Alternative to Reduced Stresses on the Upper Extremity in a Standing Workstation

Objective This study evaluated a standing armrest to provide more acceptable ergonomic guidelines that may reduce the cost of standing computer workstations. Background Of the many advantages of standing workstations, there have been no efforts to minimize the biomechanical cost, such as larger wrist extension and greater forearm muscle activity than sitting. Method Sixteen participants were asked to perform a typing task under a combination of the following factors: (1) desk shape (rectangular and concave); (2) desk height (0, +5, -5 cm from 90° elbow flexion); and (3) monitor height (0, −10 cm from the eyes). During the trials, the trunk kinematics, muscle activation levels, and CoP were recorded. Results Both arms were further away from the upper body under the concave and +5 desk height than under the normal condition, but significant decreases in the extensor carpi radialis (8.6%), anterior deltoid (28.8%), and L4 paraspinals (5.5%) were observed. Similarly, the wrist extension angle decreased by 10.5° (42%) under this condition, but the posture required a 2.2° (19%) increase in wrist adduction angle. The CoP irregularity was greater under the concave workstation, indicating more complex motion. Conclusion A higher and concave desk can provide an armrest effect while engaged in a standing workstation by reducing the wrist extension and related muscle activation level, but at the cost of a larger wrist adduction angle. Application Providing a standing armrest (+5 cm height and concave desk) could reduce the stresses on the upper extremities, but a split keyboard should be considered to minimize wrist adduction.

Positive Psychology, Activation, and Self-Care Adherence in a Diverse Sample of Adults With Heart Failure

Heart failure (HF) self-care is vital to health and wellbeing, yet more than half of all persons with HF do not adhere to the self-care recommendations of taking medications as prescribed, weighing daily, eating low salt foods, or exercising. It has been suggested that disparities in HF among racial/ethnic groups may be reflective of underlying determinants of health, such as poor engagement in self-care activities, rather than genetic or physiological differences. The purpose of this study was to examine direct and indirect effects of perceived social support, positive psychological (PP) characteristics, and patient activation on self-care behaviors in a diverse sample of older adults with HF. A nationwide survey was conducted in cooperation with the recruitment and sampling company Qualtrics. Stratified random sampling was used where 49% of the 174 respondents were persons of color (POC). The mean age was 60. Logistic regression statistical models were used with a lasso procedure. In this study, PP characteristics and activation level were most predictive of HF self-care adherence, particularly medication adherence. Respondents who were resilient, hopeful, and activated also reported higher medication and self-care adherence. Perceived social support and health literacy levels were not associated with self-care adherence. There were no differences in predictive variables by race/ethnicity, gender, or age. Interventions aimed at increasing resilience, hope, and engagement in care or activation may improve HF self-care adherence among persons with HF. Further research is needed to understand the impact of PP characteristics and patient activation level on HF self-care adherence in POC.

The impact of music therapy in late-moderate premature infants, on their parents and their environment, in a Spanish neonatal intermediate care unit.

The aim of this study is to determine whether a live music therapy session during parent holding had an effect on physiological and comfort outcomes of late-moderate preterm infants, on their parents, and on the ward environment. This is a quasi-experimental study of a cohort of 44 preterm / adult pairs exposed to a music therapy session in the first two weeks after birth. There were 3 moments of observation (before, during, and after the intervention), at which heart rate (HR), oxygen saturation (O2-sat), the infant’s behavioral-emotional activation level, and the environmental response were measured. A statistically significant increase was observed in O2-sat (p<.001) after the intervention, as well as a decrease in HR (p<.001). Personal and environmental stress was observed to decrease (p<.001). A music therapy session in the Neonatal Unit at the time of interaction between parents and premature infants was found to be useful in reducing stress and promoted a positive interaction between parents and infants.

FOXA1: A Pioneer of Nuclear Receptor Action in Breast Cancer

The pioneering function of FOXA1 establishes estrogen-responsive transcriptomes in luminal breast cancer. Dysregulated FOXA1 chromatin occupancy through focal amplification, mutation, or cofactor recruitment modulates estrogen receptor (ER) transcriptional programs and drives endocrine-resistant disease. However, ER is not the sole nuclear receptor (NR) expressed in breast cancers, nor is it the only NR for which FOXA1 serves as a licensing factor. Receptors for androgens, glucocorticoids, and progesterone are also found in the majority of breast cancers, and their functions are also impacted by FOXA1. These NRs interface with ER transcriptional programs and, depending on their activation level, can reprogram FOXA1-ER cistromes. Thus, NR interplay contributes to endocrine therapy response and resistance and may provide a vulnerability for future therapeutic benefit in patients. Herein, we review what is known regarding FOXA1 regulation of NR function in breast cancer in the context of cell identity, endocrine resistance, and NR crosstalk in breast cancer progression and treatment.

Explaining the efficacy of an internet-based behavioral activation intervention for major depression: A mechanistic study of a randomized-controlled trial

Background Behavioral activation is an effective treatment for depression that is theorized to facilitate structured increases in enjoyable activities that increase opportunities for contact with positive reinforcement; to date, however, only few mechanistic studies focused on a standalone intervention. Method Interventions using internet-based behavioral activation or psychoeducation were compared based on data from a randomized-controlled trial of 313 patients with major depressive disorder. Activation level and depression were measured fortnightly (baseline, Weeks 2, 4, 6, 8, 10), using the Patient Health Questionnaire-9 and the Behavioral Activation for Depression Scale-Short Form, respectively. Analysis was performed to determine if a change in activation level mediated treatment efficacy. Results Latent growth modeling showed that internet-based behavioral activation treatment significantly reduced depressive symptoms from baseline to the end of treatment (standardized coefficient = −.13, p = .017) by increasing the rate of growth in the activation level (mediated effect estimate = −.17, 95% CI [−.27, −.07]. Results from mixed effects and simplex models showed that it took 4 weeks before mediation occurred (i.e., a significant change in activation that led to a reduction in depressive symptoms). Conclusion Activation level likely mediated the therapeutic effect of behavioral activation on depression in our intervention. This finding may be of significant value to clinicians and depressed individuals who should anticipate a 4-week window before seeing a prominent change in activation level and a 6-week window before depressive symptomatology reduces. Future research must consolidate our findings on how behavioral activation works and when mediation occurs.

