Optimum design of two-material bending plate compliant devices

PurposeThe purpose of this study is to explore the optimum design of bending plate compliant mechanisms subjected to pure mechanical excitations using topological-derivative-based topology optimization. The main objective is to design the reinforcement in a plate of base material.Design/methodology/approachThe optimum design is performed by means of a level-set representation method guided by topological derivatives. Kirchhoff and Reissner–Mindlin models are used to solve the linear bending plate problem. A qualitative comparison has been carried out between the optimal obtained topologies for each model.FindingsThe proposed methodology was able to design reinforcement in a plate of the base material. The obtained reinforcements notably improve the device’s behavior. The shape and topology of the reinforcements vary depending on the mechanical plate model considered. In fact, in the Reissner–Mindlin solutions, very thin flexo-torsional hinges connecting big zones of the reinforcement material are designed.Originality/valueUp to date, the synthesis of ortho-planar mechanisms by means of continuum topology optimization was only boarded within a multi-physics context. In this work, the optimal design of pure ortho-planar compliance actuators is addressed. The best performance is found by analyzing the results for two classical mechanical plate models.

Evaluation of the Level of Fit of Radial Fracture Fixation Plates Using Virtual and 3D-printed Models

Radial fractures often require surgical stabilization with fracture fixation plates. Incomplete morphological reconstruction was linked to poor outcome such as limited forearm rotation. Pre-contoured plates are often used, but large inter-subject morphological variations may result in poor fit. Therefore, the goal of this study was to develop a reliable virtual measure of plate-to-bone fit. In addition, the study evaluated the accuracy with which 3D printed bones reproduce the morphology of the physical radius. Virtual models and 3D-printed models of six cadaver radii were produced from bone scans. Level of fit of pre-contoured plates were measured in three ways: directly on pre-contoured physical plates fitted to cadaver bone; pre-contoured physical plates fitted to 3D printed bone; and virtual plate models fitted to virtual bone models. In addition, the study evaluated the accuracy with which 3D printed bone reproduces the physical bone morphology. The results indicate excellent agreement between the physical and virtual level of fit measures as well as excellent geometrical accuracy of the 3D-printed bones. These provide the necessary foundation for guiding the development of better fitted pre-contoured fracture fixation plates as well as for developing pre-surgically patient specific pre-contoured plates.

Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models

This study aims to evaluate the antinociceptive effect of the C. rhamnifolioides leaf essential oil (OEFC) and the β-cyclodextrin inclusion complex (COEFC) and investigate the pain signaling pathways involved in the antinociceptive response. The effects of the OEFC and COEFC on the central nervous system (CNS) were determined by open field and rota-rod assays, and the antinociceptive effect was evaluated via the acetic acid-induced abdominal contortions, formalin, and hot plate models. Swiss (Mus musculus) male mice (20–30 g) were used in both trials. The OEFC (200 mg/kg/v.o-orally) and COEFC (83.5 mg/kg/v.o.) did not present alterations in the CNS. The OEFC (25, 50, 100, and 200 mg/kg/vo.) and COEFC (8.35, 41.75, and 83.5 mg/kg/v.o.) demonstrated antinociceptive effects in the abdominal contortions, formalin, and hot plate tests. The OEFC (25 mg/kg/v.o.) and COEFC (8.35 mg/kg/v.o.) doses showed that the antinociceptive effect involves the activation of the opioid, cholinergic, and vanilloid systems, as well as the L-arginine/NO and α-2 adrenergic receptor pathways. The antinociceptive potential the OEFC and COEFC demonstrate possible alternatives for the therapy of pain. However, the COEFC presented more significant effects at lower doses than the isolated OEFC, where this action may be justified by the properties and advantages of the complexation.

Plate tectonics and Earth System Science

<p>Over the last 25 years the theory of plate tectonics and a growing set of geo-databases have been used to develop global plate models with increasing sophistication, enabled by open-source plate reconstruction software, particularly GPlates. Today’s editable open-access community models include networks of evolving plate boundaries and deforming regions, reflecting the fact that tectonic plates are not always rigid. The theory of plate tectonics was originally developed primarily based on magnetic anomaly and fracture zone data from the ocean basins. As a consequence there has been a focus on applying plate tectonics to modelling the Jurassic to present-day evolution of the Earth based on the record of preserved seafloor, or only modelling the motions of continents at earlier times. Modern plate models are addressing this shortcoming with recently developed technologies built upon the pyGPlates python library, utilising evolving plate boundary topologies to reconstruct entirely destroyed seafloor for the entire Phanerozoic. Uncertainties in these reconstructions are large and can represented with end-member scenarios. These models are paving the way for a multitude of applications aimed at better understanding Earth system evolution, connecting surface processes with the Earth’s mantle via plate tectonics. These models allow us to address questions such as: What are the causes of major perturbations in the interplay between tectonic plate motion and Earth’s deep interior? How do lithospheric deformation, mantle convection driven dynamic topography and climate change together drive regional changes in erosion and sedimentation? How are major perturbations of the plate-mantle system connected to environmental change, biological extinctions and species radiation?</p>

Investigating the plate kinematics of continental blocks and their role on the deformation experienced along the Iberia-Eurasia plate boundary using deformable plate tectonic models

<p>The kinematics of the Iberian plate during Mesozoic extension and subsequent Alpine compression and their implications on the partitioning of strain experienced across the Iberia-Europe plate boundary continue to be a subject of scientific interest, and debate. To date, the majority of plate tectonic models only consider the motion of rigid tectonic plates. In addition, the lack of consideration for the kinematics of intra-continental domains and intervening continental blocks in-between has led to numerous discrepancies between rigid plate kinematic models of Iberia, based mainly on tight-fit reconstruction of M-series magnetic anomalies, and their ability to reconcile geological and geophysical observations. To address these discrepancies, deformable plate tectonic models constrained by previous plate reconstructions, geological, and geophysical studies are built using the GPlates software to study the evolution of deformation experienced along the Iberia-Eurasia plate boundary from the Triassic to present day. These deformable plate models consider the kinematics of small intra-continental blocks such as the Landes High and Ebro Block situated between large tectonic plates, their interplay with pre-existing structural trends, and the collective impact of these phenomena on the deformation experienced during Mesozoic rifting and Alpine compressional re-activation along the Iberia-European plate boundary. Preliminary results suggest that the independent kinematics of the Landes High played a key role on the distribution of oblique extension between different rift arms and resultant deformation within the Bay of Biscay. Within the Pyrenean realm, deformation experienced prior to and during the Alpine Orogeny was more largely controlled by the interplay between the Ebro Block kinematics and rift segmentation induced by the orientation of inherited trends.</p>