationship between text messaging frequency and use of text messaging jargon in formal writing. The sample consisted of 152 Year 11-13 secondary school students (68 males and 84 females) ranging from ages 14 to 18. The participants were taken from three Secondary Schools and Colleges in the greater Wellington area. This study used a non-experimental quantitative design; specifically, a correlational research design. A ten- item questionnaire was used to assess general text messaging behaviours and text messaging frequency. The participants‘ formal writing pieces were also assessed and text messaging jargon forms such as alternative phonetic spelling, vowel deletion and alphanumerisms were identified. The participants‘ language ability (represented by their NCEA scores for the previous year) was also assessed. The results revealed that the participants sent an average of 95 text messages per day with girls averaging about 126 messages per day while the boys averaged 64 messages per day. Overall, the research revealed that there was a weak negative correlational relationship (-0.01; p=.986) between frequency of text messaging and instance of text jargon in formal writing. Therefore, the principal conclusion of the study was that the two variables, frequency of text messaging and instance of jargon in formal writing were not statistically related.</p>

English Language Butchered: A Study of the Correlational Relationship Between Text Messaging Frequency and the Instance of Jargon in Formal Writing

<p>The rapidly evolving text messaging phenomenon among teenagers and young adults is noteworthy. This study was designed to investigate the relationship between text messaging frequency and use of text messaging jargon in formal writing. The sample consisted of 152 Year 11-13 secondary school students (68 males and 84 females) ranging from ages 14 to 18. The participants were taken from three Secondary Schools and Colleges in the greater Wellington area. This study used a non-experimental quantitative design; specifically, a correlational research design. A ten- item questionnaire was used to assess general text messaging behaviours and text messaging frequency. The participants‘ formal writing pieces were also assessed and text messaging jargon forms such as alternative phonetic spelling, vowel deletion and alphanumerisms were identified. The participants‘ language ability (represented by their NCEA scores for the previous year) was also assessed. The results revealed that the participants sent an average of 95 text messages per day with girls averaging about 126 messages per day while the boys averaged 64 messages per day. Overall, the research revealed that there was a weak negative correlational relationship (-0.01; p=.986) between frequency of text messaging and instance of text jargon in formal writing. Therefore, the principal conclusion of the study was that the two variables, frequency of text messaging and instance of jargon in formal writing were not statistically related.</p>

Specialist cancer services for teenagers and young adults in England: BRIGHTLIGHT research programme

