Reaction of radiometric parameters to atmospheric pollution: Part I - Variation over time

The drive for indust rial development h... ... 100 to large scale urbanisation and result,.-. d in theinjec tion of good amount of suspended particle.. and gaseous substances into the atmosphere. The m..er-abuscof the capac ity .of the atmosphere to sustain the equilibrium is bound to disturb the heal budget of the earthatmospheresystem. Radiometric parameters of the atmosphere give an early indication of the trends in the longtermclimatic changes. Whi le the global rad iant exposure is no t likely to show perceptible changes due to theincreased scauering by the pollutants, I ~ ~ diffuse radiant el(p(ls~re and the direct so.l3! irradianc~ respond qu icklyto the changes In the atmospheric conditions. Various controlling factors like humidity. soi l moist ure and cloud"have d ifferent effects on the terres trial radiant energy and the changes in thi s energy OI..'Cur slowly and ta ke longtime to affect the climate at a place. But the general trend is indicated by the increased diffuse component in thedi rect sola r rrmdiances and in the net outgoing terrestrial radia nt energy. The responses arc clearly indicative.part icularly ,II Punc......here the industrial activiti es grew at a phenomenal rate during the past fifteen years.

Henry Moore’s Narayana and Bhataryan: theatre of sacrifice

Henry Moore’s unpublished play Narayana and Bhataryan (c. 1919) was first performed in 1920 at Castleford Secondary School. Moore wrote, performed in and designed the programme for this play. Despite timely theatrical returns to Moore’s only surviving literary creation, this play has not yet been the subject of in-depth critical study. Using archival research, this article engages with the play’s early indication of Moore’s sculptural tendencies. It traces the play’s parallels with another play produced in the early twentieth century: Rabindranath Tagore’s Sacrifice. Doing so highlights the cross-cultural echoes that exist in Narayana and Bhataryan, its relationship to early twentieth-century global modernist movements, the thematic presence of posture, architecture, ritual and trauma, and the emergence of Moore’s lifelong concerns with the mother and child and the human body. This article places Moore’s play in critical relationship to his sculpture and introduces his lone contribution to the fabric of modern drama as having cross-cultural relevance in the 1980s when an exhibition of his work toured India.

Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?

Bisphenols and phthalates affect androgen receptor-mediated signaling that directly regulates Kallikrein-Related serine Peptidase 3 (KLK3) secretion, indicating that environmental factors may play a role in KLK3 secretion. With the aim of obtaining preliminary data on whether KLK3 could serve as an early marker of environmental pollution effects, in 61 and 58 healthy women living in a high environmental impact (HEI) and low environmental impact (LEI) area, respectively, serum KLK3 levels at different phases of menstrual cycle were measured. KLK3 values resulted in always being higher in the HEI group with respect to the LEI group. These differences were particularly relevant in the ovulatory phase (cycle day 12°–13°) of the menstrual cycle. The differences in KLK3 values during the three phases of the menstrual cycle were significant in the LEI group differently from the HEI group. In addition, higher progesterone levels were observed in the LEI group with respect to the HEI group in the luteal phase, indicating an opposite trend of KLK3 and progesterone in this phase of the menstrual cycle. Although changes in KLK3 could also depend on other factors, these preliminary data could be an early indication of an expanding study of the role of biomarkers in assessing early environmental effects for female reproductive health.

Harmonization status of procalcitonin measurements: what do comparison studies and EQA schemes tell us?

Sepsis represents a global health priority because of its high mortality and morbidity. The key to improving prognosis remains an early diagnosis to initiate appropriate antibiotic treatment. Procalcitonin (PCT) is a recognized biomarker for the early indication of bacterial infections and a valuable tool to guide and individualize antibiotic treatment. To meet the increasing demand for PCT testing, numerous PCT immunoassays have been developed and commercialized, but results have been questioned. Many comparison studies have been carried out to evaluate analytical performance and comparability of results provided by the different commercially available immunoassays for PCT, but results are conflicting. External Quality Assessment Schemes (EQAS) for PCT constitute another way to evaluate results comparability. However, when making this comparison, it must be taken into account that the variety of EQA materials consist of different matrices, the commutability of which has not yet been investigated. The present study gathers results from all published comparison studies and results from 137 EQAS surveys to describe the current state-of-the-art harmonization of PCT results. Comparison studies globally highlight a significant variability of measurement results that nonetheless seem to have a moderate impact on medical decision-making. For their part, EQAS for PCT provides highly discrepant estimates of the interlaboratory CV. Due to differences in commutability of the EQA materials, the results from different peer groups could not be compared. To improve the informative value of the EQA data, the existing limitations such as non-harmonized conditions and suboptimal and/or unknown commutability of the EQA materials have to be overcome. The study highlights the need for commutable reference materials that could be used to properly evaluate result comparability and possibly standardize calibration, if necessary. Such an initiative would further improve the safe use of PCT in clinical routine.

