Ultraviolet-C Irradiation, Heat, and Storage as Potential Methods of Inactivating SARS-CoV-2 and Bacterial Pathogens on Filtering Facepiece Respirators

The arrival of SARS-CoV-2 to Aotearoa/New Zealand in February 2020 triggered a massive response at multiple levels. Procurement and sustainability of medical supplies to hospitals and clinics during the then upcoming COVID-19 pandemic was one of the top priorities. Continuing access to new personal protective equipment (PPE) was not guaranteed; thus, disinfecting and reusing PPE was considered as a potential alternative. Here, we describe part of a local program intended to test and implement a system to disinfect PPE for potential reuse in New Zealand. We used filtering facepiece respirator (FFR) coupons inoculated with SARS-CoV-2 or clinically relevant multidrug-resistant pathogens (Acinetobacter baumannii Ab5075, methicillin-resistant Staphylococcus aureus USA300 LAC and cystic-fibrosis isolate Pseudomonas aeruginosa LESB58), to evaluate the potential use of ultraviolet-C germicidal irradiation (UV-C) or dry heat treatment to disinfect PPE. An applied UV-C dose of 1000 mJ/cm2 was sufficient to completely inactivate high doses of SARS-CoV-2; however, irregularities in the FFR coupons hindered the efficacy of UV-C to fully inactivate the virus, even at higher UV-C doses (2000 mJ/cm2). Conversely, incubating contaminated FFR coupons at 65 °C for 30 min or 70 °C for 15 min, was sufficient to block SARS-CoV-2 replication, even in the presence of mucin or a soil load (mimicking salivary or respiratory secretions, respectively). Dry heat (90 min at 75 °C to 80 °C) effectively killed 106 planktonic bacteria; however, even extending the incubation time up to two hours at 80 °C did not completely kill bacteria when grown in colony biofilms. Importantly, we also showed that FFR material can harbor replication-competent SARS-CoV-2 for up to 35 days at room temperature in the presence of a soil load. We are currently using these findings to optimize and establish a robust process for decontaminating, reusing, and reducing wastage of PPE in New Zealand.

Fertile Ground: Implementing the 2030 Agenda in U.S. Cities

The 2030 Agenda for Sustainable Development promotes sustainable global prosperity by encouraging the coordination of social, economic, and environmental policies and good governance reforms. Cities are expected to play an essential role in implementing the 2030 Agenda. Local programs are to be implemented by multi-actor governance systems (including government agencies, businesses, nonprofits, and philanthropic organizations) that operate across multiple policy domains and provide extensive opportunities for stakeholder participation. Local program finance may require a combination of public, private, and philanthropic resources. We analyze the prospects for local implementation of the 2030 Agenda in large U.S. cities by examining local capacity to plan and carry out cross-sectoral collaborative initiatives. We review sustainability planning in the cities that participated in the Sustainable Development Solutions Network planning demonstration. We analyze an inventory of urban revitalization initiatives to assess local capacity to carry out collaborations. We show that local capacity is associated with having an active local environmental agenda and making progress toward achieving sustainable development goals. However, local capacity appears to be concentrated in larger cities. Although the demands on local governance are daunting, our examination of local capacity to plan and execute cross-sectoral collaborative initiatives in large U.S. cities creates guarded optimism.

Exploring Factors Contributing to the Implementation of Ontario’s Healthy Kids Community Challenge: Surveys and Key Stakeholder Interviews with Program Providers

(1) Background: To explore factors contributing to the Healthy Kids Community Challenge (HKCC) program implementation; (2) Methods: Data were collected through a quantitative survey (n = 124) and in-depth telephone interviews (n = 16) with program providers. Interviews were recorded and transcribed for thematic analysis using NVivo; (3) Results: Provincial funding and in-kind support from community partners were key. Initiatives were feasible to implement, and key messages were well-received by communities. Specific practices and process were commonly discussed, and strong local program leadership was crucial to implementation; (4) Conclusions: Results have implications for planning and implementing future multi-component, community-based health promotion programs that include similar partnerships.

An Integrated MERLA (Monitoring, Evaluation, Research, Learning, and Adapting) Framework for Evidence-Based Program Improvement

Monitoring, evaluation, and research activities generate important data, but they often fail to change policies or programs. In addition, local program staff and partners often feel disconnected from these activities, which undermines their ownership of data and results. To bridge the gaps between monitoring, evaluation, and research and to give them a common purpose through locally owned, actionable learning, we developed an integrated Monitoring, Evaluation, Research, Learning, and Adapting (MERLA) framework. Implemented and refined in over 20 countries, the framework integrates data-gathering methodologies with collaborative techniques for translating evidence into knowledge that influences program practice and government policy. In this publication, we describe the MERLA framework and present two case studies demonstrating how its application enables learning and adaptation led by in-country teams.

What Can You Do With a Bachelor's in Public Health? A Case Study of Graduate Outcomes From the University of Hawai‘i

Since the development of a Bachelor of Arts in public health, a common question among prospective students, faculty, and community members has been asked: “What will students do after graduation?” While national data on graduates are abundant, community inquiries sought more detailed profiles of local graduates. To address this need, data on 224 graduates of the Bachelors of Arts in Public Health (BAPH) degree at the University of Hawai‘i at Mānoa were collected through alumni outreach efforts and professional online profile searches. Data were compiled into a summary presentation and program “resume”. Findings indicated roughly 30% of BAPH graduates pursued graduate-level education and 43% were employed within a year of graduation. Employment in local NGOs and healthcare organizations was common, while bureaucratic challenges limited hiring at public agencies. A review of job titles suggested graduates were employed in program coordination or support staffing. Local program profiles, such as this one, complement national employment data. Moreover, these efforts may foster interest among prospective students and support from faculty, administrators, and employers.