Background When cancer occurs in teenagers and young adults, the impact is far beyond the physical disease and treatment burden. The effect on psychological, social, educational and other normal development can be profound. In addition, outcomes including improvements in survival and participation in clinical trials are poorer than in younger children and older adults with similar cancers. These unique circumstances have driven the development of care models specifically for teenagers and young adults with cancer, often focused on a dedicated purpose-designed patient environments supported by a multidisciplinary team with expertise in the needs of teenagers and young adults. In England, this is commissioned by NHS England and delivered through 13 principal treatment centres. There is a lack of evaluation that identifies the key components of specialist care for teenagers and young adults, and any improvement in outcomes and costs associated with it. Objective To determine whether or not specialist services for teenagers and young adults with cancer add value. Design A series of multiple-methods studies centred on a prospective longitudinal cohort of teenagers and young adults who were newly diagnosed with cancer. Settings Multiple settings, including an international Delphi study of health-care professionals, qualitative observation in specialist services for teenagers and young adults, and NHS trusts. Participants A total of 158 international teenage and young adult experts, 42 health-care professionals from across England, 1143 teenagers and young adults, and 518 caregivers. Main outcome measures The main outcomes were specific to each project: key areas of competence for the Delphi survey; culture of teenagers and young adults care in the case study; and unmet needs from the caregiver survey. The primary outcome for the cohort participants was quality of life and the cost to the NHS and patients in the health economic evaluation. Data sources Multiple sources were used, including responses from health-care professionals through a Delphi survey and face-to-face interviews, interview data from teenagers and young adults, the BRIGHTLIGHT survey to collect patient-reported data, patient-completed cost records, hospital clinical records, routinely collected NHS data and responses from primary caregivers. Results Competencies associated with specialist care for teenagers and young adults were identified from a Delphi study. The key to developing a culture of teenage and young adult care was time and commitment. An exposure variable, the teenagers and young adults Cancer Specialism Scale, was derived, allowing categorisation of patients to three groups, which were defined by the time spent in a principal treatment centre: SOME (some care in a principal treatment centre for teenagers and young adults, and the rest of their care in either a children’s or an adult cancer unit), ALL (all care in a principal treatment centre for teenagers and young adults) or NONE (no care in a principal treatment centre for teenagers and young adults). The cohort study showed that the NONE group was associated with superior quality of life, survival and health status from 6 months to 3 years after diagnosis. The ALL group was associated with faster rates of quality-of-life improvement from 6 months to 3 years after diagnosis. The SOME group was associated with poorer quality of life and slower improvement in quality of life over time. Economic analysis revealed that NHS costs and travel costs were similar between the NONE and ALL groups. The ALL group had greater out-of-pocket expenses, and the SOME group was associated with greater NHS costs and greater expense for patients. However, if caregivers had access to a principal treatment centre for teenagers and young adults (i.e. in the ALL or SOME groups), then they had fewer unmet support and information needs. Limitations Our definition of exposure to specialist care using Hospital Episode Statistics-determined time spent in hospital was insufficient to capture the detail of episodes or account for the variation in specialist services. Quality of life was measured first at 6 months, but an earlier measure may have shown different baselines. Conclusions We could not determine the added value of specialist cancer care for teenagers and young adults as defined using the teenage and young adult Cancer Specialism Scale and using quality of life as a primary end point. A group of patients (i.e. those defined as the SOME group) appeared to be less advantaged across a range of outcomes. There was variation in the extent to which principal treatment centres for teenagers and young adults were established, and the case study indicated that the culture of teenagers and young adults care required time to develop and embed. It will therefore be important to establish whether or not the evolution in services since 2012–14, when the cohort was recruited, improves quality of life and other patient-reported and clinical outcomes. Future work A determination of whether or not the SOME group has similar or improved quality of life and other patient-reported and clinical outcomes in current teenage and young adult service delivery is essential if principal treatment centres for teenagers and young adults are being commissioned to provide ‘joint care’ models with other providers. Funding This project was funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research programme and will be published in full in Programme Grants for Applied Research; Vol. 9, No. 12. See the NIHR Journals Library website for further project information.

The results of a study of the properties of oral fluid in teenagers and young adults who smoke

It is known that smoking is one of the current social and medical problems of today, a proven cause of many serious diseases — a risk factor for more than 20 diseases, which account for almost 75% of the causes of mortality (cancer, cardiovascular, respiratory, dental, etc.). Ukraine ranks 17th in the world in terms of cigarette consumption. It is worrying that this bad habit is very common among children and adolescents, because adolescence is crucial in terms of worldview, life values, attitudes to bad habits, including smoking. More than 500 000 young people join this bad habit every year. It has been established that the components of tobacco smoke affect the mucous membrane of the oral cavity both directly and indirectly — toxic substances enter the salivary glands with the bloodstream and are excreted with saliva in the oral cavity. Changes in oral fluid may be the first signs of disease caused by a bad habit. Oral fluid can act as a diagnostic indicator that reflects the condition of the organs of the oral cavity and the whole body, as well as to predict the course of the disease, to assess the effectiveness of treatment. Purpose — to study the properties of oral fluid in in teenagers and young adults who smoke. Materials and methods. The properties of oral fluid (rate of salivation, pH, buffer capacity and viscosity of oral fluid) in 114 adolescents and adolescents aged 15 to 24 years, which were divided into groups: Group I included 26 people who regularly smoke traditional cigarettes; in group II — 22 people who regularly smoke electronic cigarettes (Weipi); in group III — 23 people who regularly smoke tobacco heating devices (IQOS); in group IV — 43 people, without a bad habit of smoking. Results. When studying the properties of oral fluid in adolescents and young adults, the dependence of its indicators on the presence of a bad habit and type of smoking was revealed. Adolescents and adolescents who smoke both traditional and alternative types of cigarettes in the oral cavity have a decrease in the level of functional reactions that are responsible for the homeostasis of the oral cavity and depend on the type of cigarettes. Analysis of changes in the biophysical parameters of oral fluid indicate a decrease in the level of functional reserves of the oral cavity. Conclusions. Тeenagers and young adults who smoke have changes in the biophysical parameters of oral fluid. Oral fluids can be an early prognostic test to assess the condition of the oral cavity in adolescents and adolescents who smoke. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: oral fluid, biophysical indicators, teenager, young adult, smoking.