A Review of Static Code Analysis Methods for Detecting Security Flaws

Static checkers are commonly used by programmers; they verify our programmers for flaws without executing them, a process known as static code analysis. It works with a program that has an early indication of correctness in this way, attempting to avoid well-known traps and problems before comparing it to its specifications. Software security is becoming increasingly crucial in order for programmers to be universally accepted for a wide range of transactions. During the development process, automated code analyzers can be used to detect security flaws. The purpose of this paper is to provide an overview of static code analysis and how it may be used to uncover security flaws. This document summarizes and presents the most recent discoveries and publications. The gains flow, and methods of static code analyzers are discussed in this study. It can be viewed as a stepping stone toward more research in this area. In Java, there are two types of static code checkers: those that work directly on the source code and those that work on the produced bytecode. Although each code checker is unique, they all share some common characteristics. They read the software and build a model of it, an abstract representation that they may use to match the error patterns they notice. They also perform a data-flow analysis, attempting to deduce the probable values of variables at various stages in the program. Vulnerability testing, an increasingly significant field for code checkers, necessitates data-flow analysis.

Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP

Safe and effective coronavirus disease–19 (COVID-19) vaccines are urgently needed to control the ongoing pandemic. While single-dose vaccine regimens would provide multiple advantages, two doses may improve the magnitude and durability of immunity and protective efficacy. We assessed one- and two-dose regimens of the Ad26.COV2.S vaccine candidate in adult and aged nonhuman primates (NHPs). A two-dose Ad26.COV2.S regimen induced higher peak binding and neutralizing antibody responses compared with a single dose. In one-dose regimens, neutralizing antibody responses were stable for at least 14 wk, providing an early indication of durability. Ad26.COV2.S induced humoral immunity and T helper cell (Th cell) 1–skewed cellular responses in aged NHPs that were comparable to those in adult animals. Aged Ad26.COV2.S-vaccinated animals challenged 3 mo after dose 1 with a SARS-CoV-2 spike G614 variant showed near complete lower and substantial upper respiratory tract protection for both regimens. Neutralization of variants of concern by NHP sera was reduced for B.1.351 lineages while maintained for the B.1.1.7 lineage independent of Ad26.COV2.S vaccine regimen.

Covid-19 in familial cluster: ultrashort incubation period could be an early indication of Brazilian Variant of SARS-Cov-2 virus?

Objective: To describe the occurrence of COVID-19 with an ultra-short incubation period in a familial cluster. Experience report: Description of a series of eighteen cases of COVID-19 from the same familial cluster, with possible contamination at a social dinner. The time elapsed between the family reunion and the onset of each guest's symptoms was described. The cases that have been tested and their results are presented. Experience report: Nineteen people from a family group were followed for twelve days. The average incubation period was 37.16 hours. The incubation period was 24 hours in 11.11% of the cases, 36 hours in 66.67% and 48 hours in 22.22% of the individuals in the cluster. In just over five percent of patients, the estimated incubation period was 96 hours. The most frequent initial symptom was cough (38.8%). Final considerations: An ultrashort incubation period for SARS-CoV-2 can be an important alert for a new COVID-19 standard. However, our study is limited by the scarce number of individuals and the lack of tests before the meeting.

Analysis Application of Altman (Z-Score) Method and Springate (S-Score) Method to Assess Financial Distress Potential at PT Anugerah

The emergence of potential financial distress is an early indication of a decline in the company's financial condition. The purpose of this research is to determine the potential of financial distress at PT Anugerah, so that it will help management anticipate the potential financial distress in the company. In this research, the assessment of financial distress potential uses the Altman (Z-score) method and Springate (S-score) method. The type of data in this research is quantitative and qualitative sourced from secondary data and obtained through interviews, documentation, and observation. The data analysis technique used is a qualitative/descriptive analysis technique. The results of research study are the financial distress potential of PT Anugerah by using the Altman (Z-score) method in 2016-2019 shows PT Anugerah is in a non-financial distress condition, because the score is in the condition of Z’’> 2.6. Furthermore, PT Anugerah financial distress potential using the Springate (S-score) method in 2016-2019 shows that PT Anugerah is in a non-financial distress condition, because the score is at S > 0.862.

Author Correction: Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts

An amendment to this paper has been published and can be accessed via a link at the top of the paper.