fenclozic acid
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scholarly journals The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

2018 ◽  
Vol 92 (9) ◽  
pp. 2819-2828 ◽  
Author(s):  
Anja Ekdahl ◽  
Lars Weidolf ◽  
Matthew Baginski ◽  
Yoshio Morikawa ◽  
Richard A. Thompson ◽  
...  
Keyword(s):  
Chimeric Mice ◽  
Metabolic Fate ◽  
Fenclozic Acid

scholarly journals Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

2017 ◽  
Vol 6 (1) ◽  
pp. 81-88 ◽  
Author(s):  
James A. Akingbasote ◽  
Alison J. Foster ◽  
Huw B. Jones ◽  
Rhiannon David ◽  
Nigel J. Gooderham ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Toxicity ◽  
Cytochrome P450 Reductase ◽  
Hepatic Drug ◽  
P450 Reductase ◽  
Liver Histopathology ◽  
Drug Biotransformation ◽  
Fenclozic Acid ◽  
Hepatic Cytochrome

HRN™ mice are valuable for P450-related hepatic drug biotransformation assessment, but not drug toxicity due to underlying liver histopathology.

scholarly journals Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice

2016 ◽  
Vol 91 (7) ◽  
pp. 2643-2653 ◽  
Author(s):  
Kathryn Pickup ◽  
Scott Martin ◽  
Elizabeth A. Partridge ◽  
Huw B. Jones ◽  
Jonathan Wills ◽  
...  
Keyword(s):  
Oral Administration ◽  
Metabolic Fate ◽  
Fenclozic Acid

Identification of the Reactive Metabolites of Fenclozic Acid in Bile Duct Cannulated Rats

2014 ◽  
Vol 86 (22) ◽  
pp. 11281-11289 ◽  
Author(s):  
Scott Martin ◽  
Eva M. Lenz ◽  
Warren Keene ◽  
Malcolm R. Clench
Keyword(s):  
Bile Duct ◽  
Reactive Metabolites ◽  
Fenclozic Acid

The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse

Xenobiotica ◽  
2013 ◽  
Vol 44 (2) ◽  
pp. 164-173 ◽  
Author(s):  
Kathryn Pickup ◽  
Jonathan Wills ◽  
Alison Rodrigues ◽  
Huw B. Jones ◽  
Chris Page ◽  
...  
Keyword(s):  
Metabolic Fate ◽  
Fenclozic Acid

In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid

2013 ◽  
Vol 87 (8) ◽  
pp. 1569-1579 ◽  
Author(s):  
Alison V. M. Rodrigues ◽  
Helen E. Rollison ◽  
Scott Martin ◽  
Sunil Sarda ◽  
Timothy Schulz-Utermoehl ◽  
...  
Keyword(s):  
Mechanisms Of Toxicity ◽  
Fenclozic Acid ◽  
Hepatotoxic Drug

The fate of fenclozic acid in the gut and its effect on some aspects of gut metabolism

Xenobiotica ◽  
1983 ◽  
Vol 13 (8) ◽  
pp. 483-496 ◽  
Author(s):  
C. G. Curtis ◽  
G. M. Powell ◽  
A. Bradbury ◽  
C. Rhodes
Keyword(s):  
Fenclozic Acid ◽  
Gut Metabolism

The effects of fenclozic acid on fertility of male rats

Contraception ◽  
1979 ◽  
Vol 19 (2) ◽  
pp. 129-134 ◽  
Author(s):  
W.D. Ratnasooriya ◽  
R.M. Wadsworth
Keyword(s):  
Male Rats ◽  
Fenclozic Acid
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