Physicochemical, microbiological and sensorial characteristics of flour and prepared cookies from the reject cashew (Anacardium occidentale L.) neglected

Nowadays, one of the main objectives of biotechnological development of new products is linked to processes and methods improvement. In this sense, the aim of this work is to promote the sustainable development of the residue obtained from the cashew´s organic reject material aiming at to produce a target flour to be applied as a functional food. In fact, the nutritional composition of the cashew flour showed an important food profile related to fibers and carbohydrates. In relation to the prepared food as a simple possibility, cookies were produced, and its sensorial characteristics were carried out in individual booths, with 100 non trained evaluators. The results showed that the cookies demonstrated a satisfactory acceptance profile in several analyzed attributes. Concerning to the microbiological analysis, nonsignificant presence of microorganisms was detected. So, the processed cashew flour showed to be nutritionally acceptable and together with a good sensorial acceptance, can be considered as a suitable biomass to produce a large amount of bakery products.

Injectable Enzymatically Hardened Calcium Phosphate Biocement

(1) Background: The preparation and characterization of novel fully injectable enzymatically hardened tetracalcium phosphate/monetite cements (CXI cements) using phytic acid/phytase (PHYT/F3P) hardening liquid with a small addition of polyacrylic acid/carboxymethyl cellulose anionic polyelectrolyte (PAA/CMC) and enhanced bioactivity. (2) Methods: Composite cements were prepared by mixing of calcium phosphate powder mixture with hardening liquid containing anionic polyelectrolyte. Phase and microstructural analysis, compressive strength, release of ions and in vitro testing were used for the evaluation of cement properties. (3) Results: The simple possibility to control the setting time of self-setting CXI cements was shown (7–28 min) by the change in P/L ratio or PHYT/F3P reaction time. The wet compressive strength of cements (up to 15 MPa) was close to cancellous bone. The increase in PAA content to 1 wt% caused refinement and change in the morphology of hydroxyapatite particles. Cement pastes had a high resistance to wash-out in a short time after cement mixing. The noncytotoxic character of CX cement extracts was verified. Moreover, PHYT supported the formation of Ca deposits, and the additional synergistic effect of PAA and CMC on enhanced ALP activity was found, along with the strong up-regulation of osteogenic gene expressions for osteopontin, osteocalcin and IGF1 growth factor evaluated by the RT-qPCR analysis in osteogenic αMEM 50% CXI extracts. (4) Conclusions: The fully injectable composite calcium phosphate bicements with anionic polyelectrolyte addition showed good mechanical and physico-chemical properties and enhanced osteogenic bioactivity which is a promising assumption for their application in bone defect regeneration.

Human Infection Challenge Studies: a Test for the Social Value Criterion of Research Ethics

Human infection challenge studies involving the intentional infection of research participants with a disease-causing agent have recently been suggested as a means to speed up the search for a vaccine for the ongoing coronavirus disease 2019 (COVID-19) outbreak. Calls for challenge studies, however, rely on the expected social value of these studies. This value represents more than the simple possibility that a successful study will lead to the rapid development and dissemination of vaccines but also some expectation that this will actually occur.

Conquering Megalomania and Despair: a Niebuhrian Response to the Politico-Economic Impasse

The works of Reinhold Niebuhr contain invaluable examples of how Christian resources can be fruitfully exploited to address urgent economic and political issues. The ideas of sin and continuous redemption, which arguably belong to the core of the Christian faith, are creatively translated by Niebuhr, so that they can be included in public debates and interdisciplinary dialogues. In this article, his conception of sin as the perversion of the will-to-live into the will-to-power is endorsed. Its counterforce, it is argued, is human love infused with divine love. Love is, therefore, not a simple possibility, which can be applied to our economic and political problems. Instead, it is the impossible possibility, the ultimate and critical perspective from which prevailing forms of justice and philanthropy are judged. Through the public theology of Niebuhr, the ideal of love becomes a universally valid alternative to the rationalist and naturalist approaches to human morality.