Reflexive Response of Neck Muscle to Sudden Perturbation after Prolonged Smartphone Use

Prolonged smartphone use induces passive stretch of neck tissues and muscle fatigue, affecting spinal stability and pain. It is necessary to evaluate the effect of smartphone use on the reflexive response to detect the changes in neck tissues and head stability. A laboratory experiment (n=10) was conducted to investigate the reflexive response of neck muscle to perturbation after 30 minutes of smartphone use. Neck extensor muscle activation and its activation timing to perturbation were investigated before and after smartphone use. Head angle and muscle activation level were collected during smartphone use. During smartphone use, muscle activation gradually increased. After smartphone use, neck muscles showed a higher activation level and significantly delayed onset to perturbation. Smartphone use changed the reflexive response of the neck muscle. Further study is needed to investigate the association between smartphone use and neuromuscular changes to the tissues of the cervical spine.

Oculo-retinal dynamics can explain the perception of minimal recognizable configurations

Natural vision is a dynamic and continuous process. Under natural conditions, visual object recognition typically involves continuous interactions between ocular motion and visual contrasts, resulting in dynamic retinal activations. In order to identify the dynamic variables that participate in this process and are relevant for image recognition, we used a set of images that are just above and below the human recognition threshold and whose recognition typically requires >2 s of viewing. We recorded eye movements of participants while attempting to recognize these images within trials lasting 3 s. We then assessed the activation dynamics of retinal ganglion cells resulting from ocular dynamics using a computational model. We found that while the saccadic rate was similar between recognized and unrecognized trials, the fixational ocular speed was significantly larger for unrecognized trials. Interestingly, however, retinal activation level was significantly lower during these unrecognized trials. We used retinal activation patterns and oculomotor parameters of each fixation to train a binary classifier, classifying recognized from unrecognized trials. Only retinal activation patterns could predict recognition, reaching 80% correct classifications on the fourth fixation (on average, ∼2.5 s from trial onset). We thus conclude that the information that is relevant for visual perception is embedded in the dynamic interactions between the oculomotor sequence and the image. Hence, our results suggest that ocular dynamics play an important role in recognition and that understanding the dynamics of retinal activation is crucial for understanding natural vision.

Algorithmically Deduced FREM2 Molecular Pathway Is a Potent Grade and Survival Biomarker of Human Gliomas

Gliomas are the most common malignant brain tumors with high mortality rates. Recently we showed that the FREM2 gene has a role in glioblastoma progression. Here we reconstructed the FREM2 molecular pathway using the human interactome model. We assessed the biomarker capacity of FREM2 expression and its pathway as the overall survival (OS) and progression-free survival (PFS) biomarkers. To this end, we used three literature and one experimental RNA sequencing datasets collectively covering 566 glioblastomas (GBM) and 1097 low-grade gliomas (LGG). The activation level of deduced FREM2 pathway showed strong biomarker characteristics and significantly outperformed the FREM2 expression level itself. For all relevant datasets, it could robustly discriminate GBM and LGG (p < 1.63 × 10−13, AUC > 0.74). High FREM2 pathway activation level was associated with poor OS in LGG (p < 0.001), and low PFS in LGG (p < 0.001) and GBM (p < 0.05). FREM2 pathway activation level was poor prognosis biomarker for OS (p < 0.05) and PFS (p < 0.05) in LGG with IDH mutation, for PFS in LGG with wild type IDH (p < 0.001) and mutant IDH with 1p/19q codeletion(p < 0.05), in GBM with unmethylated MGMT (p < 0.05), and in GBM with wild type IDH (p < 0.05). Thus, we conclude that the activation level of the FREM2 pathway is a potent new-generation diagnostic and prognostic biomarker for multiple molecular subtypes of GBM and LGG.

Influence of seat lumbar support adjustment on muscle fatigue under whole body vibration: An in vivo experimental study

BACKGROUND: In order to alleviate muscle fatigue and improve ride comfort, many published studies aimed to improve the seat environment or optimize seating posture. However, the effect of lumbar support on the lumbar muscle of seated subjects under whole body vibration is still unclear. OBJECTIVE: This study aimed to investigate the effect of lumbar support magnitude of the seat on lumbar muscle fatigue relief under whole body vibration. METHODS: Twenty healthy volunteers without low back pain participated in the experiment. By measuring surface electromyographic signals of erector spinae muscles under vibration or non-vibration for 30 minutes, the effect of different lumbar support conditions on muscle fatigue was analyzed. The magnitude of lumbar support d is assigned as d1= 0 mm, d2= 20 mm and d3= 40 mm for no support, small support and large support, respectively. RESULTS: The results showed that lumbar muscle activation levels vary under different support conditions. For the small support case (d2= 20 mm), the muscle activation level under vibration and no-vibration was the minimum, 42.3% and 77.7% of that under no support (d1= 0 mm). For all support conditions, the muscle activation level under vibration is higher than that under no-vibration. CONCLUSIONS: The results indicate that the small support yields the minimum muscle contraction (low muscle contraction intensity) under vibration, which is more helpful for relieving lumbar muscle fatigue than no support or large support cases. Therefore, an appropriate lumbar support of seats is necessary for alleviating lumbar muscle fatigue.