Wired and Hired: Employment Effects of Subsidized Broadband Internet for Low-Income Americans

I present evidence on the relationship between broadband pricing and labor market outcomes for low-income individuals. Specifically, I estimate the effects of a Comcast service providing discounted broadband to qualifying low-income families. I use a triple differences strategy exploiting geographic variation in Comcast coverage, individual variation in eligibility, and temporal variation pre- and postlaunch. Local program availability increased employment rates and earnings of eligible individuals, driven by greater labor force participation and decreased probability of unemployment. Internet use increased substantially where the program was available. (JEL I32, J22, J31, L82, L86)

Implementation of Private Television Policy Based on Broadcasting Regulation: Case Study of Malang City Local Program

It has been 18 years since the enactment of Law of The Republic of Indonesia Number 32 of 2002 on Broadcasting in Indonesia. During that time, Sistem Siaran Jaringan or commonly known as SSJ became the national broadcasting system. One of the elements in SSJ that differentiates it from the previous broadcasting system is the obligation for private broadcasters in Indonesia to broadcast local programs as much as 10% of their total broadcast hours. The hopes of Law of The Republic of Indonesia Number 32 of 2002 on Broadcasting, diversity of content and diversity of ownership, are often echoed in research related to broadcasting activities as a "revolution" from the previous broadcasting law which had the impression of being centralized from Jakarta. How are things now? Has this objective been implemented properly by private broadcaster in its broadcasting activities in Malang City?.

The Effectiveness of a Neighbor-to-Neighbor Get-Out-the-Vote Program: Evidence from the 2017 Virginia State Elections

We analyze the results of a neighbor-to-neighbor, grassroots get-out-the-vote (GOTV) drive in Virginia, in which unpaid volunteers were encouraged to contact at least three nearby registered voters who were likely co-partisans yet relatively unlikely to vote in the 2017 state election. To measure the campaign’s effectiveness, we used a pairwise randomization design whereby each volunteer was assigned to one randomly selected member of the most geographically proximate pair of voters. Because some volunteers unexpectedly signed up to participate outside their home districts, we analyze the volunteers who adhered to the original hyper-local program design separately from those who did not. We find that the volunteers in the original program design drove a statistically significant 2.3% increase in turnout, which was concentrated in the first voter pair assigned to each volunteer. We discuss implications for the study and design of future GOTV efforts.

The Living-Related Kidney Transplant Program in Brunei Darussalam: Lessons Learnt from a Nascent National Program in a Small, Muslim, and Asian Country

Brunei Darussalam commenced its living-related renal transplant program in 2013, with subsequent attainment of independent local capacity and proficiency in 2019. The preliminary outcome from the program has already begun to shape the national nephrology landscape with a 36% increment in transplant rate and mitigation of commercialized transplantations. The blueprint for the program was first laid out in 2010 and thereupon executed in four phases. The first phase involved the gathering of evidence to support the establishment of the national program, through researches investigating feasibility, public opinion, quality of life, graft survival, and cost-effectiveness. The second phase focused on laying the foundation of the program through grooming of local expertise, implementation of legal-ethical frameworks, religious legitimization, and propagation of awareness. The third phase worked on facilitating experiential exposure and strengthening local infrastructure through the upgrading of facilities and the introduction of subsidiary services. The fourth phase was implemented in Brunei in 2013 when foreign personnel worked together with the local team to perform the transplants. Between 2013 and 2019, ten kidney transplants were performed, with two being done in 2018 and three in 2019. We hope to inspire other similar countries to develop their own self-sustainable and independent local program.

Modelling the factors affecting the probability for local rabies elimination by strategic control

Dog rabies has been recognized from ancient times and remains widespread across the developing world with an estimated 59,000 people dying annually from the disease. In 2011 a tri-partite alliance consisting of the OIE, the WHO and the FAO committed to globally eliminating dog-mediated human rabies by 2030. Regardless of global support, the responsibility remains with local program managers to implement successful elimination programs. It is well known that vaccination programs have a high probability of successful elimination if they achieve a population-coverage of 70%. It is often quoted that reducing population turnover (typically through sterilizations) raises the probability for local elimination by maintaining herd immunity for longer. Besides this, other factors that affect rabies elimination are rarely mentioned. This paper investigates the probability for local elimination as it relates to immunity, fecundity, dog population size, infectivity (bite rates), in-migration of immune-naïve dogs, and the initial incidence. To achieve this, an individual-based, stochastic, transmission model was manipulated to create a dataset covering combinations of factors that may affect elimination. The results thereof were analysed using a logistic regression model with elimination as the dependent variable. Our results suggest that smaller dog populations, lower infectivity and lower incidence (such as when epidemics start with single introductions) strongly increased the probability for elimination at wide ranges of vaccination levels. Lower fecundity and lower in-migration had weak effects. We discuss the importance of these findings in terms of their impact and their practical application in the design of dog-mediated rabies control programs.