Intellectual Thermoconductometric Unit Based on Aerosol Printed Ceramic MEMS Sensor for the Measurement of Natural Gas Composition

The online control of natural gas quality is important for customers, because for them the important value is calorific value of consumed gas, but not its volume. The application of thermoconductometric sensor gives simple possibility to fabricate imbedded intellectual plug-and-play device for this control. The ceramic MEMS sensor based on a combination of this ceramic LTCC membrane and aerosol jet printed platinum microheater was used as a sensing element of this unit. The electronic unit controlling the sensor was designed to stabilize the temperature of the microheater and to measure power necessary to maintain this temperature at different concentrations of N2and CO2 in natural gas. The application of this unit enables the measurement of admixtures of nitrogen and CO2 with detection limit of about 1 vol. % sufficient for the application in gas meter instruments.

Wafer Extension for Cost-Effective Front to Back Side Alignment

This work presents a cost-effective and simple possibility to outperform the potential of a standard single side mask aligner. The limited functionality is extended to the capability of back side alignment with minimal effort without additional knowledge and integration of new process technologies. The whole presented process flow performs without the necessity of additional equipment as infrared back side wafer alignment kits or additional etching processes or clamps and brackets. The result is a front to back side alignment process with satisfactory deviation.

REPLY TO LYNN

Do males and females differ in general intelligence? Lynn (1994, 1998) and I (Mackintosh, 1996) agree that the answer to this question must depend on the answer to two prior questions: what is the definition of general intelligence, and what tests best measure it? Our disagreement arises partly from different answers to these prior questions, but also from differences in our reading of some not wholly consistent evidence. What answers might one give to these prior questions? They are not independent, for a possible (severely operational) definition of general intelligence is that it is a person's score on one particular IQ test battery. Let us start with that simple possibility.

Identification of the sequences in HMG-CoA reductase required for karmellae assembly.

In all eukaryotic cells that have been examined, specific membrane arrays are induced in response to increased levels of the ER membrane protein, HMG-CoA reductase. Analysis of these inducible membranes has the potential to reveal basic insights into general membrane assembly. Yeast express two HMG-CoA reductase isozymes, and each isozyme induces a morphologically distinct proliferation of the endoplasmic reticulum. The isozyme encoded by HMG1 induces karmellae, which are long stacks of membranes that partially enclose the nucleus. In contrast, the isozyme encoded by HMG2 induces short stacks of membrane that may be associated with the nucleus, but are frequently present at the cell periphery. To understand the molecular nature of the different cellular responses to Hmg1p and Hmg2p, we mapped the region of Hmg1p that is needed for karmellae assembly. For this analysis, a series of exchange alleles was examined in which a portion of the Hmg2p membrane domain was replaced with the corresponding Hmg1p sequences. Results of this analysis indicated that the ER lumenal loop between predicted transmembrane domains 6 and 7 was both necessary and sufficient for karmellae assembly, when present in the context of an HMG-CoA reductase membrane domain. Immunoblotting experiments ruled out the simple possibility that differences in the amounts of the various chimeric HMG-CoA reductase proteins was responsible for the altered cellular responses. Our results are consistent with the hypothesis that each yeast isozyme induces or organizes a qualitatively different organization of ER membrane.

SPECIFICITY OF INSERTION BY THE TRANSLOCATABLE TETRACYCLINE-RESISTANCE ELEMENT Tn10

ABSTRACT Genetic analysis of 131 independent transpositions of the tetracycline-resistance element TnlO from a single site in phage P22 into the histidine operon of Salmonella typhimurium reveals that Tn1O insertions are not randomly distributed along this chromosomal target. The insertions occur in 22 different "clusters"; insertions within each cluster are very tightly linked in recombination tests. TnlO insertions are not evenly distributed among the identified clusters. The existence of these clusters suggests that this chromosomal target contains particular genetic signals that guide TnlO to particular preferred positions for insertion. Insertions within each cluster occur in both orientations with roughly equal frequency.——The relationship among different insertions within each cluster has been examined. The resolution of genetic mapping places an upper limit of about 50 basepairs on the distance between different insertions within a cluster. Different insertions within a cluster usually have the same reversion frequency; however, heterogeneity in reversion frequency has been detected in at least two clusters. For most clusters, the available data are consistent with the simple possibility that all insertions within a cluster are at identical positions; however, the data do not exclude other possibilities.